INT72149

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Context Info
Confidence 0.31
First Reported 1997
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.95
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Cttn) cytoplasm (Cttn)
Anatomy Link Frequency
platelet 2
embryonic neurons 1
Cttn (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 3 98.96 Very High Very High Very High
opioid receptor 4 95.40 Very High Very High Very High
Kinase C 1 93.24 High High
MU agonist 2 83.72 Quite High
Enkephalin 1 76.84 Quite High
antinociception 1 61.92 Quite High
Central nervous system 1 52.44 Quite High
agonist 12 11.28 Low Low
Analgesic 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cicatrix 12 100.00 Very High Very High Very High
Adhesions 7 99.76 Very High Very High Very High
Stress 2 86.08 High High
Thrombosis 10 13.36 Low Low
Hemorrhage 10 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Coagulation Disorder 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We probed western blots of platelet protein extracts for cortactin, WASp, Scar/WAVE1 and Scar\WAVE2 to determine if there was any up-regulation of these proteins.
Regulation (regulation) of cortactin in platelet associated with cicatrix
1) Confidence 0.31 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.51 Pain Relevance 0
Spread platelets were also immunostained for cortactin (Figure 2D) to establish whether a lack of HS1 altered the distribution of cortactin.
Spec (whether) Regulation (altered) of cortactin in platelets
2) Confidence 0.31 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.20 Pain Relevance 0
Our results indicate that the proper spatial disposition of the third aromatic ring plays an important role in the regulation of pharmacological activities of EMs.
Regulation (regulation) of EMs
3) Confidence 0.11 Published 2007 Journal Peptides Section Abstract Doc Link 17276550 Disease Relevance 0 Pain Relevance 0.17
mu-Opioids activate tyrosine kinase focal adhesion kinase and regulate cortical cytoskeleton proteins cortactin and vinculin in chick embryonic neurons.
Regulation (regulate) of cortactin in embryonic neurons associated with opioid and adhesions
4) Confidence 0.02 Published 1997 Journal J. Neurosci. Res. Section Title Doc Link 9364324 Disease Relevance 0.24 Pain Relevance 0.59

General Comments

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