INT72040

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 3.57
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dendrites 2
growth cone 1
neurons 1
bands 1
sensory systems 1
L1cam (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 6 99.10 Very High Very High Very High
dorsal root ganglion 74 98.68 Very High Very High Very High
Substantia nigra 56 97.60 Very High Very High Very High
nMDA receptor 12 97.32 Very High Very High Very High
hypoalgesia 1 94.40 High High
Hippocampus 40 93.76 High High
Neurotransmitter 3 92.52 High High
Dorsal horn 11 91.56 High High
amygdala 55 91.28 High High
Periaqueductal grey 30 90.56 High High
Disease Link Frequency Relevance Heat
Immunization 24 100.00 Very High Very High Very High
Ganglion Cysts 76 98.68 Very High Very High Very High
Adhesions 22 98.32 Very High Very High Very High
Shock 44 97.68 Very High Very High Very High
Nociception 6 96.60 Very High Very High Very High
Hypoalagesia 1 94.40 High High
Urological Neuroanatomy 37 90.56 High High
Intellectual Impairment 1 89.84 High High
Cancer 8 85.04 High High
Metastasis 2 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L1 is involved in various recognition processes in the CNS and PNS, and binding to L1 can activate signal transduction pathways.
L1 Binding (binding) of
1) Confidence 0.48 Published 1997 Journal Nat. Genet. Section Abstract Doc Link 9354804 Disease Relevance 0.40 Pain Relevance 0.06
If there is direct interaction between L1 immunoreactive nerve terminals and dopaminergic neurons, such dopaminergic neurons might receive survival signals via synaptic connection.
L1 Binding (interaction) of in dopaminergic neurons
2) Confidence 0.48 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.18
Such areas are of common neurophysiological significance, i.e. the limbic and sensory systems, and therefore, L1 is considered to be closely associated with these systems.
L1 Binding (associated) of in sensory systems
3) Confidence 0.48 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.17 Pain Relevance 0.36
Thus, both antibodies are highly specific to the L1 protein.


L1 Binding (specific) of
4) Confidence 0.37 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.03
L1-positive nerve terminals in the reticular part may possibly associate with dendrites of dopaminergic neurons.
L1 Binding (associate) of in dendrites
5) Confidence 0.32 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.19
The antiFLL1 antibody, whose specificity was well-established in another study [2], recognized three bands in the neuropil fraction; the 200-kDa full-length L1, and the 140-kDa N-terminal and 80-kDa C-terminal fragments of L1 (Fig. 1a, lane 1).
L1 Binding (recognized) of in bands
6) Confidence 0.31 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.12 Pain Relevance 0.11
In view of the known interactions between L1 and some of the NMDA-receptor subtypes, and the prominent role of NMDA receptors in nociception and plasticity, it is conceivable that the hypoalgesia seen in L1 mutants is due, in part, to disturbed NMDA-receptor function.
L1 Binding (interactions) of associated with nociception, nmda receptor and hypoalgesia
7) Confidence 0.31 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591122 Disease Relevance 0.77 Pain Relevance 0.44
These cells, but not GFP+ cells, express GABA (Figure 2C) and thus, most likely represent L1 interneurons.
L1 Binding (interneurons) of in interneurons associated with gaba
8) Confidence 0.14 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.05
Ethanol directly binds to L1CAM at a critical domain interface [132] and disrupts its signaling cascade [133], suggesting that cell adhesion molecules are targets of ethanol.
L1CAM Binding (binds) of associated with adhesions
9) Confidence 0.13 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0.37 Pain Relevance 0.15
L1 is another component of the Sema3A receptor complex, and recycling of L1 is necessary for axon growth in DRG neurons [42].
L1 Binding (recycling) of in neurons associated with dorsal root ganglion
10) Confidence 0.10 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.43 Pain Relevance 0.09
CRMP2 is phosphorylated on threonine-555 by Rho kinase in response ephrinA5, and this blocked its tubulin binding and L1 endocytosis promoting properties, leading to growth cone collapse [43].
L1 Binding (binding) of in growth cone associated with shock
11) Confidence 0.10 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.42 Pain Relevance 0.08
Both superficial and deep L5 neurons had dense basal dendrites and a single apical dendrite extending to L1, and L6 neurons had apical dendrites that did not extend to L1; in some cases, these were inverted pyramids (Figure 3A).
L1 Neg (not) Binding (extend) of in dendrite
12) Confidence 0.08 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.03
Based on the observation that endogenous retroviral sequences such as L1 can induce specific signalling molecules, including p38?
L1 Binding (endogenous) of
13) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.45 Pain Relevance 0.20
Thönes et. al. [39] estimate that immunization with L1-pentamers also requires 20–40 fold more protein administered to obtain similar antibody response.
L1-pentamers Binding (immunization) of associated with immunization
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956639 Disease Relevance 0.43 Pain Relevance 0

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