INT72222

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.55
Pain Relevance 6.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
plasma 2
SH-SY5Y 2
T-cell 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 113 100.00 Very High Very High Very High
nMDA receptor 1 100.00 Very High Very High Very High
fluoxetine 18 99.98 Very High Very High Very High
Opioid 13 99.98 Very High Very High Very High
Enkephalin 4 99.84 Very High Very High Very High
Morphine 1 99.44 Very High Very High Very High
Endogenous opioid 1 97.08 Very High Very High Very High
Analgesic 3 95.92 Very High Very High Very High
Neuropathic pain 1 95.84 Very High Very High Very High
mu opioid receptor 5 92.28 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 6 99.52 Very High Very High Very High
Neuropathic Pain 1 95.84 Very High Very High Very High
Hyperplasia 3 93.32 High High
Targeted Disruption 2 36.88 Quite Low
Cancer 16 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Thrombosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, when submitogenic Con A concentrations (1 microgram/ml) were used, fluoxetine stimulated the cellular response and increased PKC translocation.
Positive_regulation (stimulated) of Localization (translocation) of PKC associated with kinase c and fluoxetine
1) Confidence 0.70 Published 1998 Journal Acta Physiol Pharmacol Ther Latinoam Section Abstract Doc Link 9914808 Disease Relevance 0.09 Pain Relevance 0.77
In contrast, when suboptimal concanavalin A concentrations were used, fluoxetine only increased PKC translocation, without modifying cAMP levels, leading to T-cell proliferation.
Positive_regulation (increased) of Localization (translocation) of PKC in T-cell associated with kinase c and fluoxetine
2) Confidence 0.68 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374716 Disease Relevance 0 Pain Relevance 0.74
In this series of experiments, we continue our investigation of how opioid-activated PKC contributes to homologous receptor down-regulation and then expand our focus to include the exploration of the mechanism(s) by which mu-opioids produce PKC translocation in SH-SY5Y neuroblastoma cells.
Positive_regulation (produce) of Localization (translocation) of PKC in SH-SY5Y associated with neuroblastoma, kinase c and opioid
3) Confidence 0.50 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.10 Pain Relevance 1.38
[D-Ala2,N-Me-Phe4,Gly-ol]enkephalin (DAMGO)-induced PKC translocation follows a time-dependent and biphasic pattern beginning 2 h after opioid addition, when a pronounced translocation of PKC to the plasma membrane occurs.
Positive_regulation (-induced) of Localization (translocation) of PKC in plasma associated with kinase c, enkephalin and opioid
4) Confidence 0.50 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.10 Pain Relevance 1.45
On the other hand, when submitogenic Con A concentrations (1 microgram/ml) were used, fluoxetine stimulated the cellular response and increased PKC translocation.
Positive_regulation (increased) of Localization (translocation) of PKC associated with kinase c and fluoxetine
5) Confidence 0.47 Published 1998 Journal Acta Physiol Pharmacol Ther Latinoam Section Abstract Doc Link 9914808 Disease Relevance 0.09 Pain Relevance 0.76
Activation and translocation of protein kinase C (PKC) by N-methyl-D-aspartate receptor stimulation correlates with resistance to opioid drugs in experimental states of neuropathic pain, but the cellular mechanisms of resistance have not been identified.
Positive_regulation (Activation) of Localization (translocation) of PKC associated with kinase c, nmda receptor, neuropathic pain and opioid
6) Confidence 0.41 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.17 Pain Relevance 0.95
Hence, PKC was implicated in the Receptor Ck signaling pathway controlling the transcription of c-myc, PPAR?
Positive_regulation (Hence) of Localization (implicated) of PKC associated with kinase c
7) Confidence 0.22 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.41
may contribute to the PKG-, or indeed PKC-, induced desensitization of TP?.
Positive_regulation (induced) of Localization (desensitization) of PKC
8) Confidence 0.13 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11

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