INT7205

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 65
Total Number 68
Disease Relevance 40.35
Pain Relevance 6.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG1) transport (HBG1)
Anatomy Link Frequency
erythrocytes 6
red blood cells 5
plasma 3
leukocyte 2
bone marrow 1
HBG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 76 99.90 Very High Very High Very High
anesthesia 30 99.60 Very High Very High Very High
abdominal pain 3 98.60 Very High Very High Very High
aspirin 13 97.84 Very High Very High Very High
gABA 86 96.92 Very High Very High Very High
Pain 140 96.76 Very High Very High Very High
Crohn's disease 2 95.24 Very High Very High Very High
cva 23 95.12 Very High Very High Very High
backache 1 94.84 High High
Dismenorea 34 94.08 High High
Disease Link Frequency Relevance Heat
Nicotine Addiction 58 99.98 Very High Very High Very High
Endometriosis 48 99.92 Very High Very High Very High
Hypertension 46 99.92 Very High Very High Very High
Reprotox - General 3 31 99.92 Very High Very High Very High
Anaemia 169 99.90 Very High Very High Very High
INFLAMMATION 69 99.90 Very High Very High Very High
Leukocytosis 3 99.64 Very High Very High Very High
Renal Disease 37 99.48 Very High Very High Very High
Inflammatory Bowel Disease 49 99.42 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

2 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Embolization of left renal artery was effective to relieve patient's symptom and to stabilize the serum hemoglobin level.
Positive_regulation (stabilize) of serum hemoglobin in left renal artery
1) Confidence 0.69 Published 2005 Journal Hinyokika Kiyo Section Abstract Doc Link 15852671 Disease Relevance 0.72 Pain Relevance 0.12
Intraoperative near-infrared monitoring showed an increase in the concentration of total and oxidized hemoglobin in the left frontal area after stenting.
Positive_regulation (increase) of hemoglobin in frontal area
2) Confidence 0.69 Published 2003 Journal No Shinkei Geka Section Abstract Doc Link 14719446 Disease Relevance 0.77 Pain Relevance 0.20
The mean hemoglobin level in the three compliant children increased to 138 gm/L (13.8 gm/dl) after treatment.
Positive_regulation (increased) of hemoglobin
3) Confidence 0.64 Published 1998 Journal J. Pediatr. Section Abstract Doc Link 9470019 Disease Relevance 0.51 Pain Relevance 0.16
Majority of the respondents agree with the universal preoperative requirement of at least 10 gm% hemoglobin and minimum weight of 4-5 kgs in CLP.
Positive_regulation (requirement) of hemoglobin
4) Confidence 0.59 Published 2010 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2938628 Disease Relevance 0.26 Pain Relevance 0
Our observations are summarized in that treatment with hydroxyrea results in a significant increase of fetal hemoglobin with no change of the total hemoglobin levels.
Positive_regulation (increase) of hemoglobin
5) Confidence 0.59 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668534 Disease Relevance 0.43 Pain Relevance 0
The drug causes also a considerable increase of the erythrocyte volume and hemoglobin content while the MCHC values remain unchanged.
Positive_regulation (increase) of hemoglobin in erythrocyte
6) Confidence 0.45 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668534 Disease Relevance 0.52 Pain Relevance 0.05
In contrast, hydroxyurea treatment was associated with a 1.5-fold to sevenfold increase in F cells and a 2.3- to 27-fold increase in the percentage of Hb F.
Positive_regulation (increase) of Hb F
7) Confidence 0.45 Published 1992 Journal Semin. Oncol. Section Abstract Doc Link 1379376 Disease Relevance 0.39 Pain Relevance 0.05
In conclusion, prilocaine anesthesia leads to a massive increase of hemoglobin adducts of the carcinogenic arylamine o-toluidine.
Positive_regulation (increase) of hemoglobin associated with anesthesia
8) Confidence 0.44 Published 2007 Journal Toxicology Section Abstract Doc Link 17129655 Disease Relevance 0.18 Pain Relevance 0.23
Hemoglobin adducts of o-toluidine were significantly increased 24h after 100mg prilocaine-treatment by 21.6+/-12.8ng/g hemoglobin (mean+/-S.D., N=26; P<0.0001).
Positive_regulation (increased) of Hemoglobin
9) Confidence 0.44 Published 2007 Journal Toxicology Section Abstract Doc Link 17129655 Disease Relevance 0.06 Pain Relevance 0.25
Within these areas it stimulates: muscle growth and maintenance, bone development while inhibiting bone resorption, the production of red blood cells to increase hemoglobin, libido, enhanced mood and cognition, erectile function and lipolysis.
Positive_regulation (increase) of hemoglobin in red blood cells associated with cognitive disorder, reprotox - general 3 and hypercalcemia
10) Confidence 0.35 Published 2010 Journal Maturitas Section Abstract Doc Link 20153946 Disease Relevance 1.72 Pain Relevance 0.09
A 30-year-old man visited our emergency department because of abdominal pain, and was admitted to our hematology department because of a markedly increased hemoglobin concentration reaching 26.2 g/dl.
Positive_regulation (increased) of hemoglobin associated with abdominal pain and emergencies
11) Confidence 0.33 Published 2002 Journal Rinsho Ketsueki Section Abstract Doc Link 11925875 Disease Relevance 1.11 Pain Relevance 0.13
At 6-month follow-up, the patient continued to have elevated glycosylated hemoglobin, hypertension, dyslipidemia, and excess weight.
Positive_regulation (elevated) of hemoglobin associated with hypertension
12) Confidence 0.33 Published 2008 Journal J Am Osteopath Assoc Section Abstract Doc Link 18519838 Disease Relevance 1.09 Pain Relevance 0.21
Effectiveness was assessed by increase in hemoglobin and hematocrit and changes of iron parameters.
Positive_regulation (increase) of hemoglobin
13) Confidence 0.33 Published 1999 Journal Am. J. Kidney Dis. Section Abstract Doc Link 10070911 Disease Relevance 0 Pain Relevance 0
In the neonates mean methemoglobin concentrations were about 1% of total hemoglobin immediately after delivery, increasing up to 1.8% in the next 2 h and then decreasing continuously in all.
Positive_regulation (increasing) of hemoglobin
14) Confidence 0.33 Published 1989 Journal Reg Anaesth Section Abstract Doc Link 2772273 Disease Relevance 0.54 Pain Relevance 0.41
These measures were expected to increase her hemoglobin levels and accelerate red cell production.
Positive_regulation (increase) of hemoglobin
15) Confidence 0.28 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2991319 Disease Relevance 0.20 Pain Relevance 0.04
The administration of ferrous fumarate, folic acid, recombinant erythropoietin and G-CSF helped to maintain the hemoglobin and white cell counts during the course of chemotherapy and enhanced the preoperative hemoglobin levels to 13.5 g/dL.
Positive_regulation (enhanced) of hemoglobin
16) Confidence 0.28 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2991319 Disease Relevance 0.45 Pain Relevance 0.03
High-dose i.v. treatment with 1.0 g sodium ferric gluconate complex in sucrose resulted in significantly greater improvement in hemoglobin, hematocrit, iron saturation, and serum ferritin at all time points, as compared with low-dose i.v. (0.5 g) or oral iron treatment.
Positive_regulation (improvement) of hemoglobin
17) Confidence 0.24 Published 1999 Journal Am. J. Kidney Dis. Section Abstract Doc Link 10070911 Disease Relevance 0.28 Pain Relevance 0.08
Clinical studies have shown that effectively treating anemia and increasing hemoglobin levels using recombinant human erythropoietin (rHuEPO, epoetin alfa) has a significant effect on transfusion requirements and quality of life.
Positive_regulation (increasing) of hemoglobin associated with anaemia
18) Confidence 0.23 Published 2002 Journal Semin. Oncol. Section Abstract Doc Link 12082653 Disease Relevance 1.81 Pain Relevance 0.16
The DNA methyltransferase (DNMT) inhibitors 5-azacytidine and 5-aza-2'deoxycyidine (decitabine) have been shown to increase fetal hemoglobin levels in clinical trials in patients with sickle cell disease [3-6].
Positive_regulation (increase) of hemoglobin associated with sickle cell anemia
19) Confidence 0.21 Published 2010 Journal J Transl Med Section Body Doc Link PMC2958909 Disease Relevance 0.74 Pain Relevance 0.09
Therefore pharmacological agents that can elevate fetal hemoglobin have great potential as therapeutic agents.
Positive_regulation (elevate) of hemoglobin
20) Confidence 0.21 Published 2010 Journal J Transl Med Section Body Doc Link PMC2958909 Disease Relevance 0.65 Pain Relevance 0.10

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