INT72237

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Context Info
Confidence 0.25
First Reported 1997
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AP1M2) protein targeting (AP1M2) Golgi apparatus (AP1M2)
Anatomy Link Frequency
brains 1
AP1M2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
opiate 6 100.00 Very High Very High Very High
Opioid receptor 1 2 100.00 Very High Very High Very High
Opioid 2 99.84 Very High Very High Very High
Morphine 5 84.48 Quite High
Neurotransmitter 1 78.16 Quite High
Kappa opioid receptor 3 75.00 Quite High
Central nervous system 3 73.32 Quite High
narcan 3 25.00 Low Low
Enkephalin 3 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the two main mu opiate receptor subtypes, mu1 and mu2, our laboratory has demonstrated a third mu opiate receptor (mu3) that is selective for opiate alkaloids but insensitive to opioid peptides.
mu2 Binding (insensitive) of associated with opioid receptor 1, opiate and opioid
1) Confidence 0.25 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173675 Disease Relevance 0 Pain Relevance 1.20
At 4 degrees C mu1, mu2, delta, kappa1 and kappa3 binding remained constant over the 24 hour period.
mu2 Binding (binding) of
2) Confidence 0.16 Published 1997 Journal Life Sci. Section Abstract Doc Link 9366506 Disease Relevance 0 Pain Relevance 0.23
At room temperature mu1, mu2 and delta opioid receptor binding was reduced between 6 and 12 hours, whereas kappa1 and kappa3 binding was reduced after 24 hours.
mu2 Binding (binding) of associated with opioid receptor
3) Confidence 0.16 Published 1997 Journal Life Sci. Section Abstract Doc Link 9366506 Disease Relevance 0 Pain Relevance 0.25
Tissue homogenates from these brains were analysed for mu1, mu2, delta, kappa1 and kappa3 opioid receptor binding using standard radioligand binding techniques.
mu2 Spec (analysed) Binding (binding) of in brains associated with opioid receptor
4) Confidence 0.16 Published 1997 Journal Life Sci. Section Abstract Doc Link 9366506 Disease Relevance 0 Pain Relevance 0.26

General Comments

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