INT72216

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 1.36
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
neuronal 2
oocytes 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 70 100.00 Very High Very High Very High
mu opioid receptor 15 100.00 Very High Very High Very High
Neuropathic pain 3 95.76 Very High Very High Very High
agonist 172 95.36 Very High Very High Very High
Opioid 3 93.80 High High
nMDA receptor 9 91.84 High High
chemokine 6 89.28 High High
Morphine 3 88.28 High High
Endogenous opioid 3 85.92 High High
Analgesic 3 84.76 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 6 98.46 Very High Very High Very High
Neuropathic Pain 3 95.76 Very High Very High Very High
Cervical Cancer 1 95.36 Very High Very High Very High
Fibrosis 37 91.20 High High
Stress 111 86.08 High High
INFLAMMATION 59 82.52 Quite High
Injury 48 73.96 Quite High
Liver Disease 43 72.36 Quite High
Cirrhosis 45 65.28 Quite High
Wound Healing 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possibility is that PKC activation regulates MuOR mRNA expression and thus the ability to generate functional receptors.
Regulation (regulates) of Positive_regulation (activation) of PKC associated with kinase c and mu opioid receptor
1) Confidence 0.37 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.17 Pain Relevance 0.93
CONCLUSIONS: Mu opioid receptor mRNA levels are regulated by activation of PKC in a neuronal model.
Regulation (regulated) of Positive_regulation (activation) of PKC in neuronal
2) Confidence 0.37 Published 1997 Journal Anesthesiology Section Body Doc Link 9366465 Disease Relevance 0.06 Pain Relevance 0
Using a human neuroblastoma cell line, the authors tested the hypothesis that phorbol ester activation of PKC regulates MuOR mRNA levels.
Regulation (regulates) of Positive_regulation (activation) of PKC associated with neuroblastoma, kinase c and mu opioid receptor
3) Confidence 0.37 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.26 Pain Relevance 0.88
The effect of PKC activation was abolished in the presence of bupivacaine.
Regulation (effect) of Positive_regulation (activation) of PKC
4) Confidence 0.36 Published 2006 Journal Br J Anaesth Section Body Doc Link 16299047 Disease Relevance 0 Pain Relevance 0
We also determined the effect of the protein kinase C (PKC) inhibitors chelerythrine (5 x 10(-5) M), calphostin C (3 x 10(-6) M) and Ro 31-8220 (10(-7) M), and the effect of PKC activation with phorbolester (10(-6) M).
Regulation (effect) of Positive_regulation (activation) of PKC
5) Confidence 0.36 Published 2006 Journal Br J Anaesth Section Body Doc Link 16299047 Disease Relevance 0 Pain Relevance 0
Consistent with this, the results of the present study also suggest the involvement of PKC inhibition in the down-regulation of hTERT gene transcription and PKC activation in the upregulation of hTERT gene transcription.
Regulation (regulation) of Positive_regulation (activation) of PKC associated with kinase c
6) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.10 Pain Relevance 0.48
The two-electrode voltage-clamp technique was used to evaluate the effect of protein kinase C (PKC) activation on ion current flow in Xenopus laevis oocytes injected with cRNA coding for the human vanilloid receptor (VR1).
Regulation (effect) of Positive_regulation (activation) of PKC in oocytes associated with kinase c
7) Confidence 0.18 Published 2002 Journal Pain Section Abstract Doc Link 12098622 Disease Relevance 0 Pain Relevance 0.43
-regulated PKC activation and phosphorylation of Ser145 and Thr337 and another involving eNOS phosphorylation and activation leading the NO/cGMP-regulated PKG phosphorylation of Ser331.
Regulation (regulated) of Positive_regulation (activation) of PKC
8) Confidence 0.12 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
-regulated PKC activation and phosphorylation of Ser145 and Thr337 and another involving eNOS phosphorylation and activation leading the NO/cGMP-regulated PKG phosphorylation of Ser331.
Regulation (involving) of Positive_regulation (activation) of PKC
9) Confidence 0.12 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
B and more likely operates through an AP-1-related mechanism [288], possibly involving activation of PKC [282], as shown for the PKC?
Regulation (through) of Positive_regulation (activation) of PKC
10) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.77 Pain Relevance 0.22

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