INT72221

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Context Info
Confidence 0.81
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 1.23
Pain Relevance 11.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
plasma 2
SH-SY5Y 1
tail 1
internal 1
nucleus 1
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 272 100.00 Very High Very High Very High
nMDA receptor 1 100.00 Very High Very High Very High
Opioid 31 99.92 Very High Very High Very High
fluoxetine 18 99.68 Very High Very High Very High
Enkephalin 8 99.66 Very High Very High Very High
addiction 2 99.22 Very High Very High Very High
Morphine 3 98.84 Very High Very High Very High
Endogenous opioid 1 96.48 Very High Very High Very High
Neuropathic pain 1 95.84 Very High Very High Very High
Analgesic 5 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 10 99.52 Very High Very High Very High
Neuropathic Pain 1 95.84 Very High Very High Very High
Small Cell Lung Cancer 3 95.12 Very High Very High Very High
Non-small-cell Lung Cancer 4 93.20 High High
Hyperplasia 5 91.44 High High
Cancer 54 83.32 Quite High
Disease 61 76.48 Quite High
INFLAMMATION 28 59.68 Quite High
Hypersensitivity 4 59.00 Quite High
Mental Disorders 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, when submitogenic Con A concentrations (1 microgram/ml) were used, fluoxetine stimulated the cellular response and increased PKC translocation.
Localization (translocation) of PKC associated with kinase c and fluoxetine
1) Confidence 0.81 Published 1998 Journal Acta Physiol Pharmacol Ther Latinoam Section Abstract Doc Link 9914808 Disease Relevance 0.09 Pain Relevance 0.75
According to our results, fluoxetine seems to modulate calcium influx which, in turn, would influence PKC translocation, thus modulating the immune response through a mechanism that could be involving cAMP participation.
Localization (translocation) of PKC associated with kinase c and fluoxetine
2) Confidence 0.81 Published 1998 Journal Acta Physiol Pharmacol Ther Latinoam Section Abstract Doc Link 9914808 Disease Relevance 0.08 Pain Relevance 0.71
[D-Ala2,N-Me-Phe4,Gly-ol]enkephalin (DAMGO)-induced PKC translocation follows a time-dependent and biphasic pattern beginning 2 h after opioid addition, when a pronounced translocation of PKC to the plasma membrane occurs.
Localization (translocation) of PKC in plasma associated with kinase c, enkephalin and opioid
3) Confidence 0.80 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.09 Pain Relevance 1.51
In this series of experiments, we continue our investigation of how opioid-activated PKC contributes to homologous receptor down-regulation and then expand our focus to include the exploration of the mechanism(s) by which mu-opioids produce PKC translocation in SH-SY5Y neuroblastoma cells.
Localization (translocation) of PKC in SH-SY5Y associated with neuroblastoma, kinase c and opioid
4) Confidence 0.80 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.10 Pain Relevance 1.38
[D-Ala2,N-Me-Phe4,Gly-ol]enkephalin (DAMGO)-induced PKC translocation follows a time-dependent and biphasic pattern beginning 2 h after opioid addition, when a pronounced translocation of PKC to the plasma membrane occurs.
Localization (translocation) of PKC in plasma associated with kinase c, enkephalin and opioid
5) Confidence 0.80 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.10 Pain Relevance 1.45
In contrast, when suboptimal concanavalin A concentrations were used, fluoxetine only increased PKC translocation, without modifying cAMP levels, leading to T-cell proliferation.
Localization (translocation) of PKC in T-cell associated with kinase c and fluoxetine
6) Confidence 0.78 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374716 Disease Relevance 0 Pain Relevance 0.74
PKC-zeta translocates from the cytosol to the membrane with kinetics similar to those of PKC-alpha and epsilon in response to DAMGO but does not undergo reverse translocation after longer exposure times.
Localization (translocates) of PKC associated with kinase c
7) Confidence 0.70 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0 Pain Relevance 1.46
The above and the realization of selective translocation of PKC with preconditioning, [27,28,31] suggest that PKC may play a dual role upstream and downstream of mitoKATP channels.
Localization (translocation) of PKC associated with kinase c
8) Confidence 0.68 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.31
Activation and translocation of protein kinase C (PKC) by N-methyl-D-aspartate receptor stimulation correlates with resistance to opioid drugs in experimental states of neuropathic pain, but the cellular mechanisms of resistance have not been identified.
Localization (translocation) of PKC associated with kinase c, nmda receptor, neuropathic pain and opioid
9) Confidence 0.66 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.17 Pain Relevance 0.95
PKC may then translocate to various cellular sites including the mitochondria, sarcolemma and intercalated discs, and nucleus, a phenomena that may involve specific PKC isoforms, where p38MAPK will be activated.
Localization (translocate) of PKC in nucleus associated with kinase c
10) Confidence 0.64 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.35
Hence, PKC was implicated in the Receptor Ck signaling pathway controlling the transcription of c-myc, PPAR?
Localization (implicated) of PKC associated with kinase c
11) Confidence 0.34 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.41
One such example is the recently published results of a phase III trial of the drug, Affinitak, directed against PKC?
Localization (directed) of PKC associated with kinase c
12) Confidence 0.25 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.60 Pain Relevance 0.12
and clearly indicates that both Ser145 and Thr337 within the IC2 and C-tail domains are functional PKC targets.
Localization (targets) of PKC in tail
13) Confidence 0.19 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
may contribute to the PKG-, or indeed PKC-, induced desensitization of TP?.
Localization (desensitization) of PKC
14) Confidence 0.19 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11
Other coincident actions include DAT trafficking caused by amphetamines and some estrogens (though sometimes in different directions),149,150 and the dependence of efflux caused by both compounds on PKC actions and release of intracellular calcium stores.
Localization (release) of PKC associated with addiction
15) Confidence 0.13 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0 Pain Relevance 0.19
Western blot analysis revealed that tetracaine prevented the membrane translocation of PLD-activating factors, ADP-ribosylation factor, RhoA, and protein kinase Calpha.
Localization (translocation) of protein kinase Calpha
16) Confidence 0.12 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10591142 Disease Relevance 0 Pain Relevance 0.74
The net effect of increased IP3 and DAG levels is to increase intracellular Ca2+ through release from internal stores and influx from membrane-bound channels [3], and in ASM to activate the cell's contractile machinery through both Ca2+ and protein kinase C (PKC) -dependent mechanisms [30-33] (see Fig. 1 Legend for details).
Localization (release) of PKC in internal associated with kinase c
17) Confidence 0.10 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.17

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