INT72013

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.09
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

GTPase activity (Gnai2) cytoplasm (Gnai2) signal transducer activity (Gnai2)
cell proliferation (Gnai2) cytosol (Gnai2) nucleus (Gnai2)
Anatomy Link Frequency
tail 2
shell 1
artery 1
Gnai2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 7 99.68 Very High Very High Very High
gABA 5 99.38 Very High Very High Very High
dopamine receptor 2 99.26 Very High Very High Very High
tolerance 4 99.20 Very High Very High Very High
Morphine 16 99.08 Very High Very High Very High
Catecholamine 3 95.44 Very High Very High Very High
agonist 14 94.36 High High
opioid receptor 2 91.72 High High
Analgesic 1 90.60 High High
analgesia 1 85.76 High High
Disease Link Frequency Relevance Heat
Apoptosis 1 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration.
Negative_regulation (down-regulated) of Galphai2 in shell associated with nucleus accumbens, gaba, dopamine receptor and morphine
1) Confidence 0.35 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.23
Western blot analyses of G protein alpha and beta subunits demonstrated that Galphaq and Galphai protein levels were decreased in PE-exposed tail artery membranes.
Negative_regulation (decreased) of Galphai protein in tail
2) Confidence 0.24 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.07
Heterologous desensitization of the rat tail artery contraction and inositol phosphate accumulation after in vitro exposure to phenylephrine is mediated by decreased levels of Galphaq and Galphai.
Negative_regulation (decreased) of Galphai in artery
3) Confidence 0.24 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.33
These data show that the reduced transmembrane signaling for the alpha1AR in tail artery after in vitro PE exposure is associated with decreases in Galphaq and Galphai protein levels.
Negative_regulation (decreases) of Galphai protein in tail
4) Confidence 0.21 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.04
Impairing the activity of Galphaz but not Galphai2 subunits prevented tolerance developing after the administration of three consecutive doses of morphine.
Negative_regulation (Impairing) of Galphai2 associated with tolerance and morphine
5) Confidence 0.05 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15617734 Disease Relevance 0 Pain Relevance 0.77

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox