INT72097

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Context Info
Confidence 0.55
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.71
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (IFNGR2) plasma membrane (IFNGR2)
Anatomy Link Frequency
TEK 1
PBMC 1
IFNGR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 100.00 Very High Very High Very High
metalloproteinase 18 94.32 High High
Enkephalin 5 88.88 High High
Gabapentin 1 44.16 Quite Low
antagonist 6 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 121 98.02 Very High Very High Very High
Cancer 187 90.20 High High
Generaliased Trisomy 1 88.04 High High
Ductal Carcinoma 3 68.24 Quite High
Malignant Neoplastic Disease 6 65.24 Quite High
Stress 7 53.88 Quite High
Parkinson's Disease 7 53.04 Quite High
Breast Cancer 69 50.00 Quite Low
Apoptosis 115 48.00 Quite Low
Cognitive Disorder 4 27.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of IFNGR2
1) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.50 Pain Relevance 0.03
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (underexpression) of IFNGR2
2) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.51 Pain Relevance 0.03
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of IFNGR2 in TEK associated with metalloproteinase
3) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.67 Pain Relevance 0.05
in DS are likely to be related to the presence of several IFN receptor genes in chromosome 21 including IFNGR2, which is one of the subunits of the IFN-?
Gene_expression (one) of IFNGR2 associated with syndrome
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 1.03 Pain Relevance 0.05
By use of a quantitative reverse-transcriptase-polymerase chain reaction (RT-PCR), we demonstrate that the T helper 2 cytokines IL-4 and IL-10 are more potent in upregulating PPE mRNA expression in human PBMC than the T helper 1 cytokines IL-2 and gamma-IFN.
Gene_expression (expression) of gamma-IFN in PBMC associated with cytokine
5) Confidence 0.11 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9357452 Disease Relevance 0 Pain Relevance 0.43

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