INT72203

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Context Info
Confidence 0.10
First Reported 1997
Last Reported 1997
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.46

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nucleoplasm (OGG1) mitochondrion (OGG1) lyase activity (OGG1)
cytoplasm (OGG1) extracellular space (GH1) extracellular region (GH1)
Anatomy Link Frequency
plasma 2
GH1 (Homo sapiens)
OGG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 4 99.84 Very High Very High Very High
Clonidine 2 96.12 Very High Very High Very High
Intracerebroventricular 2 91.40 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bovine GH (at 50 micrograms or 500 micrograms) i.c.v. did not affect basal plasma oGH or somatostatin, nor did pretreatment with 50 micrograms bGH significantly alter GH response to clonidine stimulation, although the change in plasma GH with stimulation was only half that of controls.
GH Neg (not) Regulation (affect) of oGH in plasma associated with somatostatin and clonidine
1) Confidence 0.10 Published 1997 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 9366031 Disease Relevance 0 Pain Relevance 0.24
Human GH also failed to alter plasma oGH when given at a dose of 50 micrograms i.c.v.
GH Neg (failed) Regulation (alter) of oGH in plasma
2) Confidence 0.08 Published 1997 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 9366031 Disease Relevance 0 Pain Relevance 0.22

General Comments

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