INT72126

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 3.94
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal 3
margin 2
muscle 2
respiratory 2
neurons 1
HIST2H2AA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 159 90.32 High High
butorphanol 3 88.64 High High
cytokine 44 87.76 High High
antagonist 72 86.88 High High
substance P 108 86.20 High High
chemokine 36 83.68 Quite High
anesthesia 13 83.40 Quite High
calcitonin gene related peptide 64 83.04 Quite High
qutenza 24 81.32 Quite High
agonist 8 80.92 Quite High
Disease Link Frequency Relevance Heat
Esophageal Disease 88 99.60 Very High Very High Very High
Drug Induced Neurotoxicity 9 97.92 Very High Very High Very High
Injury 40 95.28 Very High Very High Very High
Amyloid Plaque 105 91.76 High High
INFLAMMATION 203 90.32 High High
Alzheimer's Dementia 108 90.16 High High
Adult Respiratory Distress Syndrome 103 89.36 High High
Death 19 88.36 High High
Stress 55 86.80 High High
Pain 8 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant elevation of the cardiac pulse (mean = 0.7 cm H2O) and the respiratory pulse (mean = 1.1 cm H2O) that was consistent with raised cerebrospinal fluid pressure.
Positive_regulation (elevation) of H2O in respiratory
1) Confidence 0.38 Published 1997 Journal Neurosurgery Section Body Doc Link 9361064 Disease Relevance 0 Pain Relevance 0
There was a significant elevation of the cardiac pulse (mean = 0.7 cm H2O) and the respiratory pulse (mean = 1.1 cm H2O) that was consistent with raised cerebrospinal fluid pressure.
Positive_regulation (elevation) of H2O in respiratory
2) Confidence 0.38 Published 1997 Journal Neurosurgery Section Body Doc Link 9361064 Disease Relevance 0 Pain Relevance 0
However, the volume of air required to reach 50 cm H2O is only 150% of that required for safe ETTc pressure, suggesting that the margin for error in overinflation is not large.



Positive_regulation (reach) of H2O in margin
3) Confidence 0.25 Published 2009 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2729210 Disease Relevance 0 Pain Relevance 0
It should be noted, however, that the volume of air required to reach 50 cm H2O is only 150% of that required for safe ETTc pressure, suggesting that the margin for error in over inflation is not large.


Positive_regulation (reach) of H2O in margin
4) Confidence 0.25 Published 2009 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2729210 Disease Relevance 0.22 Pain Relevance 0.16
The peak inspiratory pressure in dorsal recumbency while still horizontal was 25 cm H2O (16-28 cm H2O), which increased to 29 cm H2O (18-46 cm H2O) after tilting (P = 0.02).
Positive_regulation (increased) of H2O in dorsal
5) Confidence 0.17 Published 2005 Journal J. Zoo Wildl. Med. Section Abstract Doc Link 17312721 Disease Relevance 0 Pain Relevance 0.15
The peak inspiratory pressure in dorsal recumbency while still horizontal was 25 cm H2O (16-28 cm H2O), which increased to 29 cm H2O (18-46 cm H2O) after tilting (P = 0.02).
Positive_regulation (increased) of H2O in dorsal
6) Confidence 0.17 Published 2005 Journal J. Zoo Wildl. Med. Section Abstract Doc Link 17312721 Disease Relevance 0 Pain Relevance 0.15
The peak inspiratory pressure in dorsal recumbency while still horizontal was 25 cm H2O (16-28 cm H2O), which increased to 29 cm H2O (18-46 cm H2O) after tilting (P = 0.02).
Positive_regulation (increased) of H2O in dorsal
7) Confidence 0.17 Published 2005 Journal J. Zoo Wildl. Med. Section Abstract Doc Link 17312721 Disease Relevance 0 Pain Relevance 0.16
During eSigh, VT was decreased to 390 ± 101 mL, Pplat increased from 31 ± 4 to 37 ± 2 cm H2O, and peak inspiratory pressure (Pmax) increased from 39 ± 6 to 47 ± 6 cm H2O.
Positive_regulation (increased) of H2O
8) Confidence 0.13 Published 2008 Journal Crit Care Section Body Doc Link PMC2447604 Disease Relevance 0.09 Pain Relevance 0
As previously described [17], our method of performing RM, eSigh, consisted of increasing PEEP 10 cm H2O above the LIP for 15 minutes, the patient being on volume-controlled ventilation (Figure 2b).
Positive_regulation (increasing) of H2O
9) Confidence 0.13 Published 2008 Journal Crit Care Section Body Doc Link PMC2447604 Disease Relevance 0.07 Pain Relevance 0
During eSigh, VT was decreased to 390 ± 101 mL, Pplat increased from 31 ± 4 to 37 ± 2 cm H2O, and peak inspiratory pressure (Pmax) increased from 39 ± 6 to 47 ± 6 cm H2O.
Positive_regulation (increased) of H2O
10) Confidence 0.13 Published 2008 Journal Crit Care Section Body Doc Link PMC2447604 Disease Relevance 0.09 Pain Relevance 0
In this study, we demonstrated that sevoflurane significantly increases intracellular H2O2 and/or peroxide, superoxide, and nitric oxide (NO) in PMN within 1h treatment.
Positive_regulation (increases) of H2O2 in PMN
11) Confidence 0.04 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16678324 Disease Relevance 0.30 Pain Relevance 0.12
Mean Paw was approximately 7.5 cm H2O at baseline and increased to 12.5 cm H2O after oleic acid, not different between groups at any time-period.
Positive_regulation (increased) of H2O in Paw
12) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1200564 Disease Relevance 0 Pain Relevance 0
After incubation with H2O2 for 15 min, the cells were harvested, and JNK activation was analyzed by immunoblotting with anti-phospho-JNK antibody.
Positive_regulation (activation) of H2O2
13) Confidence 0.01 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.07 Pain Relevance 0
H2O2 induced ?
Positive_regulation (induced) of H2O2
14) Confidence 0.01 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.19 Pain Relevance 0
can trigger the production of ROS and increase H2O2 accumulation in a Cu+/Fe2+-dependent manner, thereby damaging vulnerable neurons (14).
Positive_regulation (accumulation) of H2O2 in neurons
15) Confidence 0.01 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 1.02 Pain Relevance 0.04
H2O2 levels, taken as measure of PBL activation, increased when PBL are exposed to sac supernatant at pH 5 (Fig. 15).
Positive_regulation (increased) of H2O2
16) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.23 Pain Relevance 0.60
Basal H2O2 levels were elevated in circular muscle of esophagitis LES, exceeding normal levels by more than 2 standard deviations.
Positive_regulation (elevated) of H2O2 in muscle associated with esophageal disease
17) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.00 Pain Relevance 0.15
H2O2 levels, taken as measure of PBL activation, increased when PBL are exposed to sac supernatant at pH 5 (Fig. 15).
Positive_regulation (activation) of H2O2
18) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.22 Pain Relevance 0.59
Among these, NADPH oxidase 5 cDNA is significantly up-regulated by exposure to PAF; H2O2 content of esophageal and lower esophageal sphincter circular muscle is elevated in human esophagitis, causing dysfunction of esophageal circular muscle contraction and reduction in esophageal sphincter tone.
Positive_regulation (elevated) of H2O2 in muscle associated with esophageal disease
19) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Abstract Doc Link PMC2978390 Disease Relevance 0.44 Pain Relevance 0.78

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox