INT72220

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Context Info
Confidence 0.10
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.76
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (METTL3) methyltransferase activity (METTL3) RNA binding (METTL3)
nucleus (METTL3)
METTL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 9 100.00 Very High Very High Very High
anesthesia 12 77.56 Quite High
orphanin 4 76.88 Quite High
addiction 24 68.24 Quite High
Inflammation 24 67.36 Quite High
iatrogenic 2 64.84 Quite High
Opioid 3 63.28 Quite High
MU agonist 1 62.04 Quite High
Kinase C 104 50.00 Quite Low
mu opioid receptor 10 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 8 96.12 Very High Very High Very High
Esophageal Cancer 26 93.52 High High
Systemic Inflammatory Response Syndrome 44 89.08 High High
Sepsis 16 88.56 High High
Anastomotic Leak 18 87.20 High High
Aspiration Pneumonia 2 85.60 High High
Neuroblastoma 7 82.16 Quite High
INFLAMMATION 28 67.36 Quite High
Lung Injury 4 65.32 Quite High
Pneumonia 16 59.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: MuOR mRNA levels decreased in a dose- and time-dependent manner after tetradecanoyl phorbol acetate (TPA) was administered to activate PKC.
Negative_regulation (decreased) of MuOR mRNA
1) Confidence 0.10 Published 1997 Journal Anesthesiology Section Body Doc Link 9366465 Disease Relevance 0.08 Pain Relevance 0
Protein kinase C effects which decrease MuOR mRNA levels appear largely independent of new protein synthesis, and cytotoxicity does not account for the findings.
Negative_regulation (decrease) of MuOR mRNA
2) Confidence 0.10 Published 1997 Journal Anesthesiology Section Body Doc Link 9366465 Disease Relevance 0.05 Pain Relevance 0
Activation of the cAMP-PKA signal transduction pathway with forskolin in the presence of phosphodiesterase inhibitors was associated with a time-dependent decrease in the level of MuOR mRNA; partial recovery was observed with prolonged incubations.
Negative_regulation (decrease) of MuOR mRNA associated with opioid receptor
3) Confidence 0.02 Published 2002 Journal Brain Res. Section Abstract Doc Link 12106667 Disease Relevance 0.24 Pain Relevance 0.59
Four patients (#11, 13, 16, 20) received long-term sivelestat and displayed significant downregulation of NAMPT and MUC1 mRNA (p < 0.001 and 0.034 by one-way ANOVA) compared with the 23 patients who did not receive this medication.
Negative_regulation (downregulation) of mRNA
4) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.89 Pain Relevance 0.12
IL-6 mRNA was upregulated in the immediate perioperative period (POD 0, Figure 3a) and gradually decreased at POD 3.
Negative_regulation (decreased) of mRNA
5) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.38 Pain Relevance 0.17
In the cells exposed to growth medium containing 10% NHS alone, Receptor Ck was activated by the cholesterol moiety of low density lipoprotein (LDL) supplied by 10% NHS and a decrease in the mRNA levels of hTERT, c-myc and PPAR?
Negative_regulation (decrease) of mRNA
6) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.11 Pain Relevance 0
The exposure of PBMCs to growth medium containing 10% NHS had resulted in a gradual decrease in the mRNA levels of c-myc, PPAR?
Negative_regulation (decrease) of mRNA
7) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0

General Comments

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