INT72166

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Context Info
Confidence 0.24
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 10.23
Pain Relevance 7.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (RETNLB) extracellular region (RETNLB) molecular_function (RETNLB)
cellular_component (RETNLB)
Anatomy Link Frequency
macrophages 2
muscle 2
cartilage 2
brain 2
regulatory T lymphocytes 2
RETNLB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 113 100.00 Very High Very High Very High
cytokine 85 100.00 Very High Very High Very High
chemokine 3 100.00 Very High Very High Very High
Inflammatory mediators 2 100.00 Very High Very High Very High
Osteoarthritis 13 99.92 Very High Very High Very High
opiate 10 99.38 Very High Very High Very High
spinal inflammation 2 99.34 Very High Very High Very High
cINOD 23 98.98 Very High Very High Very High
ischemia 11 97.04 Very High Very High Very High
aspirin 11 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 127 100.00 Very High Very High Very High
Adhesions 2 100.00 Very High Very High Very High
Hyperglycemia 10 99.98 Very High Very High Very High
Osteoarthritis 1 99.92 Very High Very High Very High
Low Back Pain 2 99.34 Very High Very High Very High
Frailty 28 98.76 Very High Very High Very High
Cv Unclassified Under Development 9 97.04 Very High Very High Very High
Infection 8 96.68 Very High Very High Very High
Middle Cerebral Artery Infarction 1 95.28 Very High Very High Very High
Recurrence 8 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although proliferation of lymphocytes tested in vitro after application of opiates in vivo is generally reduced, production of the pro-inflammatory cytokines and some functions of macrophages can be enhanced.
Positive_regulation (enhanced) of Gene_expression (production) of pro-inflammatory in macrophages associated with inflammation, opiate and cytokine
1) Confidence 0.24 Published 2003 Journal Cas. Lek. Cesk. Section Abstract Doc Link 12841129 Disease Relevance 0.41 Pain Relevance 1.23
Prior PC significantly reduced the post-ischemic increased expression of many inflammatory genes including cytokines, chemokines, adhesion molecules and pro-inflammatory transcription factors, and prevented the infiltration of neutrophils and macrophages in the ipsilateral cortex of rats subjected to focal ischemia.
Positive_regulation (increased) of Gene_expression (expression) of pro-inflammatory in cortex associated with chemokine, inflammation, ischemia, adhesions and cytokine
2) Confidence 0.22 Published 2006 Journal Neurochem. Int. Section Abstract Doc Link 16759752 Disease Relevance 1.25 Pain Relevance 0.74
In contrast, low-to-moderate doses induced a modestly enhanced production of pro-inflammatory cytokines.
Positive_regulation (induced) of Gene_expression (production) of pro-inflammatory associated with inflammation and cytokine
3) Confidence 0.04 Published 2004 Journal Scand. J. Immunol. Section Abstract Doc Link 15379866 Disease Relevance 0.82 Pain Relevance 0.87
In contrast, low-to-moderate doses induced a modestly enhanced production of pro-inflammatory cytokines.
Positive_regulation (enhanced) of Gene_expression (production) of pro-inflammatory associated with inflammation and cytokine
4) Confidence 0.04 Published 2004 Journal Scand. J. Immunol. Section Abstract Doc Link 15379866 Disease Relevance 0.82 Pain Relevance 0.87
Some non-steroidal anti-inflammatory drugs (NSAIDs) can accelerate joint damage in osteoarthritis by enhancing the production of pro-inflammatory cytokines or inhibiting cartilage proteoglycan synthesis.
Positive_regulation (enhancing) of Gene_expression (production) of pro-inflammatory in cartilage associated with inflammation, cinod, osteoarthritis and cytokine
5) Confidence 0.02 Published 1997 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9364409 Disease Relevance 0.36 Pain Relevance 0.67
It is clear from this study that HA preparations can induce the synthesis of pro-inflammatory cytokines by monocytes.
Positive_regulation (induce) of Gene_expression (synthesis) of pro-inflammatory in monocytes associated with inflammation and cytokine
6) Confidence 0.02 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.58 Pain Relevance 0.40
Our results are in conflict with several other studies showing that hyperglycemia increases the production of pro-inflammatory cytokines [21,22].
Positive_regulation (increases) of Gene_expression (production) of pro-inflammatory associated with hyperglycemia, inflammation and cytokine
7) Confidence 0.01 Published 2005 Journal Crit Care Section Body Doc Link PMC1414017 Disease Relevance 0.94 Pain Relevance 0.41
As the immune response evolves, the increase in the production of pro-inflammatory cytokines such as IFNs stimulates the secretion of IDO by pDCs, which in turn will activate regulatory T lymphocytes.
Positive_regulation (increase) of Gene_expression (production) of pro-inflammatory in regulatory T lymphocytes associated with inflammation and cytokine
8) Confidence 0.01 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 0.84 Pain Relevance 0.36
Frailty and disability in older adult muscle is also associated with increased production of systemic pro-inflammatory cytokines [72], [73].
Positive_regulation (increased) of Gene_expression (production) of pro-inflammatory in muscle associated with inflammation, frailty and cytokine
9) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 1.21 Pain Relevance 0.34
Bacterial colonization and/or inflammation of the choriodecidual interface induces production of pro-inflammatory cytokines that, in turn, lead to neutrophil activation and the synthesis and release of uterotonins such as prostaglandins (which cause uterine contractions) and metalloproteinases (that weaken fetal membranes and remodel cervical collagen).
Positive_regulation (induces) of Gene_expression (production) of pro-inflammatory in uterine associated with inflammation, metalloproteinase, dismenorea and cytokine
10) Confidence 0.00 Published 2005 Journal Minerva Ginecol Section Abstract Doc Link 16170281 Disease Relevance 1.38 Pain Relevance 0.50
The association suggests that increased production of pro-inflammatory cytokines in the brain may be an underlying mechanism for neural damage induced by the chronic sodium salicylate treatment.
Positive_regulation (increased) of Gene_expression (production) of pro-inflammatory in brain associated with inflammation and cytokine
11) Confidence 0.00 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683422 Disease Relevance 0.53 Pain Relevance 0.44
Metabolism of omega-6 (n-6) PUFAs results in the production of pro-inflammatory mediators whereas downstream products of omega-3 (n-3) PUFAs have lower inflammatory activity.
Positive_regulation (results) of Gene_expression (production) of pro-inflammatory associated with inflammatory mediators and inflammation
12) Confidence 0.00 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 17277229 Disease Relevance 0.75 Pain Relevance 0.14
OBJECTIVES: This study was performed to investigate whether leptin mRNA expression is increased from peripheral blood mononuclear cells (PBMCs) of patients with active ankylosing spondylitis (AS) and whether it stimulates the production of pro-inflammatory cytokines.
Positive_regulation (stimulates) of Gene_expression (production) of pro-inflammatory in mononuclear cells associated with spinal inflammation, inflammation and cytokine
13) Confidence 0.00 Published 2009 Journal Joint Bone Spine Section Abstract Doc Link 19059800 Disease Relevance 0.35 Pain Relevance 0.31
These findings were in marked contrast to the IBD patients who demonstrated increased production of both chemokines and pro-inflammatory cytokines.
Positive_regulation (increased) of Gene_expression (production) of pro-inflammatory
14) Confidence 0.00 Published 2008 Journal Scand. J. Gastroenterol. Section Body Doc Link 18752146 Disease Relevance 0 Pain Relevance 0

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