INT72053

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 18
Disease Relevance 6.12
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTA2) small molecule metabolic process (GSTA2) cytoplasm (GSTA2)
Anatomy Link Frequency
plasma 2
tubules 2
urine 1
GSTA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 9 99.84 Very High Very High Very High
rheumatoid arthritis 6 99.76 Very High Very High Very High
cINOD 33 99.44 Very High Very High Very High
anesthesia 7 98.16 Very High Very High Very High
isoflurane 1 93.36 High High
peptic ulcer disease 4 86.72 High High
Potency 6 78.12 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 9 99.76 Very High Very High Very High
Disorders Of Creatine Metabolism 1 99.68 Very High Very High Very High
INFLAMMATION 9 99.16 Very High Very High Very High
Infection 16 99.12 Very High Very High Very High
Albuminuria 4 98.78 Very High Very High Very High
Ulcers 12 98.44 Very High Very High Very High
Disease 11 97.14 Very High Very High Very High
Hepatic Encephalopathy 4 92.68 High High
Enteropathy 4 91.44 High High
Injury 23 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that H. pylori infection and/or eradication treatment increased the releasing of alpha-glutathione S-transferase (alpha-GST).
Localization (releasing) of alpha-glutathione S-transferase associated with infection
1) Confidence 0.78 Published 2007 Journal Current drug safety Section Abstract Doc Link 18690949 Disease Relevance 0.88 Pain Relevance 0.09
Release of alpha-glutathione S-transferase (alpha-GST) and hepatocellular damage induced by Helicobacter pylori and eradication treatment.
Localization (Release) of alpha-glutathione S-transferase associated with ulcers
2) Confidence 0.69 Published 2007 Journal Current drug safety Section Title Doc Link 18690949 Disease Relevance 0.84 Pain Relevance 0.09
We hypothesized that H. pylori infection and/or eradication treatment increased the releasing of alpha-glutathione S-transferase (alpha-GST).
Localization (releasing) of alpha-GST associated with infection
3) Confidence 0.68 Published 2007 Journal Current drug safety Section Abstract Doc Link 18690949 Disease Relevance 0.88 Pain Relevance 0.09
We previously demonstrated in humans that a 2-L/min flow rate delivery of 1.25 minimum alveolar anesthetic concentration (MAC) sevoflurane for 8 h can injure glomeruli (i.e., produce albuminuria) and proximal tubules (i.e., produce glucosuria and urinary excretion of alpha-glutathione-S-transferase [alpha-GST]).
Localization (excretion) of alpha-glutathione-S-transferase in tubules associated with albuminuria
4) Confidence 0.63 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9356118 Disease Relevance 0.40 Pain Relevance 0.14
We previously demonstrated in humans that a 2-L/min flow rate delivery of 1.25 minimum alveolar anesthetic concentration (MAC) sevoflurane for 8 h can injure glomeruli (i.e., produce albuminuria) and proximal tubules (i.e., produce glucosuria and urinary excretion of alpha-glutathione-S-transferase [alpha-GST]).
Localization (excretion) of alpha-GST in tubules associated with albuminuria
5) Confidence 0.63 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9356118 Disease Relevance 0.41 Pain Relevance 0.14
Release of alpha-glutathione S-transferase (alpha-GST) and hepatocellular damage induced by Helicobacter pylori and eradication treatment.
Localization (Release) of alpha-GST associated with ulcers
6) Confidence 0.60 Published 2007 Journal Current drug safety Section Title Doc Link 18690949 Disease Relevance 0.84 Pain Relevance 0.09
OBJECTIVE: In this study, we compared the effects of etodolac and ibuprofen on renal function, plasma renin, plasma arginine vasopressin and the urinary excretion of albumin and alpha-glutathione-S-transferase (alpha-GST).
Localization (excretion) of alpha-glutathione-S-transferase in plasma
7) Confidence 0.50 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 11009046 Disease Relevance 0 Pain Relevance 0
A comparison of the effects of etodolac and ibuprofen on renal haemodynamics, tubular function, renin, vasopressin and urinary excretion of albumin and alpha-glutathione-S-transferase in healthy subjects: a placebo-controlled cross-over study.
Localization (excretion) of alpha-glutathione-S-transferase
8) Confidence 0.50 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 11009046 Disease Relevance 0.10 Pain Relevance 0.41
OBJECTIVE: In this study, we compared the effects of etodolac and ibuprofen on renal function, plasma renin, plasma arginine vasopressin and the urinary excretion of albumin and alpha-glutathione-S-transferase (alpha-GST).
Localization (excretion) of alpha-GST in plasma
9) Confidence 0.43 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 11009046 Disease Relevance 0 Pain Relevance 0
In addition, we examined the effects on the urinary excretion of albumin and alpha-GST as markers of renal injury.
Localization (excretion) of alpha-GST
10) Confidence 0.43 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 11009046 Disease Relevance 0 Pain Relevance 0
Fourteen days of treatment with ibuprofen caused a significant decrease (-47% versus placebo) in the urinary excretion of alpha-GST, while no changes were seen after etodolac.
Localization (excretion) of alpha-GST
11) Confidence 0.38 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 11009046 Disease Relevance 0 Pain Relevance 0
The reduction in the urinary excretion of alpha-GST by ibuprofen may be caused by an inhibition of the detoxification enzyme by ibuprofen.
Localization (excretion) of alpha-GST
12) Confidence 0.38 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 11009046 Disease Relevance 0 Pain Relevance 0
[Mobilization of alpha-glutathione S-transferase in the anesthetized patient].
Localization ([Mobilization) of alpha-glutathione S-transferase
13) Confidence 0.29 Published 1999 Journal Rev Esp Anestesiol Reanim Section Title Doc Link 10563141 Disease Relevance 0 Pain Relevance 0.14
We measured inspired and expired concentrations of Compound A and urinary excretion of albumin, alpha-glutathione-S-transferase (GST), and glucose.
Localization (excretion) of alpha-glutathione-S-transferase
14) Confidence 0.28 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 9972771 Disease Relevance 0.39 Pain Relevance 0.09
OBJECTIVE: To evaluate the effect of methotrexate (MTX) and other disease-modifying anti-rheumatic drugs (DMARDs) alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) on the urinary excretion of alpha-glutathione S-transferase (alpha-GST) and albumin in rheumatoid arthritis (RA) patients.
Localization (excretion) of alpha-glutathione S-transferase associated with inflammation, rheumatoid arthritis, cinod, disease and methotrexate
15) Confidence 0.16 Published 2005 Journal Scand. J. Rheumatol. Section Abstract Doc Link 15903023 Disease Relevance 0.47 Pain Relevance 0.45
Urinary excretion of alpha-GST and albumin in rheumatoid arthritis patients treated with methotrexate or other DMARDs alone or in combination with NSAIDs.
Localization (excretion) of alpha-GST associated with cinod, rheumatoid arthritis and methotrexate
16) Confidence 0.14 Published 2005 Journal Scand. J. Rheumatol. Section Title Doc Link 15903023 Disease Relevance 0.19 Pain Relevance 0.51
OBJECTIVE: To evaluate the effect of methotrexate (MTX) and other disease-modifying anti-rheumatic drugs (DMARDs) alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) on the urinary excretion of alpha-glutathione S-transferase (alpha-GST) and albumin in rheumatoid arthritis (RA) patients.
Localization (excretion) of alpha-GST associated with inflammation, rheumatoid arthritis, cinod, disease and methotrexate
17) Confidence 0.14 Published 2005 Journal Scand. J. Rheumatol. Section Abstract Doc Link 15903023 Disease Relevance 0.47 Pain Relevance 0.45
Creatinine clearance and fractional excretion of sodium, as well as urine concentrations of N-acetyl-beta-D-glucosaminidase, alpha-1-microglobulin, glutathione transferase-pi (GST-pi), and glutathione transferase-alpha (GST-alpha) were measured after induction of anesthesia, at the end of surgery, and at the first and second postoperative days (PODs) on the intensive care unit.
Localization (excretion) of glutathione transferase-alpha in urine associated with anesthesia and disorders of creatine metabolism
18) Confidence 0.02 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14633524 Disease Relevance 0.26 Pain Relevance 0.10

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