INT72011

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2008
Negated 2
Speculated 3
Reported most in Abstract
Documents 42
Total Number 45
Disease Relevance 2.72
Pain Relevance 39.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg)
Anatomy Link Frequency
brain 24
nucleus accumbens 6
parabrachial nucleus 4
superior colliculus 3
dentate gyrus 2
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 16 100.00 Very High Very High Very High
Neurotransmitter 3 100.00 Very High Very High Very High
gABA 1 100.00 Very High Very High Very High
Buprenorphine 101 99.98 Very High Very High Very High
Opioid 51 99.98 Very High Very High Very High
adenocard 43 99.98 Very High Very High Very High
Potency 6 99.98 Very High Very High Very High
Kappa opioid receptor 4 99.98 Very High Very High Very High
agonist 170 99.92 Very High Very High Very High
narcan 57 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 6 95.56 Very High Very High Very High
Glioma 6 94.80 High High
Bordatella Infection 7 93.36 High High
Tics 3 84.04 Quite High
Neuropathic Pain 1 83.36 Quite High
Opiate Addiction 20 81.72 Quite High
INFLAMMATION 4 76.96 Quite High
Nociception 1 64.12 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Buprenorphine and/or methadone gestational treatment attenuated DAMGO-induced GTP gamma S binding in some dam and male P2 mesolimbic regions.
Positive_regulation (induced) of GTP gamma S Binding (binding) of associated with methadone and buprenorphine
1) Confidence 0.50 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.15 Pain Relevance 1.60
Methadone diminished DAMGO-induced GTP gamma S binding in almost all monitored brain regions of the dam but had few effects on their N/OFQ-induced GTP gamma S binding.
Positive_regulation (induced) of GTP gamma S Binding (binding) of in brain associated with methadone
2) Confidence 0.50 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.14 Pain Relevance 1.69
Methadone diminished DAMGO-induced GTP gamma S binding in almost all monitored brain regions of the dam but had few effects on their N/OFQ-induced GTP gamma S binding.
Positive_regulation (induced) of GTP gamma S Binding (binding) of in brain associated with methadone
3) Confidence 0.50 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.13 Pain Relevance 1.73
Naloxone used in combination with buprenorphine blocked the inhibition by buprenorphine alone on DAMGO-induced GTP gamma S binding.
Positive_regulation (induced) of GTP gamma S Binding (binding) of associated with narcan and buprenorphine
4) Confidence 0.50 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.12 Pain Relevance 1.76
Chronic administration of amitriptyline resulted in a marked increase in 5-HT1A receptor-stimulated [35S]GTPgammaS binding in the hippocampus which was accompanied by an increase in 5-HT1A receptor number. 5-HT1A receptor-stimulated [35S]GTPgammaS binding in the hippocampus was also increased by chronic treatment with the highest dose of venlafaxine; 5-HT1A receptor number, however, was not significantly altered.
Positive_regulation (increase) of GTPgammaS Binding (binding) of in hippocampus associated with hippocampus and endep
5) Confidence 0.46 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16035959 Disease Relevance 0 Pain Relevance 0.55
GTPgammaS saturation analysis showed that chronic heroin treatment decreased the Bmax, and increased the K(D), of DAMGO-stimulated [35S]GTPgammaS binding.
Positive_regulation (increased) of GTPgammaS Binding (binding) of
6) Confidence 0.40 Published 2005 Journal Life Sci. Section Abstract Doc Link 15890372 Disease Relevance 0 Pain Relevance 0.63
Drug- and gender-based changes in DAMGO- and N/OFQ-induced GTP gamma S binding were discovered in mesolimbic regions of dam, P2, and P7 brains.
Positive_regulation (induced) of GTP gamma S Binding (binding) of in brains
7) Confidence 0.33 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.16 Pain Relevance 1.56
Brain region-dependent gender differences in DAMGO-induced GTP gamma S binding were seen in P2 pups, and males showed greater sensitivity to buprenorphine and methadone than females.
Positive_regulation (induced) of GTP gamma S Binding (binding) of in Brain associated with methadone and buprenorphine
8) Confidence 0.33 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.05 Pain Relevance 1.68
In contrast to its inhibitory effects on DAMGO-induced GTP gamma S binding, buprenorphine stimulated N/OFQ-induced GTP gamma S binding in male P2 nucleus accumbens and lateral septum.
Positive_regulation (induced) of GTP gamma S Binding (binding) of in nucleus accumbens associated with nucleus accumbens and buprenorphine
9) Confidence 0.33 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.11 Pain Relevance 1.79
In contrast to its inhibitory effects on DAMGO-induced GTP gamma S binding, buprenorphine stimulated N/OFQ-induced GTP gamma S binding in male P2 nucleus accumbens and lateral septum.
Positive_regulation (stimulated) of GTP gamma S Binding (binding) of in nucleus accumbens associated with nucleus accumbens and buprenorphine
10) Confidence 0.33 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.11 Pain Relevance 1.80
DAMGO stimulation of [35S]GTPgammaS binding in nuclei regulating REM sleep suggests that opioid-induced REM sleep inhibition involves activation of G proteins.
Positive_regulation (stimulation) of GTPgammaS Binding (binding) of associated with opioid
11) Confidence 0.31 Published 1998 Journal Neuroreport Section Abstract Doc Link 9804309 Disease Relevance 0 Pain Relevance 0.54
Moreover, depending of the area analysed, the basal binding of [35S]GTPgammaS was differentially affected by this treatment: increased in DRN and decreased in hippocampal dentate gyrus.
Positive_regulation (increased) of GTPgammaS Binding (binding) of in dentate gyrus
12) Confidence 0.31 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18809415 Disease Relevance 0 Pain Relevance 0.84
Sumatriptan dimer (10 microM) stimulated [35S]GTPgammaS binding mainly in the superficial gray layer of the superior colliculi, hippocampus and substantia nigra of guinea-pig and rat coronal brain sections.
Positive_regulation (stimulated) of GTPgammaS Binding (binding) of in brain associated with sumatriptan, substantia nigra and hippocampus
13) Confidence 0.27 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10101238 Disease Relevance 0 Pain Relevance 0.75
A commensurate reduction (to 29 +/- 10% of control) in the level of [35S]GTPgammaS binding stimulated by DAMGO was observed, but the t(1/2) for [35S]GTPgammaS binding remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of GTPgammaS Binding (binding) of
14) Confidence 0.25 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11408532 Disease Relevance 0.14 Pain Relevance 0.68
In this study agonist efficacy is defined by the degree to which an opioid stimulates the binding of [(35)S]GTPgammaS.
Positive_regulation (stimulates) of GTPgammaS Binding (binding) of associated with agonist and opioid
15) Confidence 0.20 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752111 Disease Relevance 0.08 Pain Relevance 0.85
Dense mu-stimulated [35S]GTPgammaS binding was also found in brainstem nuclei including the interpeduncular nucleus, parabrachial nucleus and nucleus of the solitary tract.
Positive_regulation (mu-stimulated) of GTPgammaS Binding (binding) of in parabrachial nucleus associated with medulla and parabrachial
16) Confidence 0.19 Published 1999 Journal Neuroscience Section Abstract Doc Link 10579225 Disease Relevance 0 Pain Relevance 0.92
L694247 caused little or no stimulation of [35S]GTPgammaS binding in brain regions with high densities of 5-HT(1B/D) binding sites (e.g., substantia nigra, striatum, central gray, and dorsal subiculum).
Neg (no) Positive_regulation (stimulation) of GTPgammaS Binding (binding) of in brain associated with substantia nigra
17) Confidence 0.17 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489749 Disease Relevance 0 Pain Relevance 0.45
Concentrations of agonists required to produce maximal stimulation of [35S]GTPgammaS binding were determined in membranes from the frontal poles of the brain.
Positive_regulation (stimulation) of GTPgammaS Binding (binding) of in brain associated with agonist
18) Confidence 0.17 Published 1999 Journal Neuroscience Section Abstract Doc Link 10579225 Disease Relevance 0 Pain Relevance 0.66
G protein activation mediated by serotonin 5-HT1A and 5-HT(1B/D) receptors in guinea pig brain was investigated by using quantitative autoradiography of agonist-stimulated [35S]GTPgammaS binding to brain sections. [35S]GTPgammaS binding was stimulated by the mixed 5-HT1A/5-HT(1B/D) agonist L694247 in brain structures enriched in 5-HT1A binding sites, i.e., hippocampus (+140 +/- 14%), dorsal raphe (+70 +/- 8%), lateral septum (+52 +/- 12%), cingulate (+36 +/- 8%), and entorhinal cortex (+34 +/- 5%).
Positive_regulation (stimulated) of GTPgammaS Binding (binding) of in brain associated with agonist, hippocampus, raphe and serotonin
19) Confidence 0.15 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489749 Disease Relevance 0 Pain Relevance 0.38
In contrast to its inhibitory effects on DAMGO-induced GTP gamma S binding, buprenorphine stimulated N/OFQ-induced GTP gamma S binding in male P2 nucleus accumbens and lateral septum.
Positive_regulation (induced) of GTP gamma S in lateral Binding (binding) of in nucleus accumbens associated with nucleus accumbens and buprenorphine
20) Confidence 0.11 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.11 Pain Relevance 1.79

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