INT72024

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.22
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (EDNRA) signal transduction (EDNRA) aging (EDNRA)
plasma membrane (EDNRA) signal transducer activity (EDNRA)
Anatomy Link Frequency
plasma 2
urine 2
blood vessels 1
cleavage 1
smooth muscle cells 1
EDNRA (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 3 100.00 Very High Very High Very High
Dopamine 2 100.00 Very High Very High Very High
Neuropeptide 4 98.56 Very High Very High Very High
ischemia 3 90.40 High High
antagonist 65 87.84 High High
tetrodotoxin 1 78.08 Quite High
Peripheral nervous system 1 77.40 Quite High
medulla 2 76.72 Quite High
Calcitonin gene-related peptide 2 75.00 Quite High
Inflammation 10 69.04 Quite High
Disease Link Frequency Relevance Heat
Parathyroid Cancer 3 99.68 Very High Very High Very High
Reprotox - General 1 16 99.34 Very High Very High Very High
Increased Venous Pressure Under Development 41 99.28 Very High Very High Very High
Papillomavirus Infection 4 98.96 Very High Very High Very High
Chronic Disease 1 98.68 Very High Very High Very High
Osteoporosis 68 98.60 Very High Very High Very High
Injury 9 96.88 Very High Very High Very High
Hypercalcemia 22 96.56 Very High Very High Very High
Diuresis 4 96.52 Very High Very High Very High
Natriuresis 5 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the vasculature, ETA receptors are located on smooth muscle cells (SMCs) and fibroblasts, whereas ETB receptors are predominantly localized on endothelial cells and, to a lesser extent, on SMCs, fibroblasts, and macrophages.
Localization (localized) of ETA in smooth muscle cells
1) Confidence 0.57 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.74 Pain Relevance 0.03
ET-1 is released principally from endothelial cells that line blood vessels, but also from other vascular and non-vascular cells.
Localization (released) of ET in blood vessels
2) Confidence 0.57 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.56 Pain Relevance 0.10
Human papillomavirus (HPV)-positive human cervical carcinoma cell lines overexpress ET-1 and ETAR mRNA and secrete ET-1 protein compared to HPV-negative cells.
Localization (secrete) of ETAR mRNA associated with papillomavirus infection and reprotox - general 1
3) Confidence 0.45 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 2.30 Pain Relevance 0.13
We have therefore measured the release of this peptide and another sensory peptide [Substance P (SP)]; a vasoconstrictor peptide [Endothelin (ET)]; and a perivascular peptide [Neuropeptide Y (NPY)], within 24 hours of injury, in the plasma of patients with soft tissue injury.
Localization (release) of Endothelin in plasma associated with soft tissue injuries, injury, neuropeptide and substance p
4) Confidence 0.22 Published 1999 Journal Life Sci. Section Abstract Doc Link 10503954 Disease Relevance 0.74 Pain Relevance 0.42
On the contrary blockage of ET-A receptors are reported to cause osteopenia in experimental studies [24].
Localization (blockage) of ET associated with osteoporosis
5) Confidence 0.05 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1242236 Disease Relevance 0.63 Pain Relevance 0
Although it is known by many studies that [27,33,34] increased level of ET concentrations can be detected in the plasma as a result of overproduction of ET released from pathologic tissues and/or due to hypervascularization associated with the lesion in osseous or non-osseous pathologies, it can be thought that systemic circulation may thus not entirely reflect local changes in the bones.
Localization (released) of ET in plasma
6) Confidence 0.05 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1242236 Disease Relevance 0.38 Pain Relevance 0
Furthermore ET inhibits parathyroid hormone secretion in the parathyroid adenoma cells [18].
Localization (secretion) of ET in parathyroid associated with parathyroid cancer
7) Confidence 0.05 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1242236 Disease Relevance 0.62 Pain Relevance 0
Our method of real-time monitoring of dopamine release from rat striatal slices revealed that endothelin (ET)-3-induced dopamine release was inhibited by NG-methyl-L-arginine (L-NMMA; 1 mM), an inhibitor of nitric oxide (NO) synthase, while NG-methyl-D-arginine (D-NMMA; 1 mM), an inactive isomer of L-NMMA, had no effect. 2.
Localization (release) of endothelin associated with dopamine
8) Confidence 0.02 Published 1997 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 9353589 Disease Relevance 0.07 Pain Relevance 0.18
An activated form of ETA is released into the cytosol following furin cleavage where it inhibits protein synthesis ultimately leading to cell death (Perentesis et al 1992; Pastan et al 2006).
Localization (released) of ETA in cleavage associated with death
9) Confidence 0.02 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761172 Disease Relevance 0.91 Pain Relevance 0.03
Despite the higher concentration of ET in urine compared to plasma, the urinary excretion of ET does not correlate with the glomerular filtration rate filtered load or plasma levels [24].
Localization (excretion) of ET in urine
10) Confidence 0.01 Published 2008 Journal BMC Pediatr Section Body Doc Link PMC2542358 Disease Relevance 0.35 Pain Relevance 0.04
ET/creatinine ratio in random urine samples could be used as a reliable index of urinary excretion of ET [25,26].
Localization (excretion) of ET in urine
11) Confidence 0.01 Published 2008 Journal BMC Pediatr Section Body Doc Link PMC2542358 Disease Relevance 0.93 Pain Relevance 0.03

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