INT72006

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.26
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 13 96.28 Very High Very High Very High
Glutamate 14 93.56 High High
adenocard 93 92.08 High High
antagonist 18 89.68 High High
Pyramidal cell 7 79.76 Quite High
long-term potentiation 2 76.56 Quite High
agonist 33 75.40 Quite High
dopamine receptor 3 75.00 Quite High
Hippocampus 14 70.20 Quite High
Dynorphin 2 67.20 Quite High
Disease Link Frequency Relevance Heat
Disease 7 99.96 Very High Very High Very High
Drug Induced Neurotoxicity 2 88.88 High High
Targeted Disruption 1 71.80 Quite High
Hypoxia 8 5.00 Very Low Very Low Very Low
Neurological Disease 5 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the unilateral 6-hydroxydopamine-lesioned rat model of Parkinson's disease, blockade of A2A receptors facilitates L-dopa-induced turning behavior by antagonism of A2A transmission, which is increased after dopamine depletion.
Positive_regulation (facilitates) of Negative_regulation (blockade) of A2A associated with dopamine and disease
1) Confidence 0.40 Published 2003 Journal Neurology Section Abstract Doc Link 14663008 Disease Relevance 0.10 Pain Relevance 0.37
In this study, the functionality of A1Rs was not affected by NMDA preconditioning, but this treatment promoted A2AR desensitization in concert with A1R activation [83].
Positive_regulation (promoted) of Negative_regulation (desensitization) of A2AR
2) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.16 Pain Relevance 0.54
The reduction in these Galpha proteins also appears to mediate the loss of function of alpha2AR and perhaps of other G protein-coupled receptors.
Spec (appears) Positive_regulation (mediate) of Negative_regulation (loss) of alpha2AR
3) Confidence 0.03 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.04

General Comments

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