INT72017

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Context Info
Confidence 0.07
First Reported 1997
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg) plasma membrane (Adora2a) enzyme binding (Adora2a)
signal transducer activity (Adora2a)
Adora2a (Rattus norvegicus)
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
opiate 2 98.86 Very High Very High Very High
gABA 2 98.60 Very High Very High Very High
Neurotransmitter 6 98.14 Very High Very High Very High
Serotonin 2 68.76 Quite High
Clonidine 1 60.48 Quite High
Catecholamine 1 43.08 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the coupling of A2AR to G proteins using agonist-stimulated [35S]GTPgammaS binding as a functional assay.
A2AR Binding (binding) of GTPgammaS associated with agonist
1) Confidence 0.07 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.21
Basal [35S]GTPgammaS binding and [35S]GTPgammaS binding stimulated by other neurotransmitter receptor systems (GABA-B, mu opiate, and muscarinic) increase with a time course similar to A2AR-stimulated [35S]GTPgammaS binding.
A2AR Binding (binding) of GTPgammaS associated with gaba, neurotransmitter and opiate
2) Confidence 0.07 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.35
In control membranes alpha1AR stimulation increased [35S]GTPgammaS binding to Galphaq and Galphai proteins, whereas the alpha2AR agonist UK14,304 activated [35S]GTPgammaS binding to Galphai exclusively.
alpha2AR Binding (binding) of GTPgammaS associated with agonist
3) Confidence 0.00 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.21

General Comments

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