INT72218

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Context Info
Confidence 0.08
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.62
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (METTL3) methyltransferase activity (METTL3) RNA binding (METTL3)
nucleus (METTL3)
Anatomy Link Frequency
salivary glands 1
METTL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 5 100.00 Very High Very High Very High
Kinase C 52 99.74 Very High Very High Very High
Neuropathic pain 1 87.32 High High
Opioid 1 85.36 High High
nMDA receptor 1 83.40 Quite High
addiction 24 82.00 Quite High
Morphine 1 79.84 Quite High
Endogenous opioid 1 77.48 Quite High
Analgesic 1 76.32 Quite High
anesthesia 12 67.36 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 98.10 Very High Very High Very High
Syndrome 10 96.80 Very High Very High Very High
Salivary Gland Disease 6 94.48 High High
Neuropathic Pain 1 87.32 High High
Systemic Inflammatory Response Syndrome 44 78.88 Quite High
Anastomotic Leak 18 76.80 Quite High
Pneumonia 16 73.60 Quite High
Sialorrhea 2 68.56 Quite High
Cancer 68 66.88 Quite High
Recurrence 2 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a human neuroblastoma cell line, the authors tested the hypothesis that phorbol ester activation of PKC regulates MuOR mRNA levels.
Regulation (regulates) of MuOR mRNA associated with neuroblastoma, kinase c and mu opioid receptor
1) Confidence 0.08 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.26 Pain Relevance 0.87
Saliva is also a good tool to detect systemic changes of mRNA and proteome because it is blended with contaminating blood, gingival crevicular fluid, mucosal transudate and also ultrafiltrate of the salivary glands' acini [2] (Fig. 2).
Regulation (changes) of mRNA in salivary glands associated with salivary gland disease
2) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674305 Disease Relevance 0.30 Pain Relevance 0
However, only a little correlation of the change of the amount of a certain protein and the alterations of its mRNA level were found under a particular pathological condition, like the Sjögren's syndrome [26].
Neg (little) Regulation (alterations) of mRNA associated with syndrome
3) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674305 Disease Relevance 0.17 Pain Relevance 0
The AUC of IL-6 mRNA and IL-6 was 0.809 and 0.453, respectively, and the predictive cut-off value of IL-6 mRNA was 3400 as a relative ratio to the ?
Regulation (value) of mRNA
4) Confidence 0.00 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.35 Pain Relevance 0.17
The mean/median/cutoff values of IL-6 mRNA are 5906/2810/5900 and, in Kaplan-Meyer survival analysis; if they did not demonstrate significant value among clinical parameters, we concluded that IL-6 mRNA was not an indicative marker for outcome.
Regulation (values) of mRNA
5) Confidence 0.00 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.54 Pain Relevance 0.10
mRNA levels were not affected by the addition of 25OH-C.
Neg (not) Regulation (affected) of mRNA
6) Confidence 0.00 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0

General Comments

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