INT72147

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.64
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Cttn) cytoplasm (Cttn)
Anatomy Link Frequency
mast cells 1
Cttn (Mus musculus)
Pain Link Frequency Relevance Heat
MU agonist 4 98.96 Very High Very High Very High
Enkephalin 2 98.54 Very High Very High Very High
Opioid 4 91.12 High High
opioid receptor 6 85.20 High High
Kinase C 2 80.92 Quite High
Central nervous system 2 67.60 Quite High
dorsal root ganglion 37 43.48 Quite Low
withdrawal 1 5.00 Very Low Very Low Very Low
Root ganglion neuron 1 5.00 Very Low Very Low Very Low
nociceptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 7 93.84 High High
Shock 22 86.40 High High
Ganglion Cysts 38 50.00 Quite Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Wallerian Degeneration 1 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is also evidence that Fyn might regulate Fps, and possibly Fer, as Fyn has been shown to phosphorylate a kinase-defective mutant form of Fps in Sf-9 cells [45], Fer and Fyn cooperate in actin depolymerization-induced cortactin phosphorylation [26], and the Fyn-related Lyn kinase regulates Fer phosphorylation in mast cells downstream of the IgE receptor engagement [46].
Phosphorylation (phosphorylation) of cortactin in mast cells
1) Confidence 0.28 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.14 Pain Relevance 0
Tyrosine phosphorylation of cortactin led to drastic changes in subcellular localization, an estimated 2-fold enrichment in the cytosol.
Phosphorylation (phosphorylation) of cortactin
2) Confidence 0.06 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9364324 Disease Relevance 0.25 Pain Relevance 0.63
We also demonstrate that met-enkephalin, a mu-opioid agonist in E6CH cultures, significantly increases tyrosine phosphorylation of another Src kinase substrate, the cytoskeletal protein cortactin.
Phosphorylation (phosphorylation) of cortactin associated with mu agonist and enkephalin
3) Confidence 0.05 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9364324 Disease Relevance 0.25 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox