INT72137

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 6.45
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pthlh) Golgi apparatus (Pthlh) nucleus (Pthlh)
intracellular (Pthlh) cytoplasm (Pthlh)
Anatomy Link Frequency
osteoblasts 4
Pthlh (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 59.20 Quite High
Disease Link Frequency Relevance Heat
Cancer 48 100.00 Very High Very High Very High
Breast Cancer 12 100.00 Very High Very High Very High
Prostate Cancer 12 99.56 Very High Very High Very High
Metastasis 24 98.74 Very High Very High Very High
Pain 6 59.20 Quite High
Hypercalcemia 6 57.60 Quite High
Apoptosis 6 26.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of breast carcinoma, the final step in bone metastasis (namely bone destruction) is mediated by osteoclasts that are stimulated by local production of the tumor peptide parathyroid hormone-related peptide (PTH-rP), whereas prostate carcinomas stimulate osteoblasts to make new bone.
Positive_regulation (stimulated) of Gene_expression (production) of parathyroid hormone-related peptide in osteoblasts associated with cancer, breast cancer, prostate cancer and metastasis
1) Confidence 0.49 Published 1997 Journal Cancer Section Abstract Doc Link 9362421 Disease Relevance 1.04 Pain Relevance 0
Thus, a vicious cycle exists in bone between production by the tumor cells of mediators such as PTH-rP and subsequent production by bone of growth factors such as TGF-beta, which enhance PTH-rP production.
Positive_regulation (enhance) of Gene_expression (production) of PTH-rP associated with cancer
2) Confidence 0.49 Published 1997 Journal Cancer Section Abstract Doc Link 9362421 Disease Relevance 1.16 Pain Relevance 0.06
Production of PTH-rP by breast carcinoma cells in bone is enhanced by growth factors produced as a consequence of normal bone remodeling, particularly activated transforming growth factor-beta (TGF-beta).
Positive_regulation (enhanced) of Gene_expression (Production) of PTH-rP associated with breast cancer
3) Confidence 0.49 Published 1997 Journal Cancer Section Abstract Doc Link 9362421 Disease Relevance 1.02 Pain Relevance 0
Thus, a vicious cycle exists in bone between production by the tumor cells of mediators such as PTH-rP and subsequent production by bone of growth factors such as TGF-beta, which enhance PTH-rP production.
Positive_regulation (enhance) of Gene_expression (production) of PTH-rP associated with cancer
4) Confidence 0.49 Published 1997 Journal Cancer Section Abstract Doc Link 9362421 Disease Relevance 1.16 Pain Relevance 0.06
In the case of breast carcinoma, the final step in bone metastasis (namely bone destruction) is mediated by osteoclasts that are stimulated by local production of the tumor peptide parathyroid hormone-related peptide (PTH-rP), whereas prostate carcinomas stimulate osteoblasts to make new bone.
Positive_regulation (stimulated) of Gene_expression (production) of PTH-rP in osteoblasts associated with cancer, breast cancer, prostate cancer and metastasis
5) Confidence 0.49 Published 1997 Journal Cancer Section Abstract Doc Link 9362421 Disease Relevance 1.04 Pain Relevance 0
Production of PTH-rP by breast carcinoma cells in bone is enhanced by growth factors produced as a consequence of normal bone remodeling, particularly activated transforming growth factor-beta (TGF-beta).
Positive_regulation (enhanced) of Gene_expression (Production) of PTH-rP associated with breast cancer
6) Confidence 0.49 Published 1997 Journal Cancer Section Abstract Doc Link 9362421 Disease Relevance 1.02 Pain Relevance 0

General Comments

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