INT72219

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Context Info
Confidence 0.24
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 9.58
Pain Relevance 7.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (METTL3) methyltransferase activity (METTL3) RNA binding (METTL3)
nucleus (METTL3)
Anatomy Link Frequency
blood 1
myometrium 1
colon 1
band 1
T24 1
METTL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 8 100.00 Very High Very High Very High
Kinase C 1227 99.84 Very High Very High Very High
Inflammation 114 99.72 Very High Very High Very High
agonist 104 99.10 Very High Very High Very High
Opioid 6 97.88 Very High Very High Very High
addiction 110 97.60 Very High Very High Very High
Neuropathic pain 1 94.76 High High
Chronic pancreatitis 2 93.76 High High
nMDA receptor 1 90.84 High High
anesthesia 54 90.40 High High
Disease Link Frequency Relevance Heat
Colon Cancer 26 99.84 Very High Very High Very High
INFLAMMATION 149 99.72 Very High Very High Very High
Targeted Disruption 52 99.52 Very High Very High Very High
Anastomotic Leak 81 99.32 Very High Very High Very High
Systemic Inflammatory Response Syndrome 198 98.84 Very High Very High Very High
Cancer 536 98.80 Very High Very High Very High
Pneumonia 72 98.48 Very High Very High Very High
Opiate Addiction 2 97.88 Very High Very High Very High
Esophageal Cancer 117 97.84 Very High Very High Very High
Pancreatic Cancer 12 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of mu opioid receptor splice variants mRNA in human blood lymphocytes: a peripheral marker for opioid addiction studies.
Gene_expression (Expression) of variants mRNA in blood associated with addiction, mu opioid receptor and opioid
1) Confidence 0.24 Published 2009 Journal Int. Immunopharmacol. Section Title Doc Link 19272466 Disease Relevance 0.10 Pain Relevance 0.74
There was a significant correlation between enhanced hpa mRNA expression and shorter postoperative patient survival. hpa mRNA and protein localized in the cancer cells of primary and metastatic pancreatic cancer, with a preferentially higher expression at the primary tumor site.
Gene_expression (expression) of mRNA associated with cancer and pancreatic cancer
2) Confidence 0.20 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11406531 Disease Relevance 1.10 Pain Relevance 0.14
There was a significant correlation between enhanced hpa mRNA expression and shorter postoperative patient survival. hpa mRNA and protein localized in the cancer cells of primary and metastatic pancreatic cancer, with a preferentially higher expression at the primary tumor site.
Gene_expression (expression) of mRNA associated with cancer and pancreatic cancer
3) Confidence 0.20 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11406531 Disease Relevance 1.12 Pain Relevance 0.14
These results have also been confirmed by studying OR mRNA expression in the VZ and SVZ.
Gene_expression (expression) of OR mRNA
4) Confidence 0.19 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18455254 Disease Relevance 0.16 Pain Relevance 0.36
One possibility is that PKC activation regulates MuOR mRNA expression and thus the ability to generate functional receptors.
Gene_expression (expression) of MuOR mRNA associated with kinase c and mu opioid receptor
5) Confidence 0.14 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.17 Pain Relevance 0.92
Real-time PCR revealed a significant, five- to sevenfold increase in the expression of PKCbeta mRNA in the preterm and term myometrium when compared with the nonpregnant myometrium.
Gene_expression (expression) of mRNA in myometrium
6) Confidence 0.02 Published 2007 Journal Reproduction Section Abstract Doc Link 17504923 Disease Relevance 0 Pain Relevance 0.08
The co-existence of a certain protein sequence and its own mRNA is detectable in a rather high proportion of proteins with exact values ranging between 70% to 93%, which is depending on the actual methods used [32].
Gene_expression (detectable) of mRNA
7) Confidence 0.02 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674305 Disease Relevance 0.07 Pain Relevance 0
Although this opinion seems to be a bit exaggerated [29] (see below), but we would like to point out that caution should be used in interpreting saliva-based mRNA expression studies without the technical exclusion of possible DNA contamination artifacts [28, 29].
Gene_expression (expression) of mRNA in saliva
8) Confidence 0.02 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674305 Disease Relevance 0 Pain Relevance 0
mol/l all-trans-retinoic acid for 24 hours; however, others performing similar experiments have reported unchanged Tg mRNA expression [25].
Gene_expression (expression) of mRNA
9) Confidence 0.02 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2739165 Disease Relevance 0.26 Pain Relevance 0.04
EGR1 and IL-6 mRNA expression correlated with anastomotic leak and pneumonia at POD 3 by regression analysis (p = 0.021, Table 4).
Gene_expression (expression) of mRNA associated with anastomotic leak and pneumonia
10) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.80 Pain Relevance 0.19
Circulating mRNA expression during hospitalization
Gene_expression (expression) of mRNA
11) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.14 Pain Relevance 0
Therapeutic use of Sivelestat (ElaspolĀ®, Ono Pharmaceutical Co., Ltd.) significantly correlated with MUC1 and NAMPT mRNA expression (p = 0.048 and 0.045).
Gene_expression (expression) of mRNA
12) Confidence 0.01 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2984412 Disease Relevance 0.51 Pain Relevance 0.20
We measured serum mRNA levels of 11 inflammatory-related genes in 27 post-esophagectomy patients admitted to the intensive care unit (ICU).
Gene_expression (levels) of mRNA associated with inflammation
13) Confidence 0.01 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2984412 Disease Relevance 0.27 Pain Relevance 0.05
mRNA expression correlated with duration of SIRS (p = 0.042).
Gene_expression (expression) of mRNA associated with systemic inflammatory response syndrome
14) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.24 Pain Relevance 0.13
Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study

Background

Gene_expression (expression) of mRNA associated with esophageal cancer
15) Confidence 0.01 Published 2010 Journal J Transl Med Section Title Doc Link PMC2984412 Disease Relevance 0.26 Pain Relevance 0.04
The mRNA expression profiles over the 14 days are shown in Figure 1.
Gene_expression (expression) of mRNA
16) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.14 Pain Relevance 0
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Gene_expression (levels) of mRNA
17) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.49
We measured serum mRNA levels for 14 days postoperatively.
Gene_expression (levels) of mRNA
18) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.82 Pain Relevance 0.06
transcript levels increased over 12 hours, demonstrating the high specificity of the inhibitory effect of 25OH-C on c-myc mRNA expression.


Gene_expression (expression) of mRNA
19) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
Due to the negative regulation of the c-myc mRNA expression by 25OH-C, the addition of 25OH-C to this culture system was expected to further decrease c-myc and hTERT mRNA levels while not affecting the decline of PPAR?
Gene_expression (expression) of mRNA
20) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0

General Comments

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