INT72110

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 48
Total Number 48
Disease Relevance 22.46
Pain Relevance 6.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Glp1r) signal transducer activity (Glp1r)
Anatomy Link Frequency
Plasma 5
neurons 5
intestinal epithelium 4
Substantia nigra pars compacta 4
nucleus 2
Glp1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 106 100.00 Very High Very High Very High
tolerance 398 99.62 Very High Very High Very High
Dopamine 16 99.62 Very High Very High Very High
Neuropeptide 70 99.40 Very High Very High Very High
Central nervous system 748 99.36 Very High Very High Very High
spastic colon 18 97.28 Very High Very High Very High
Substantia nigra 16 96.60 Very High Very High Very High
qutenza 3 95.72 Very High Very High Very High
vagus nerve 2 94.96 High High
antagonist 99 89.56 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 1166 100.00 Very High Very High Very High
Targeted Disruption 39 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 60 99.76 Very High Very High Very High
Diabetes Mellitus 588 99.72 Very High Very High Very High
Impaired Glucose Tolerance 406 99.62 Very High Very High Very High
Hyperinsulinism 71 99.60 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 97.28 Very High Very High Very High
Gastric Motility Disorder 7 96.96 Very High Very High Very High
Disease 138 96.56 Very High Very High Very High
Myocardial Infarction 106 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma was analysed for GLP-1 and gut hormones, and gut tissue expression of GLP-1 receptor was studied.
Gene_expression (expression) of GLP-1 receptor in Plasma
1) Confidence 0.78 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18298441 Disease Relevance 0.16 Pain Relevance 0.42
Presence of the GLP-1 receptor in the gut was verified by reverse transcriptase PCR.
Gene_expression (Presence) of GLP-1 receptor in gut
2) Confidence 0.67 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18298441 Disease Relevance 0.13 Pain Relevance 0.43
Plasma was analysed for GLP-1 and gut hormones, and gut tissue expression of GLP-1 receptor was studied.
Gene_expression (expression) of GLP-1 in Plasma
3) Confidence 0.67 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18298441 Disease Relevance 0.16 Pain Relevance 0.42
However, GLP-1 is also synthesized in a discrete population of neurons in the hindbrain (10–12), and GLP-1 receptors are highly expressed in various regions of the hypothalamus (13) including the arcuate nucleus (ARC) and the paraventricular nucleus (PVN) (14), two areas where immunoreactive GLP-1 fibers terminate (11).
Gene_expression (expressed) of GLP-1 in hypothalamus associated with aids-related complex
4) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.35 Pain Relevance 0.19
Consistent with a role for GLP-1 receptors in the arcuate, GLP-1 receptor mRNA was found to be expressed in 68.1% of arcuate neurons that expressed pro-opiomelanocortin mRNA but was not significantly coexpressed with neuropeptide tyrosine.
Gene_expression (expressed) of GLP-1 receptor mRNA in neurons associated with neuropeptide
5) Confidence 0.67 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494674 Disease Relevance 0.36 Pain Relevance 0.26
Further, since circulating GLP-1 is not increased during glucose tolerance tests, peripheral GLP-1 may not be the important source of GLP-1 activating the CNS receptors that regulate islet and hepatic function.
Gene_expression (source) of GLP-1 associated with tolerance, central nervous system and impaired glucose tolerance
6) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.65 Pain Relevance 0.36
Finally, using dual in situ hybridization histochemistry, we evaluated ARC GLP-1 receptor expression on orexigenic neuropeptide tyrosine (NPY) and anorexigenic proopiomelanocortin (POMC) neurons.
Gene_expression (expression) of ARC GLP-1 receptor in neurons associated with aids-related complex and neuropeptide
7) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.58 Pain Relevance 0.31
One population, found predominantly in the medio-lateral part of the ARC, coexpressed GLP-1 receptor mRNA.
Gene_expression (coexpressed) of GLP-1 receptor mRNA in lateral associated with aids-related complex
8) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.65 Pain Relevance 0
However, GLP-1 is also synthesized in a discrete population of neurons in the hindbrain (10–12), and GLP-1 receptors are highly expressed in various regions of the hypothalamus (13) including the arcuate nucleus (ARC) and the paraventricular nucleus (PVN) (14), two areas where immunoreactive GLP-1 fibers terminate (11).
Gene_expression (synthesized) of GLP-1 in hypothalamus associated with aids-related complex
9) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.34 Pain Relevance 0.18
In the retrochiasmatic nucleus, an average of 40.0 ± 10.7% of the POMC neurons also coexpressed GLP-1 receptor mRNA, whereas in the ARC, an average of 68.1 ± 2.7% of the POMC neurons located in the medio-lateral part of the nucleus expressed GLP-1 receptor as well (Table 2 and Fig. 3D–F).
Gene_expression (coexpressed) of GLP-1 receptor mRNA in nucleus associated with aids-related complex
10) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.53 Pain Relevance 0.03
Expression of ARC GLP-1 receptor mRNA in NPY and POMC neurons.
Gene_expression (Expression) of ARC GLP-1 receptor mRNA in neurons associated with aids-related complex
11) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.47 Pain Relevance 0.10
Prominent among these is glucagon-like peptide-1 (GLP-1), which is produced by L-cells of the ileum and is secreted during meal ingestion.
Gene_expression (produced) of GLP-1 in ileum
12) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.14 Pain Relevance 0.04
Further, since circulating GLP-1 is not increased during glucose tolerance tests, peripheral GLP-1 may not be the important source of GLP-1 activating the CNS receptors that regulate islet and hepatic function.
Gene_expression (source) of GLP-1 associated with tolerance, central nervous system and impaired glucose tolerance
13) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.65 Pain Relevance 0.36
Because GLP-1 is also synthesized in the brain, where it regulates food intake, we hypothesized that the central GLP-1 system regulates glucose tolerance as well.
Gene_expression (synthesized) of GLP-1 in brain associated with tolerance and impaired glucose tolerance
14) Confidence 0.67 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494674 Disease Relevance 0.26 Pain Relevance 0.19
The other population was found at the lateral edge of the nucleus and largely did not coexpress GLP-1 receptors (Fig. 4A, B, and D).
Neg (not) Gene_expression (coexpress) of GLP-1 in lateral
15) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.69 Pain Relevance 0.03
GLP-1 receptor–expressing cells are also more numerous in the caudal ARC (large arrows in Fig. 4B and D), specifically in its medial posterior part.
Gene_expression (expressing) of GLP-1 receptor in posterior associated with aids-related complex
16) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.65 Pain Relevance 0.06
These results support the notion that GLP-1 receptors participate in the central and peripheral regulation of gastric function.
Gene_expression (participate) of GLP-1
17) Confidence 0.67 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9357836 Disease Relevance 0.07 Pain Relevance 0.07
DA: dopamine; EX-4: exendin-4; GLP-1: glucagon-like peptide 1; GLP-1R: glucagon-like peptide 1 receptor; LPS: lipopolysaccharide; 6-OHDA: 6-hydroxydopamine; TH: tyrosine hydroxylase; SNc: Substantia nigra pars compacta.


Gene_expression (receptor) of GLP-1 in Substantia nigra pars compacta associated with dopamine and substantia nigra
18) Confidence 0.62 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2426681 Disease Relevance 0.27 Pain Relevance 0.10
DA: dopamine; EX-4: exendin-4; GLP-1: glucagon-like peptide 1; GLP-1R: glucagon-like peptide 1 receptor; LPS: lipopolysaccharide; 6-OHDA: 6-hydroxydopamine; TH: tyrosine hydroxylase; SNc: Substantia nigra pars compacta.


Gene_expression (receptor) of GLP-1R in Substantia nigra pars compacta associated with dopamine and substantia nigra
19) Confidence 0.62 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2426681 Disease Relevance 0.26 Pain Relevance 0.10
DA: dopamine; EX-4: exendin-4; GLP-1: glucagon-like peptide 1; GLP-1R: glucagon-like peptide 1 receptor; LPS: lipopolysaccharide; 6-OHDA: 6-hydroxydopamine; TH: tyrosine hydroxylase; SNc: Substantia nigra pars compacta.


Gene_expression (receptor) of glucagon-like peptide 1 in Substantia nigra pars compacta associated with dopamine and substantia nigra
20) Confidence 0.62 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2426681 Disease Relevance 0.26 Pain Relevance 0.10

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