INT7224

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 10.22
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 6
juvenile 2
muscle 2
pituitary 2
tubules 2
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 2 100.00 Very High Very High Very High
narcan 27 99.98 Very High Very High Very High
Opioid 11 98.40 Very High Very High Very High
antagonist 5 98.12 Very High Very High Very High
fibrosis 1 97.76 Very High Very High Very High
Endogenous opioid 4 97.34 Very High Very High Very High
ketamine 2 96.72 Very High Very High Very High
opioid receptor 3 93.84 High High
opiate 5 92.28 High High
Hippocampus 4 92.24 High High
Disease Link Frequency Relevance Heat
Hyperandrogenism 1 99.92 Very High Very High Very High
Targeted Disruption 21 99.56 Very High Very High Very High
Ovarian Cancer 1 99.08 Very High Very High Very High
Cognitive Disorder 80 98.48 Very High Very High Very High
Fibrosis 1 97.76 Very High Very High Very High
Reprotox - General 2 2 97.52 Very High Very High Very High
Reprotox - General 1 17 96.28 Very High Very High Very High
Disease 240 95.68 Very High Very High Very High
Sprains And Strains 10 94.72 High High
Galactorrhea 4 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
altered in the LH overexpressing mice, we also measured Y-maze
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of LH
1) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.52 Pain Relevance 0.04
LH overexpressers show elevated rather than diminished levels of
Positive_regulation (elevated) of Gene_expression (overexpressers) of LH
2) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.21 Pain Relevance 0.06
LH overexpressers show elevated rather than diminished levels of
Positive_regulation (overexpressers) of Gene_expression (overexpressers) of LH
3) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.21 Pain Relevance 0.06
The IEF fractionation separated plasma LH into 6 distinct species in terms of pI values.
Positive_regulation (separated) of Gene_expression (separated) of LH in plasma
4) Confidence 0.44 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.11
Alternatively, release of endogenous opioids in association with increasing feed intake or other lactational hormone responses may provide neural or pituitary inhibition of the pulsatile LH production that is requisite for ovarian follicular development.
Positive_regulation (pulsatile) of Gene_expression (production) of LH in pituitary associated with endogenous opioid
5) Confidence 0.44 Published 1989 Journal J. Dairy Sci. Section Abstract Doc Link 2654227 Disease Relevance 0.08 Pain Relevance 0.10
overexpresses LH [116–118] and have found that these
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of LH
6) Confidence 0.39 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.60 Pain Relevance 0.05
Increases in LH levels, LH area under the curve, FSH levels, and the number of LH pulses per 6 h were observed in all patients, 2-8 h after the beginning of naltrexone administration.
Positive_regulation (Increases) of Gene_expression (levels) of LH
7) Confidence 0.37 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7745028 Disease Relevance 0 Pain Relevance 0.13
Using tamoxifen, an anti-oestrogenic drug, which stimulates LH and FSH production, we not only observed normal physiological resting testosterone values and a restoration of the testosterone/cortisol ratio after exercise, but our patient also experienced a higher sexual drive, well being and a spectacular decrease in the muscle injury rate.
Positive_regulation (stimulates) of Gene_expression (production) of LH in muscle associated with injury
8) Confidence 0.33 Published 1995 Journal Int J Sports Med Section Abstract Doc Link 7591395 Disease Relevance 0.81 Pain Relevance 0
Circulating levels of serum LH were elevated to the same extent (approximately 400%) in response to GnRH (100 micrograms) in animals 1-5 years old (juvenile) and in animals 6-9 years old (pubertal).
Positive_regulation (elevated) of Gene_expression (levels) of LH in juvenile
9) Confidence 0.29 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1742612 Disease Relevance 0 Pain Relevance 0.47
Thus, when pubertal increases in LH production eventually occur and thereby stimulate androgen production, the somatic cell complement within the tubules has already been established and will support the androgen-driven spermatogenesis.


Positive_regulation (increases) of Gene_expression (production) of LH in tubules
10) Confidence 0.26 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
For this purpose, the effect of ANG II (infusion for 60 min of successively increasing doses of 4, 8 and 16 ng/kg/min; each dose for 20 min) on serum LH levels was evaluated during administration of saline or the opioid antagonist naloxone (4 mg in an i.v. bolus followed by 10 mg over 2 h) in 7 normal women in both follicular and luteal phase.
Positive_regulation (evaluated) of Gene_expression (levels) of LH associated with antagonist, narcan and opioid
11) Confidence 0.19 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 8059012 Disease Relevance 0 Pain Relevance 0.45
Elevated plasma levels of LH and FSH show adequate reaction of the hypothalamohypophyseal unit.
Positive_regulation (Elevated) of Gene_expression (levels) of LH in plasma
12) Confidence 0.17 Published 1990 Journal Zentralbl Gynakol Section Abstract Doc Link 2238981 Disease Relevance 0.91 Pain Relevance 0.16
mol in combination with LH, the values on P4 accumulation became intermediate between those observe for basal and LH alone (Fig. 6); and the stimulatory effect of LH was completely eliminated by 1000 ?
Positive_regulation (observe) of Gene_expression (alone) of LH
13) Confidence 0.15 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0
Naloxone induced a marked rise in both LH and FSH levels in all of the five hyperprolactinaemic patients.
Positive_regulation (induced) of Gene_expression (levels) of LH associated with narcan
14) Confidence 0.12 Published 1982 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6814795 Disease Relevance 1.08 Pain Relevance 0.45
During early lactation the LH SM cannot be activated by OB, while during late lactation a partial recovery of the LH SM occurs.
Spec (partial) Positive_regulation (recovery) of Spec (partial) Gene_expression (recovery) of LH SM
15) Confidence 0.09 Published 1992 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 1343977 Disease Relevance 0 Pain Relevance 0.53
At the other end of the spectrum, in polycystic ovarian syndrome, LH (GnRH) pulses are persistently rapid and favor LH synthesis, hyperandrogenism and impaired follicular maturation.
Positive_regulation (favor) of Gene_expression (synthesis) of LH associated with ovarian cancer and hyperandrogenism
16) Confidence 0.09 Published 2001 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 11604221 Disease Relevance 0.29 Pain Relevance 0.24
In no case did administration of naloxone disrupt the temporal correlation between experimentally induced increases in plasma beta-endorphin and decreases in plasma LH.
Positive_regulation (increases) of Gene_expression (decreases) of LH in plasma associated with narcan
17) Confidence 0.08 Published 1987 Journal J. Reprod. Fertil. Suppl. Section Abstract Doc Link 2957499 Disease Relevance 0 Pain Relevance 0.26
Alternatively, increased serum levels of LH and FSH can be observed in old men either because of primary hypogonadism or to decreased hypothalamic opioid tone.
Positive_regulation (increased) of Gene_expression (levels) of LH associated with reprotox - general 2 and opioid
18) Confidence 0.05 Published 2000 Journal Exp. Gerontol. Section Abstract Doc Link 11113607 Disease Relevance 0.55 Pain Relevance 0.14
Growth hormone (GH) response to clonidine provocation, LH and FSH response to LHRH stimulation, and in boys testosterone (T) response to HCG were evaluated.
Positive_regulation (response) of Gene_expression (evaluated) of LH associated with clonidine
19) Confidence 0.04 Published 1997 Journal J. Trop. Pediatr. Section Abstract Doc Link 9078821 Disease Relevance 0.94 Pain Relevance 0.16

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