INT72021

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.13
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
coronary artery 1
posterior pituitary 1
nociceptor 1
Ednra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 17 100.00 Very High Very High Very High
nociceptor 4 99.44 Very High Very High Very High
antagonist 11 96.92 Very High Very High Very High
tetrodotoxin 4 96.08 Very High Very High Very High
Pain 7 95.48 Very High Very High Very High
nMDA receptor 8 95.32 Very High Very High Very High
gABA 5 93.48 High High
anticonvulsant 3 90.72 High High
cocaine 47 87.64 High High
agonist 6 78.72 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 12 96.40 Very High Very High Very High
Stress 48 95.52 Very High Very High Very High
Pain 4 95.48 Very High Very High Very High
Heart Rate Under Development 2 95.08 Very High Very High Very High
Hyperlipidemia 11 95.04 Very High Very High Very High
Diabetes Mellitus 29 94.40 High High
Pressure And Volume Under Development 18 94.04 High High
Increased Venous Pressure Under Development 27 93.48 High High
Coronary Artery Disease 2 91.80 High High
Renal Failure 1 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of these studies was to examine the role of ET receptor subtypes at hypothalamic vs. neurohypophysial sites on somatodendritic and neurohypophysial AVP secretion.
Localization (secretion) of ET receptor
1) Confidence 0.58 Published 2004 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 14665445 Disease Relevance 0 Pain Relevance 0.04
Activation of ET(A) receptors at the hypothalamic level inhibited, whereas ET(A) receptor activation at the posterior pituitary stimulated, neurohypophysial AVP secretion.
Localization (secretion) of ET in posterior pituitary
2) Confidence 0.55 Published 2004 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 14665445 Disease Relevance 0 Pain Relevance 0.14
Antagonism of hypothalamic ET(A) receptors potentiated the stimulatory effect of ET-1 and ET-3 on neurohypophysial secretion, an effect not observed with ET(B) receptor-induced somatodendritic release of AVP.
Localization (release) of ET
3) Confidence 0.48 Published 2004 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 14665445 Disease Relevance 0 Pain Relevance 0.12
Our method of real-time monitoring of dopamine release from rat striatal slices revealed that endothelin (ET)-3-induced dopamine release was inhibited by NG-methyl-L-arginine (L-NMMA; 1 mM), an inhibitor of nitric oxide (NO) synthase, while NG-methyl-D-arginine (D-NMMA; 1 mM), an inactive isomer of L-NMMA, had no effect. 2.
Localization (release) of ET associated with dopamine
4) Confidence 0.44 Published 1997 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 9353589 Disease Relevance 0.07 Pain Relevance 0.18
ETA appears to be at the center in modulating the vascular activity, and an upregulated ETA has been found under multiple conditions: congestive heart failure, hypertension, atherosclerosis, endothelial dysfunction, coronary artery diseases, renal failure, cerebrovascular disease, pulmonary arterial hypertension, and sepsis.3 Interestingly, some substances and prescriptions in Traditional Chinese Medicine (TCM) may be effective in reversing endothelial insults by suppressing the activated ETA, such as quercetin, isorhamnetin, or chelerythrine (protein kinase C (PKC) inhibitor), a modified rehmannia decoction (Liu-wei-di-huang decoction), and total triterpene acids isolated from corni fructus.1,4,5
Localization (appears) of ETA in coronary artery associated with pressure and volume under development, heart rate under development, coronary artery disease, renal failure, increased venous pressure under development, sepsis, cerebrovascular disease, kinase c and pulmonary hypertension
5) Confidence 0.36 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.90 Pain Relevance 0.11
Thus, it is possible that some of the stressor-like effects caused by these convulsant drugs could also be attenuated by EtOH.
Localization (attenuated) of EtOH
6) Confidence 0.06 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137594 Disease Relevance 0.77 Pain Relevance 0.48
These results demonstrate that ET-1 induces dose- and ETA receptor-dependent release of Ca2+in in nociceptor-like neurons, and permit further examination of the pathways that underlie ET-1-induced pain signaling.
Localization (release) of ETA receptor in nociceptor associated with pain and nociceptor
7) Confidence 0.02 Published 2001 Journal Neuroreport Section Abstract Doc Link 11726808 Disease Relevance 0.32 Pain Relevance 0.47

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