INT72114

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.40
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) response to stress (Gal)
cytoplasm (Gal)
Anatomy Link Frequency
dorsal horn 4
lactotrophs 2
gracile nucleus 2
Gal (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 21 100.00 Very High Very High Very High
Neuropeptide 15 100.00 Very High Very High Very High
Sciatic nerve 3 99.26 Very High Very High Very High
Dorsal horn 3 99.20 Very High Very High Very High
Spinal cord 5 95.56 Very High Very High Very High
gracile nuclei 1 94.84 High High
Neuropathic pain 2 93.16 High High
c fibre 1 87.12 High High
Peripheral nerve stimulation 1 85.84 High High
Eae 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 99.98 Very High Very High Very High
Diabetic Nephropathy 2 97.20 Very High Very High Very High
Neuropathic Pain 4 93.16 High High
Targeted Disruption 22 92.08 High High
Nociception 1 81.60 Quite High
Injury 5 75.80 Quite High
Hyperplasia 6 6.28 Low Low
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the antibody microprobe technique to study the localized sites of ir-galanin release in vivo, we found that high intensity electrical stimulation of the injured nerve resulted in a further increase in ir-galanin release in the superficial dorsal horn, with no significant persistence of ir-galanin after release.
Positive_regulation (increase) of Localization (release) of ir-galanin in dorsal horn associated with dorsal horn
1) Confidence 0.60 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9861137 Disease Relevance 0.25 Pain Relevance 0.46
On the side of the cord ipsilateral to the nerve injury enhanced ir-galanin release was found in the superficial dorsal horn.
Positive_regulation (enhanced) of Localization (release) of ir-galanin in dorsal horn associated with nervous system injury and dorsal horn
2) Confidence 0.41 Published 1997 Journal Brain Res. Section Abstract Doc Link 9359612 Disease Relevance 0.27 Pain Relevance 0.13
These results show that partial nerve injury to the sciatic nerve induces increases in the content of galanin, neuropeptide Y and calcitonin gene-related peptide immunoreactivities in synaptic terminals within the gracile nucleus, which suggests that there may be increased release of these neuropeptides following sensory or spontaneous stimulation of large-diameter primary afferents following partial nerve injury, perhaps one mechanism involved in neuropathic pain.
Spec (may) Positive_regulation (increased) of Localization (release) of galanin in gracile nucleus associated with nervous system injury, neuropathic pain, neuropeptide, sciatic nerve and calcitonin gene-related peptide
3) Confidence 0.29 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430497 Disease Relevance 0.64 Pain Relevance 0.94
Galanin-positive lactotrophs (identified by in situ hybridisation) release more PRL than galanin-negative lactotrophs, whereas galanin antiserum significantly blunts PRL secretion from galanin-positive cells.
Positive_regulation (blunts) of Localization (secretion) of galanin in lactotrophs
4) Confidence 0.08 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.24 Pain Relevance 0

General Comments

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