INT72167

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Context Info
Confidence 0.05
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 4.39
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (RETNLB) extracellular region (RETNLB) molecular_function (RETNLB)
cellular_component (RETNLB)
Anatomy Link Frequency
chondrocytes 2
dental pulp 2
PGE2 2
RETNLB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 190 100.00 Very High Very High Very High
cytokine 37 99.96 Very High Very High Very High
Arthritis 3 98.52 Very High Very High Very High
Inflammatory response 114 97.40 Very High Very High Very High
Pain 14 93.60 High High
cINOD 11 85.28 High High
tolerance 2 80.12 Quite High
Osteoarthritis 5 78.72 Quite High
Inflammatory stimuli 70 63.20 Quite High
corticosteroid 112 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 325 100.00 Very High Very High Very High
Adhesions 3 99.40 Very High Very High Very High
Arthritis 3 98.52 Very High Very High Very High
Pain 13 93.60 High High
Asthma 1 88.24 High High
Knee Osteoarthritis 3 79.96 Quite High
Osteoarthritis 2 78.72 Quite High
Hyperalgesia 1 25.00 Low Low
Disease 12 9.36 Low Low
Systemic Inflammatory Response Syndrome 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence suggests that exposure to bacterial endotoxin in early life can alter the production of pro-inflammatory cytokines in later life.
Regulation (alter) of Gene_expression (production) of pro-inflammatory associated with inflammation and cytokine
1) Confidence 0.05 Published 2010 Journal Physiol. Behav. Section Abstract Doc Link 20184906 Disease Relevance 0.68 Pain Relevance 0.68
Meloxicam at submicromolar concentrations inhibited synovial PGE2 production but, up to therapeutic drug concentrations (< or = 4 microM), did not affect synovial production of the pro-inflammatory cytokine IL-1.
Neg (not) Regulation (affect) of Gene_expression (production) of pro-inflammatory in PGE2 associated with inflammation and cytokine
2) Confidence 0.01 Published 1997 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9364409 Disease Relevance 0.47 Pain Relevance 0.79
In this study, we investigated the effect of epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), the major components of green tea catechins, on the expression of pro-inflammatory cytokines and adhesion molecules in human dental pulp cells stimulated with bacteria-derived factors such as lipopolysaccharide (LPS) and peptidoglycan (PG).
Spec (investigated) Regulation (effect) of Gene_expression (expression) of pro-inflammatory in dental pulp associated with inflammation, adhesions and cytokine
3) Confidence 0.01 Published 2010 Journal Eur. J. Oral Sci. Section Abstract Doc Link 20487003 Disease Relevance 0.60 Pain Relevance 0.23
We also employed cultured chondrocytes from different OA patients to examine NSAID effects on pro-inflammatory gene expression in cells stimulated with interleukin (IL)-1beta.
Spec (examine) Regulation (effects) of Gene_expression (expression) of pro-inflammatory in chondrocytes
4) Confidence 0.01 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 18547825 Disease Relevance 0.31 Pain Relevance 0
As such, DR* is the signal activating, i.e., transcriptionally regulating, the expression of the pro-inflammatory genes.
Regulation (regulating) of Gene_expression (expression) of pro-inflammatory associated with inflammation
5) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.95 Pain Relevance 0.52
Therefore, we introduce the NFkB signal transduction cascade as the prototypical module for initiating and controlling the expression of pro-inflammatory genes.
Regulation (controlling) of Gene_expression (expression) of pro-inflammatory associated with inflammation
6) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.65 Pain Relevance 0.32
A lipid extract of Perna canaliculus affects the expression of pro-inflammatory cytokines in a rat adjuvant-induced arthritis model.
Regulation (affects) of Gene_expression (expression) of pro-inflammatory associated with inflammation, arthritis and cytokine
7) Confidence 0.00 Published 2008 Journal Eur Ann Allergy Clin Immunol Section Title Doc Link 19227651 Disease Relevance 0.72 Pain Relevance 0.48

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