INT72165

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.76
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL6) extracellular space (CXCL6) extracellular region (CXCL6)
cell-cell signaling (CXCL6)
Anatomy Link Frequency
lung 2
granulocyte 1
immune cells 1
placentas 1
CXCL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 120 100.00 Very High Very High Very High
Inflammation 100 100.00 Very High Very High Very High
cytokine 36 100.00 Very High Very High Very High
cINOD 9 75.00 Quite High
Osteoarthritis 1 63.68 Quite High
palliative 2 39.48 Quite Low
rheumatoid arthritis 34 25.44 Quite Low
Arthritis 29 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 113 100.00 Very High Very High Very High
Colon Cancer 126 99.62 Very High Very High Very High
Cancer 216 99.14 Very High Very High Very High
Hypoxia 31 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 40 98.72 Very High Very High Very High
Lung Cancer 4 98.52 Very High Very High Very High
Necrosis 5 87.12 High High
Pre-term Labor 2 76.72 Quite High
Rupture 1 74.40 Quite High
Metastasis 33 74.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The disparity in angiogenic activity among CXC chemokine family members is attributed to three amino acid structural domains at the N terminus, Glu-Leu-Arg (ELR), which is present in angiogenic (i.e., CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8) [4-6], but not angiostatic (i.e., CXCL4, CXCL9, CXCL10, and CXCL11) CXC chemokines [7].
Gene_expression (present) of CXCL6 associated with chemokine
1) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.71 Pain Relevance 0.27
Only CXCL-8/IL-8 and CXCL-6 specifically bind to CXCR1 whereas all ELR+CXC chemokines bind to CXCR2.
Gene_expression (/) of CXCL-6 associated with chemokine
2) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.67 Pain Relevance 0.33
CXCL6 also has angiogenesis activity and can stimulate cancer cell progression.26,27 Zhu et al reported overexpression of CXCL6 with its receptor, IL8R, in hypoxic small cell lung cancer, which is an autocrine regulation for cell progression.28 Rubie et al observed an overexpression of CXCL1 and CXCL5 in CRC, but the level of CXCL6 was not changed.29 Our observations showed that copy number loss and low expression levels were correlated with the invasiveness of CRC.
Gene_expression (overexpression) of CXCL6 in lung associated with lung cancer, hypoxia, cancer and colon cancer
3) Confidence 0.38 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 0.68 Pain Relevance 0.18
CXCL6 also has angiogenesis activity and can stimulate cancer cell progression.26,27 Zhu et al reported overexpression of CXCL6 with its receptor, IL8R, in hypoxic small cell lung cancer, which is an autocrine regulation for cell progression.28 Rubie et al observed an overexpression of CXCL1 and CXCL5 in CRC, but the level of CXCL6 was not changed.29 Our observations showed that copy number loss and low expression levels were correlated with the invasiveness of CRC.
Gene_expression (expression) of CXCL6 in lung associated with lung cancer, hypoxia, cancer and colon cancer
4) Confidence 0.30 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 0.69 Pain Relevance 0.15
Membranes from preterm delivered placentas show higher levels of chemotactic proteins MCP-1 and CXCL6 (Granulocyte chemotactic protein-2), inflammatory cytokines IL-1?
Gene_expression (levels) of CXCL6 in placentas associated with inflammation and cytokine
5) Confidence 0.28 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 1.01 Pain Relevance 0.13
/CXCL1, connective tissue-activating peptide-III (CTAP-III)/CXCL7, granulocyte chemotactic protein-2/CXCL6, IP-10/CXCL10, PF4/CXCL4, monokine induced by IFN-?
Gene_expression (/) of CXCL6 in granulocyte
6) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.38 Pain Relevance 0.65
Arterial SMCs, in particular, express a large set of genes that mediate these interactions—such as cytokines/chemokines (IL6, CCL8, CCL7, CCL2, CXCL1, CXCL2, CXCL3, and CXCL6), complement pathway (complement factor B [CFB]), and surface receptor (ICAM1) (Figure 3B)—suggesting that vascular SMCs may themselves mediate recruitment of immune cells to the vascular walls.
Gene_expression (express) of CXCL6 in immune cells associated with chemokine and cytokine
7) Confidence 0.20 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.17 Pain Relevance 0.10
Production of the part anti-inflammatory cytokine IL-6, was significantly increased by therapeutic concentrations of meloxicam, as well as by indomethacin.
Gene_expression (Production) of cytokine IL-6 associated with inflammation and cytokine
8) Confidence 0.13 Published 1997 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9364409 Disease Relevance 0.47 Pain Relevance 0.78

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