INT72099

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.71
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
immune cell 2
T cells 2
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 37 100.00 Very High Very High Very High
opioid receptor 2 99.84 Very High Very High Very High
rheumatoid arthritis 107 99.80 Very High Very High Very High
mu opioid receptor 1 98.80 Very High Very High Very High
methotrexate 1 96.96 Very High Very High Very High
Enkephalin 5 94.16 High High
Endogenous opioid 1 93.76 High High
Morphine 1 92.72 High High
Leflunomide 1 77.76 Quite High
Inflammation 68 62.04 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 107 99.80 Very High Very High Very High
Autoimmune Disease 17 71.04 Quite High
INFLAMMATION 70 62.04 Quite High
Cancer 6 44.24 Quite Low
Necrosis 3 43.76 Quite Low
Arthritis 16 27.64 Quite Low
Disease 30 13.12 Low Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Psoriasis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this report we show that stimulation with interleukin-4 induces mu-opioid receptor transcripts in human primary blood cells (T cells and polymorphonuclear leukocytes), immune cell lines (Raji, U-937, and HMEC-1), and dendritic cells.
Positive_regulation (induces) of Positive_regulation (stimulation) of interleukin-4 in immune cell associated with opioid receptor
1) Confidence 0.43 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11572871 Disease Relevance 0 Pain Relevance 0.32
On the contrary, induction of IL-4 was even more pronounced for RA patients than for healthy controls.
Positive_regulation (pronounced) of Positive_regulation (induction) of IL-4 associated with rheumatoid arthritis
2) Confidence 0.40 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.45 Pain Relevance 0.22
We could observe that PKA is involved in IL-4 mediated PPE mRNA induction, whereas IL-10 apparently uses another route.
Positive_regulation (mediated) of Positive_regulation (induction) of IL-4
3) Confidence 0.34 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9357452 Disease Relevance 0 Pain Relevance 0.42
and increases the ability to induce the Th2 cytokine IL-4 in antigen-primed CD4+ T cells [87].
Positive_regulation (increases) of Positive_regulation (induce) of Th2 cytokine IL-4 in T cells associated with cytokine
4) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.26 Pain Relevance 0.27

General Comments

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