INT72188

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2009
Negated 0
Speculated 3
Reported most in Body
Documents 22
Total Number 28
Disease Relevance 12.93
Pain Relevance 15.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
neuronal 4
monocyte 3
macrophages 2
vessels 2
CSF 1
Cxcl10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 1422 100.00 Very High Very High Very High
Inflammation 564 100.00 Very High Very High Very High
Hyperalgesia 178 98.92 Very High Very High Very High
Chronic pancreatitis 3 98.64 Very High Very High Very High
qutenza 73 98.28 Very High Very High Very High
diclofenac 78 98.08 Very High Very High Very High
Endogenous opioid 9 95.92 Very High Very High Very High
intrathecal 4 95.12 Very High Very High Very High
cytokine 113 94.96 High High
Analgesic 22 94.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 690 100.00 Very High Very High Very High
Nervous System Injury 284 99.08 Very High Very High Very High
Hyperalgesia 365 98.92 Very High Very High Very High
Pancreatitis 3 98.64 Very High Very High Very High
Ganglion Cysts 177 94.00 High High
Demyelinating Disease 449 93.52 High High
Appendicitis 1 93.16 High High
Inflammatory Pain 131 92.72 High High
Pain 345 92.20 High High
Inflammatory Bowel Disease 1 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced protein 10 (IP-10/CXCL10), MCP1 and SDF1 were added to the cells in random order, after which capsaicin, high K+ (50 K) and ATP were added.
Gene_expression (added) of CXCL10 associated with qutenza
1) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.15 Pain Relevance 0.33
The signaling pattern of IP-10 and CXCR3 receptors in the DRG differs in some respects as there is appreciable basal neuronal expression of both CXCR3 receptors and IP-10.
Gene_expression (expression) of IP-10 in neuronal
2) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.58 Pain Relevance 0.80
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Gene_expression (expressed) of IP10 in vesicles associated with chemokine
3) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.29 Pain Relevance 0.55
In spite of this, few Ca2+ neuronal responses were observed in the naïve or sham animals, perhaps because of desensitization resulting from ongoing receptor activation induced by constitutive expression of IP-10.
Gene_expression (expression) of IP-10 in neuronal
4) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.62 Pain Relevance 0.74
Neuronal expression of IP-10/CXCR3 under basal conditions may have a specific role to play that is analogous to the expression and release of fractalkine by neurons [42,55].
Gene_expression (expression) of IP-10 in Neuronal
5) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.57 Pain Relevance 0.69
The signaling pattern of IP-10 and CXCR3 receptors in the DRG differs in some respects as there is appreciable basal neuronal expression of both CXCR3 receptors and IP-10.
Gene_expression (expression) of IP-10 in neuronal
6) Confidence 0.55 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.65 Pain Relevance 0.86
For all experiments, the chemokines MCP-1, SDF-1, RANTES and IP-10 were added in random order to the cells, after which capsaicin, high K+(50 mM) and ATP were added to assess the cells' identity and viability, respectively.
Gene_expression (added) of IP-10 associated with chemokine and qutenza
7) Confidence 0.55 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.13 Pain Relevance 0.67
For all experiments, MCP-1, SDF1, RANTES and IP10 were added to the cells in random order, after which capsaicin, high K+ (50 K) and ATP were added.
Gene_expression (added) of IP10 associated with qutenza
8) Confidence 0.55 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.09 Pain Relevance 0.27
The chemokine SDF-1/CXCL12 and its receptor CXCR4 are constitutively expressed by peripheral nerves [3,27-29] and chemokines that activate CCR5 and CXCR3 receptors, such as RANTES and IP-10, are synthesized in association with neuroinflammatory responses [16,30].
Gene_expression (synthesized) of IP-10 in peripheral nerves associated with chemokine
9) Confidence 0.55 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.38 Pain Relevance 0.57
The mean diameter of IP-10-immunopositive neurons in the vehicle-treated rat was 47.53 ± 1.7 ?
Gene_expression (neurons) of IP-10-immunopositive in neurons
10) Confidence 0.48 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.32 Pain Relevance 0.11
However, we also examined the expression of IP-10 and MCP-1, which recruit T cells and monocytes/macrophages, respectively, because such chemokines are released by mastocytes, macrophages and fibroblasts resident in the inflamed tissue.
Spec (examined) Gene_expression (expression) of IP-10 in macrophages associated with chemokine
11) Confidence 0.39 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.55 Pain Relevance 0.56
The expression of the pro-inflammatory chemokines interferon-gamma-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in the paws was assessed.
Gene_expression (expression) of interferon-gamma-inducible protein-10 in monocyte associated with chemokine and inflammation
12) Confidence 0.39 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.69 Pain Relevance 0.58
Carrageenan-treated rat paws expressed IL-8 and IP-10 on dermal infiltrating cells, whereas a low expression of IP-10 on dermal cells followed oATP treatment alone (both local and intravenous).
Gene_expression (expressed) of IP-10
13) Confidence 0.39 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.37 Pain Relevance 0.31
The levels of CXCL10 were higher in the patient group than in controls but two outliers in the control group also had high CSF concentrations of CXCL10.
Gene_expression (levels) of CXCL10 in CSF
14) Confidence 0.34 Published 2001 Journal Eur. J. Neurol. Section Abstract Doc Link 11784351 Disease Relevance 0.77 Pain Relevance 0.72
The expression of the pro-inflammatory chemokines interferon-gamma-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in the paws was assessed.
Gene_expression (expression) of IP-10 in monocyte associated with chemokine and inflammation
15) Confidence 0.34 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.69 Pain Relevance 0.58
Carrageenan-treated rat paws expressed IL-8 and IP-10 on dermal infiltrating cells, whereas a low expression of IP-10 on dermal cells followed oATP treatment alone (both local and intravenous).
Gene_expression (expression) of IP-10
16) Confidence 0.34 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.36 Pain Relevance 0.31
The three selected chemokines are described to be able to recruit the principal inflammatory cells: granulocytes (IL-8), monocytes/macrophages (MCP-1) and T lymphocytes (IP-10).
Gene_expression (granulocytes) of IP-10 in macrophages associated with chemokine and inflammation
17) Confidence 0.33 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.59 Pain Relevance 0.77
A low expression of IP-10 on papillary dermis cells was observed on hind paws from rats treated with oATP alone, following either local (Fig. 6e) or intravenous injection (Fig. 6f).
Gene_expression (expression) of IP-10 in dermis
18) Confidence 0.30 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.26 Pain Relevance 0.31
Following oATP treatment, the expression of the pro-inflammatory chemokines interferon-gamma-inducible protein-10 (IP-10), mon ocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) within the inflamed tissues markedly decreased on vessels and infiltrated cells.
Gene_expression (expression) of interferon-gamma-inducible protein-10 in vessels associated with chemokine and inflammation
19) Confidence 0.30 Published 2005 Journal BMC Immunol Section Abstract Doc Link PMC1190175 Disease Relevance 0.51 Pain Relevance 0.52
Conversely, carrageenan-treated rat hind paw section samples expressed both IL-8 and IP-10 on dermis infiltrating cells, but not on vessel walls (Fig. 6b).
Gene_expression (expressed) of IP-10 in paw
20) Confidence 0.30 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.28 Pain Relevance 0.29

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