INT72123

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Context Info
Confidence 0.53
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.04
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
Paf (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 82 98.52 Very High Very High Very High
Inflammation 38 96.24 Very High Very High Very High
anesthesia 2 86.40 High High
Potency 2 58.68 Quite High
chemokine 35 5.00 Very Low Very Low Very Low
5HT 23 5.00 Very Low Very Low Very Low
metalloproteinase 15 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 93 98.52 Very High Very High Very High
INFLAMMATION 40 96.24 Very High Very High Very High
Thrombocytopenia 5 61.80 Quite High
Disease 30 25.96 Quite Low
Recurrence 2 9.44 Low Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Thrombosis 6 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 5 5.00 Very Low Very Low Very Low
Vasculitis 5 5.00 Very Low Very Low Very Low
Demyelinating Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The renin-angiotensin system increased in proportion to the decrease in PAF.
Positive_regulation (increased) of Negative_regulation (decrease) of PAF
1) Confidence 0.53 Published 1997 Journal ASAIO J. Section Abstract Doc Link 9360092 Disease Relevance 0 Pain Relevance 0.08
The prostaglandin E2 concentration increased from 1.5 +/- 0.6 to 8.8 +/- 0.6 pg/ml following the decrease in PAF from 100 to 0%.
Positive_regulation (increased) of Negative_regulation (decrease) of PAF
2) Confidence 0.44 Published 1997 Journal ASAIO J. Section Abstract Doc Link 9360092 Disease Relevance 0 Pain Relevance 0.09
Such a decrease of PAF-AH activity may in part be responsible for the reported increase of PAF in MS plasma and CSF, and therefore could contribute to the inflammation and vascular permeability changes seen in the CNS of MS.
Positive_regulation (responsible) of Negative_regulation (decrease) of PAF in plasma associated with multiple sclerosis and inflammation
3) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.04 Pain Relevance 0.52

General Comments

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