INT72008

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Context Info
Confidence 0.38
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.42
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

GTPase activity (Gnai2) cytoplasm (Gnai2) signal transducer activity (Gnai2)
cell proliferation (Gnai2) cytosol (Gnai2) nucleus (Gnai2)
Anatomy Link Frequency
artery 1
tail 1
AtT20 1
Gnai2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 97.00 Very High Very High Very High
Catecholamine 2 95.44 Very High Very High Very High
opioid receptor 3 94.88 High High
agonist 11 94.36 High High
potassium channel 3 93.20 High High
withdrawal 2 89.88 High High
MU agonist 4 88.24 High High
addiction 1 87.00 High High
Clonidine 2 77.84 Quite High
Serotonin 4 76.56 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 4 99.36 Very High Very High Very High
Glioma 1 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analyses of G protein alpha and beta subunits demonstrated that Galphaq and Galphai protein levels were decreased in PE-exposed tail artery membranes.
Gene_expression (levels) of Galphai protein in tail
1) Confidence 0.38 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.07
Heterologous desensitization of the rat tail artery contraction and inositol phosphate accumulation after in vitro exposure to phenylephrine is mediated by decreased levels of Galphaq and Galphai.
Gene_expression (levels) of Galphai in artery
2) Confidence 0.34 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.33
Pertussis toxin-insensitive Galphai1 and Galphai2 subunits tethered with mu-receptor were stably transfected into AtT20 cells to (i) determine coupling of different alpha-subunits on opioid efficacy, and (ii) determine coupling to downstream effectors, for example, calcium and potassium channels.
Gene_expression (transfected) of Galphai2 in AtT20 associated with bordatella infection, potassium channel and opioid
3) Confidence 0.28 Published 2008 Journal Neuroreport Section Abstract Doc Link 18955903 Disease Relevance 0.25 Pain Relevance 0.37
Inhibitory Galpha protein action is modulated by regulator of G protein signaling (RGS) proteins that act as GTPase activating proteins and reduce the lifetime of Galpha-GTP.
Gene_expression (reduce) of Galpha-GTP
4) Confidence 0.04 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15014136 Disease Relevance 0.17 Pain Relevance 0.72

General Comments

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