INT72052

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Context Info
Confidence 0.54
First Reported 1997
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.82
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTA2) small molecule metabolic process (GSTA2) cytoplasm (GSTA2)
Anatomy Link Frequency
tubules 2
plasma 1
GSTA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 5 75.00 Quite High
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Albuminuria 2 100.00 Very High Very High Very High
Nephrotoxicity 2 86.24 High High
Injury 18 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously demonstrated in humans that a 2-L/min flow rate delivery of 1.25 minimum alveolar anesthetic concentration (MAC) sevoflurane for 8 h can injure glomeruli (i.e., produce albuminuria) and proximal tubules (i.e., produce glucosuria and urinary excretion of alpha-glutathione-S-transferase [alpha-GST]).
Gene_expression (produce) of alpha-glutathione-S-transferase in tubules associated with albuminuria
1) Confidence 0.54 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9356118 Disease Relevance 0.41 Pain Relevance 0.14
We previously demonstrated in humans that a 2-L/min flow rate delivery of 1.25 minimum alveolar anesthetic concentration (MAC) sevoflurane for 8 h can injure glomeruli (i.e., produce albuminuria) and proximal tubules (i.e., produce glucosuria and urinary excretion of alpha-glutathione-S-transferase [alpha-GST]).
Gene_expression (produce) of alpha-GST in tubules associated with albuminuria
2) Confidence 0.52 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9356118 Disease Relevance 0.41 Pain Relevance 0.14
We measured plasma levels of alpha-GST, aspartate aminotransferase aspartate, alanine aminotransferase, alkaline phosphatase, pseudocholinesterase, gamma glutamyltransferase and total bilirubin at baseline and several times during and after surgery.
Gene_expression (levels) of alpha-GST in plasma
3) Confidence 0.21 Published 1999 Journal Rev Esp Anestesiol Reanim Section Body Doc Link 10563141 Disease Relevance 0 Pain Relevance 0

General Comments

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