INT72141

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 10.91
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
coronary artery 2
macrophages 1
endothelial cells 1
plaque 1
Apoe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 37 99.44 Very High Very High Very High
epidural 2 93.16 High High
analgesia 8 92.00 High High
Shingles 6 91.52 High High
Post herpetic neuralgia 7 90.80 High High
Morphine 5 85.60 High High
cINOD 1 84.72 Quite High
Analgesic 16 75.84 Quite High
Pain 6 67.16 Quite High
gABA 8 55.44 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 24 100.00 Very High Very High Very High
Dementia 4 100.00 Very High Very High Very High
Coronary Artery Disease 27 99.76 Very High Very High Very High
Cv General 3 Under Development 35 99.44 Very High Very High Very High
Down Syndrome 1 99.44 Very High Very High Very High
Disease 13 99.30 Very High Very High Very High
Delirium 148 98.88 Very High Very High Very High
Genetic Predisposition To Disease 1 98.56 Very High Very High Very High
Herpes Zoster 10 97.06 Very High Very High Very High
Acute Coronary Syndrome 3 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only four risk factors for Alzheimer's disease can be regarded as confirmed--old age, family history of dementia, apo-E genotype and Down syndrome.
apo-E Binding (age) of associated with down syndrome, dementia and disease
1) Confidence 0.37 Published 1997 Journal Med. J. Aust. Section Abstract Doc Link 9364167 Disease Relevance 0.55 Pain Relevance 0.08
We suggest that the apoE genotype could be associated with acute coronary events in CAD and further study with in situ biochemical methods will be needed on the effects of apoE polymorphism on plaque stability.
apoE Binding (associated) of in plaque associated with coronary artery disease
2) Confidence 0.35 Published 1999 Journal Yonsei Med. J. Section Abstract Doc Link 10487142 Disease Relevance 1.35 Pain Relevance 0.18
Our rationale for the previous studies and for investigating VZV was that these micro-organisms use for cell binding and entry the same sites in the cell surface as does the protein apoE, and that consequently, competition with apoE could affect the pathogen's extent of entry and hence extent of the damage caused.
apoE Binding (competition) of associated with herpes zoster
3) Confidence 0.28 Published 2007 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 17356546 Disease Relevance 2.21 Pain Relevance 0.79
This is the case for the gene Apoe which is represented by two probe sets that both appear in the list of the 50 most DE genes in Table 1.
Apoe Binding (represented) of
4) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566599 Disease Relevance 0 Pain Relevance 0.03
It has been suggested that people with the epsilon4 allele of the apolipoprotein E (apoE) polymorphism and the deletion (D) allele of the insertion (I/D) polymorphism of angiotensin-converting enzymes, are at a greater risk for coronary artery disease.
apoE Binding (people) of in coronary artery associated with coronary artery disease and disorder of lipid metabolism
5) Confidence 0.16 Published 2001 Journal Can J Cardiol Section Abstract Doc Link 11420577 Disease Relevance 0.83 Pain Relevance 0.36
It has been suggested that people with the epsilon4 allele of the apolipoprotein E (apoE) polymorphism and the deletion (D) allele of the insertion (I/D) polymorphism of angiotensin-converting enzymes, are at a greater risk for coronary artery disease.
apolipoprotein E Binding (people) of in coronary artery associated with coronary artery disease and disorder of lipid metabolism
6) Confidence 0.16 Published 2001 Journal Can J Cardiol Section Abstract Doc Link 11420577 Disease Relevance 0.83 Pain Relevance 0.36
The ApoE polymorphism may be associated with IHD and VSA, probably due to the modulation of lipid metabolism.
ApoE Binding (associated) of associated with angina and coronary artery disease
7) Confidence 0.16 Published 2001 Journal Can J Cardiol Section Abstract Doc Link 11420577 Disease Relevance 1.42 Pain Relevance 0.85
Apo E on RLP serves as a ligand for uptake of RLP by macrophages, endothelial cells and other cells expressing the LDL receptor or the remnant receptor; uptake of RLP by vascular wall cells can promote atherosclerosis.
Apo E Binding (ligand) of in macrophages associated with atherosclerosis
8) Confidence 0.04 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9712343 Disease Relevance 0.67 Pain Relevance 0.06
They reported preferential adsorbtion of apolipoprotein E and apolipoprotein A-I in the in vitro studies, thereby suggesting the RME transport of chelators and chelator-metal complexes by the NPs across the BBB.
apolipoprotein E Binding (adsorbtion) of associated with disorder of lipid metabolism
9) Confidence 0.02 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.52 Pain Relevance 0.03
Apo E on RLP serves as a ligand for uptake of RLP by macrophages, endothelial cells and other cells expressing the LDL receptor or the remnant receptor; uptake of RLP by vascular wall cells can promote atherosclerosis.
Apo E Binding (ligand) of in endothelial cells associated with atherosclerosis
10) Confidence 0.01 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9712343 Disease Relevance 0.67 Pain Relevance 0.06
In the only study to date to examine whether there is a genetic predisposition to ICU delirium in some patients, Ely and coworkers [38] evaluated the association between apolipoprotein E (APOE) genotype and duration of delirium among 53 mechanically ventilated medical ICU patients.
apolipoprotein E Binding (association) of associated with delirium, genetic predisposition to disease and disorder of lipid metabolism
11) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2391269 Disease Relevance 1.86 Pain Relevance 0.46

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