INT72129

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 4.61
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
sella 2
liver 2
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 6 100.00 Very High Very High Very High
opioid receptor 3 99.98 Very High Very High Very High
cytokine 15 85.36 High High
antagonist 3 85.32 High High
Inflammation 65 84.96 Quite High
Somatostatin 12 83.84 Quite High
Enkephalin 1 76.08 Quite High
MU agonist 1 75.00 Quite High
agonist 1 74.32 Quite High
tolerance 17 57.12 Quite High
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 11 99.28 Very High Very High Very High
Empty Sella Syndrome 1 99.02 Very High Very High Very High
Obesity 49 98.80 Very High Very High Very High
Frailty 31 98.66 Very High Very High Very High
Syndrome 23 97.60 Very High Very High Very High
Laron Syndrome 30 96.72 Very High Very High Very High
Growth Problems 18 95.68 Very High Very High Very High
Thalassemia 10 94.92 High High
Aging 88 94.76 High High
Osteoporosis 21 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacokinetic studies demonstrated a comparable concentration for circulating IGF-1 with twice a day rhIGF1 injections of 80 ?
Positive_regulation (concentration) of Positive_regulation (circulating) of IGF-1
1) Confidence 0.50 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0 Pain Relevance 0
Some authors debate that 0.033 mg/kg is too high a dose to identify mild GHI forms and suggested that a low-dose IGF-1 generation test (0.011 mg/kg of rhGH for four days) may be more useful in diagnosis of mild cases.22 However, a positive response to the test can be considered an increment of IGF-1 or IGFBP-3 more than twice the coefficient of variation of the assay used.23 The test identifies almost all the forms of primary GHI.


Positive_regulation (response) of Positive_regulation (increment) of IGF-1 associated with laron syndrome
2) Confidence 0.50 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.40 Pain Relevance 0.03
g/ml) partially restored IGF-1 production (P < 0.01) but interestingly the combination fully restored IGF-1 levels to baseline, untreated values despite the continued presence of IL-1?.


Positive_regulation (restored) of Positive_regulation (restored) of IGF-1
3) Confidence 0.50 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.08 Pain Relevance 0.09
GH response to provocation and circulating IGF-I and IGF-binding protein-3 concentrations, the IGF-I generation test and clinical response to GH therapy in children with beta-thalassaemia.
Positive_regulation (response) of Positive_regulation (circulating) of IGF-I associated with thalassemia
4) Confidence 0.47 Published 1998 Journal Eur. J. Endocrinol. Section Title Doc Link 9578506 Disease Relevance 0.61 Pain Relevance 0.16
Thus, higher levels of IGF-1 and IGFSD at baseline for all patients and higher levels of IGF-1 and IGFSD at 12 months for the NoP-group were associated with better BMD at both skeletal sites.
Positive_regulation (levels) of Positive_regulation (levels) of IGF-1
5) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0 Pain Relevance 0
A possible explanation for this unexpected increase in IGF-1 could be that glucocorticoids inhibit the production of IGF-1 in the muscle, followed by a decrease in negative feedback regulation of liver IGF-1, which would increase serum levels of IGF-1 [46].
Spec (possible) Positive_regulation (explanation) of Positive_regulation (increase) of IGF-1 in liver
6) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.23 Pain Relevance 0
Despite the presence of empty sella in all of the patients, they had an adequate GH response to clonidine provocation (peak, 19.3+/-5.8 microg/L) and a normal serum IGF-I concentration (309+/-142 ng/mL) for their age.
Positive_regulation (response) of Positive_regulation (concentration) of serum IGF-I in sella associated with empty sella syndrome and clonidine
7) Confidence 0.36 Published 1998 Journal Metab. Clin. Exp. Section Abstract Doc Link 9826209 Disease Relevance 0.41 Pain Relevance 0.16
A single injection of GH produced a smaller increase in circulating IGF-I in children with SCD with or without defective GH secretion versus 10 age-matched children with idiopathic short stature (ISS) and 11 children with isolated GH deficiency (GHD), suggesting partial GH resistance in the SCD group.
Positive_regulation (increase) of Positive_regulation (increase) of IGF-I associated with sickle cell anemia and growth problems
8) Confidence 0.17 Published 1997 Journal Metab. Clin. Exp. Section Abstract Doc Link 9361679 Disease Relevance 1.00 Pain Relevance 0.07
These studies concluded that despite atrophy and ultrastructural damage, elders respond to RT with significant increases in musculoskeletal remodeling, cross-sectional area and elevated IGF-I levels [99, 127].
Positive_regulation (increases) of Positive_regulation (elevated) of IGF-I associated with frailty
9) Confidence 0.10 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.24 Pain Relevance 0
Furthermore, MOPr-induced activation of IGF-I receptor requires the tyrosine kinase c-Src.
Positive_regulation (induced) of Positive_regulation (activation) of IGF-I associated with opioid receptor
10) Confidence 0.08 Published 2010 Journal FEBS Lett. Section Abstract Doc Link 20643133 Disease Relevance 0.15 Pain Relevance 0.31
It is suggested that increasing the circulating IGF-I concentration through aggressive nutritional therapy and/or GH/IGF-I therapy with supplementation with vitamin D and/or calcium might improve bone growth and mineralization and prevent the development of osteoporosis and consequent fractures in these patients.
Spec (might) Positive_regulation (increasing) of Spec (might) Positive_regulation (increasing) of IGF-I associated with osteoporosis
11) Confidence 0.08 Published 1998 Journal Metab. Clin. Exp. Section Abstract Doc Link 9591744 Disease Relevance 0.87 Pain Relevance 0.11
Once daily GHRH injections can stimulate increases in GH and IGF-I at least to the lower part of the young adult normal range (Merriam et al 2000).
Positive_regulation (stimulate) of Positive_regulation (increases) of IGF-I
12) Confidence 0.05 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.21 Pain Relevance 0.04
Bowers and colleagues showed that chronic repeated injections or subcutaneous infusions of GH-releasing peptide-2 (GHRP-2) could stimulate and maintain increases in episodic GH secretion and IGF-I (Bowers et al 2004).
Positive_regulation (stimulate) of Positive_regulation (increases) of IGF-I
13) Confidence 0.04 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.41 Pain Relevance 0.08

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