INT72182

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2011
Negated 3
Speculated 4
Reported most in Body
Documents 167
Total Number 171
Disease Relevance 123.70
Pain Relevance 52.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
macrophages 11
monocyte 7
astrocyte 6
retina 5
microglia 5
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3872 100.00 Very High Very High Very High
cytokine 1887 100.00 Very High Very High Very High
chemokine 757 100.00 Very High Very High Very High
metalloproteinase 309 100.00 Very High Very High Very High
Morphine 573 99.98 Very High Very High Very High
opioid receptor 137 99.96 Very High Very High Very High
Paracetamol 72 99.82 Very High Very High Very High
rheumatoid arthritis 299 99.76 Very High Very High Very High
agonist 392 99.72 Very High Very High Very High
qutenza 18 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4217 100.00 Very High Very High Very High
Cancer 522 100.00 Very High Very High Very High
Adhesions 493 100.00 Very High Very High Very High
Asthma 253 100.00 Very High Very High Very High
Necrosis 135 100.00 Very High Very High Very High
Pulmonary Disease 322 99.84 Very High Very High Very High
Sprains And Strains 265 99.82 Very High Very High Very High
Rheumatoid Arthritis 359 99.76 Very High Very High Very High
Obesity 86 99.68 Very High Very High Very High
Cv General 4 Under Development 8 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.
Gene_expression (expressions) of MCP-1 in adipocytes associated with qutenza and obesity
1) Confidence 0.75 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.22 Pain Relevance 0.66
However, the few asthma/inflammatory genes that are differentially expressed (Pik3cd, Arg1, Slc7a2, Ccl24, Mcpt1) are all up-regulated in ETS-exposed mice.
Gene_expression (expressed) of Mcpt1 associated with asthma, nicotine addiction and inflammation
2) Confidence 0.74 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.29 Pain Relevance 0.31
Consistent with the first experiment, there was a significant effect of mechanical ventilation on lung levels of KC/CXCL1, MCP1/CCL2, MIP1?
Gene_expression (/) of MCP1 in lung
3) Confidence 0.65 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.38 Pain Relevance 0.22
We found that hepatic expression of CCR2 and MCP-1 was increased 10-fold and 20-fold, respectively, 12 to 72 hours after administration of acetaminophen to wild-type mice.
Gene_expression (expression) of MCP-1 associated with paracetamol
4) Confidence 0.60 Published 2002 Journal Hepatology Section Abstract Doc Link 11981759 Disease Relevance 0.44 Pain Relevance 0.51
Whereas MCP-1 was expressed by both hepatocytes and macrophages, CCR2 was identified in inflammatory macrophages.
Gene_expression (expressed) of MCP-1 in macrophages associated with inflammation
5) Confidence 0.60 Published 2002 Journal Hepatology Section Abstract Doc Link 11981759 Disease Relevance 0.55 Pain Relevance 0.63
B (oxidant-induced transcription factors associated with inflammation) are found in the promoter region of the MCP-1 gene, and their cooperative action is important in the induction of MCP-1 gene expression (Martin et al. 1997).
Gene_expression (expression) of MCP-1 associated with inflammation
6) Confidence 0.60 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.50 Pain Relevance 0.07
Thus, attenuation of leukocyte recruitment by EPA may result in the decreased production levels of IL-6 and MCP-1 in the retina and choroid.
Gene_expression (production) of MCP-1 in retina
7) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.09 Pain Relevance 0.41
Overall, there were significant effects from both mechanical ventilation and genotype on expression of KC/CXCL1, MCP1/CCL2, MIP1?
Gene_expression (expression) of MCP1
8) Confidence 0.58 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.10 Pain Relevance 0.12
To clarify the status of these genes, the same RNA samples that had been subjected to the microarray assay underwent qRT-PCR to determine differential expression of 14 genes previously associated with asthma by other investigators (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Pde4b, Pde4d, Slc7a2, Tgfb1), as well as 7 cytokine genes associated with asthma and/or pulmonary inflammation (Ifn?
Spec (determine) Gene_expression (expression) of Mcpt1 associated with asthma, inflammation, pneumonia and cytokine
9) Confidence 0.57 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.38 Pain Relevance 0.14
Previous studies have revealed that MCP-1 is necessary for the activation of T lymphocytes (Taub et al. 1995) and that MCP-1 produced by lung fibroblasts exerts an immunomodulatory effect on CD4+ T cells in vitro (Hogaboam et al. 1998).
Gene_expression (produced) of MCP-1 in fibroblasts
10) Confidence 0.53 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.66 Pain Relevance 0.28
RESULTS AND CONCLUSIONS: Ginsenoside Rb1 (1 ng/wound) and basic fibroblast growth factor (bFGF) (2.5 microg/wound) significantly increased the levels of MCP-1 on day 1 compared to the MCP-1 level in vehicle-treated mice.
Gene_expression (levels) of MCP-1 in fibroblast
11) Confidence 0.53 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18329832 Disease Relevance 0.43 Pain Relevance 0
Similar to MCP-1, the level of IL-6 protein was also undetectable in the retinal tissue of control animals (n=6; Figure 3B).
Gene_expression (undetectable) of MCP-1
12) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.83 Pain Relevance 0.15
and MCP-1 transcript expression within the entorhinal cortex of 3xTg-AD mice indicates that a regional difference exists between the entorhinal cortex and hippocampus that would elaborate a time-dependent increase in the intensity of inflammatory processes.
Gene_expression (expression) of MCP-1 transcript in hippocampus associated with inflammation, hippocampus and disease
13) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.78 Pain Relevance 0.25
and MCP-1 expression prior to significant plaque deposition in 3xTg-AD mice, which occurs extensively at 12 months [19], may represent a contributory role between inflammatory processes and early AD pathogenesis.
Gene_expression (expression) of MCP-1 in plaque associated with inflammation and disease
14) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 1.19 Pain Relevance 0.49
Since changes were not observed in APP processing, the authors concluded that MCP-1 overexpression in APPswe mice correlated with diminished clearance of A?
Gene_expression (overexpression) of MCP-1
15) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.53 Pain Relevance 0.11
and MCP-1 expression
Gene_expression (expression) of MCP-1
16) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.67 Pain Relevance 0.24
and MCP-1 are produced specifically within the entorhinal cortex where human AD has been shown to arise, these molecules are likely playing an instrumental role in disease perpetuation.
Gene_expression (produced) of MCP-1 in cortex associated with disease
17) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.93 Pain Relevance 0.12
Strain differences in V2O5-induced inflammatory chemokine (KC, MIP-2, MCP-1) expression
Gene_expression (expression) of MCP-1 associated with chemokine, inflammation and sprains and strains
18) Confidence 0.49 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 1.19 Pain Relevance 0.33
It was previously documented that infiltrated leukocytes were the cellular source of IL-6 [34] and MCP-1 [38] in ocular tissues.
Gene_expression (source) of MCP-1 in leukocytes
19) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.10 Pain Relevance 0.43
In addition, EPA significantly reduced the protein levels of MCP-1 and IL-6 in the retina and the RPE-choroid complex.
Gene_expression (levels) of MCP-1 in retina
20) Confidence 0.46 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2905642 Disease Relevance 0.78 Pain Relevance 0.11

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