INT72042

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2003
Negated 1
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 1.80
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
proximal 1
nervous system 1
neural 1
L1cam (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 8 99.84 Very High Very High Very High
substance P 6 90.48 High High
Neuropeptide 2 89.16 High High
amygdala 11 79.72 Quite High
Pain 3 76.56 Quite High
Substantia nigra 11 56.56 Quite High
primary afferent fibers 2 52.16 Quite High
Dorsal horn 4 50.44 Quite High
nMDA receptor 2 37.96 Quite Low
hypoalgesia 2 35.04 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 8 100.00 Very High Very High Very High
Nociception 12 99.74 Very High Very High Very High
Intellectual Impairment 1 86.56 High High
Paraplegia 1 80.56 Quite High
Hydrocephalus 1 79.60 Quite High
Pain 3 76.56 Quite High
Fasciculation 1 58.88 Quite High
Urological Neuroanatomy 7 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Hypoalagesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the adhesion molecule L1 is known to play an important role in neural development and synaptic plasticity, we studied the nociceptive withdrawal reflexes in awake adult mutant mice deficient in L1.
Negative_regulation (deficient) of L1 in neural associated with nociception, withdrawal and adhesions
1) Confidence 0.42 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591122 Disease Relevance 0.65 Pain Relevance 0.24
Heat nociception is severely reduced in a mutant mouse deficient for the L1 adhesion molecule.
Negative_regulation (reduced) of L1 adhesion molecule associated with nociception and adhesions
2) Confidence 0.42 Published 2003 Journal Brain Res. Section Title Doc Link 12591122 Disease Relevance 0.68 Pain Relevance 0.27
Disruption of the mouse L1 gene leads to malformations of the nervous system.
Negative_regulation (Disruption) of L1 in nervous system
3) Confidence 0.37 Published 1997 Journal Nat. Genet. Section Title Doc Link 9354804 Disease Relevance 0.48 Pain Relevance 0.07
It was found that there was no accumulation of L1 on the proximal side of the transected nerve (Fig. 2a,2a'), and no reduction of L1 on the distal side of the lesion (Fig. 2c,2c') or in the terminal field (data not shown).
Neg (no) Negative_regulation (reduction) of L1 in proximal
4) Confidence 0.37 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.25

General Comments

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