INT72249

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.08
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ABP1) oxidoreductase activity (ABP1) extracellular region (ABP1)
plasma membrane (ABP1) peroxisome (ABP1)
Anatomy Link Frequency
Lens 2
kidney 2
ABP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 15 99.12 Very High Very High Very High
anesthesia 5 82.04 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 40 99.84 Very High Very High Very High
Cognitive Disorder 40 98.48 Very High Very High Very High
Pneumoperitoneum 22 95.92 Very High Very High Very High
Stress 10 93.60 High High
Aging 2 77.04 Quite High
Pressure Volume 2 Under Development 1 75.96 Quite High
Dementia 3 61.56 Quite High
Acidosis 7 54.88 Quite High
Mental Disorders 1 33.84 Quite Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Competitive inhibition of swine kidney copper amine oxidase by diuretic, antihypertensive, and anticoagulant drugs, amiloride, clonidine, and gabexate mesylate, respectively, is reported.
Negative_regulation (inhibition) of amine oxidase in kidney associated with clonidine
1) Confidence 0.36 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9367901 Disease Relevance 0 Pain Relevance 0.24
Competitive inhibition of swine kidney copper amine oxidase by drugs: amiloride, clonidine, and gabexate mesylate.
Negative_regulation (inhibition) of amine oxidase in kidney associated with clonidine
2) Confidence 0.36 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9367901 Disease Relevance 0 Pain Relevance 0.27
We found that serum AOC is reduced in AD patients and is associated with their cognitive scores.
Negative_regulation (reduced) of serum AOC associated with cognitive disorder and disease
3) Confidence 0.33 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1420275 Disease Relevance 0.85 Pain Relevance 0
Competitive inhibition of Lens culinaris L. copper amine oxidase by amiloride, p-aminobenzamidine, clonidine, 4',6-diamidino-2-phenylindole and gabexate mesylate: a comparative study.
Negative_regulation (inhibition) of amine oxidase in Lens associated with clonidine
4) Confidence 0.33 Published 1998 Journal J. Enzym. Inhib. Section Title Doc Link 9825309 Disease Relevance 0 Pain Relevance 0.27
The competitive inhibition of Lens culinaris L. copper amine oxidase by amiloride (Ki = 4.1 x 10(-4) M), p-aminobenzamidine (Ki = 6.0 x 10(-4) M), clonidine (Ki = 5.0 x 10(-4) M), 4',6-diamidino-2-phenylindole (DAPI; Ki = 1.9 x 10(-5) M) and gabexate mesylate (Ki = 2.5 x 10(-4) M) has been investigated, at pH 7.0 and 25 degrees C.
Spec (investigated) Negative_regulation (inhibition) of amine oxidase in Lens associated with clonidine
5) Confidence 0.33 Published 1998 Journal J. Enzym. Inhib. Section Abstract Doc Link 9825309 Disease Relevance 0 Pain Relevance 0.25
Thus, amiloride and gabexate mesylate may represent useful model compounds for the development of selective inhibitors of mammalian copper amine oxidase, which may be important in view of the potential use of plant copper amine oxidase as drugs.
Negative_regulation (inhibitors) of amine oxidase
6) Confidence 0.25 Published 1998 Journal J. Enzym. Inhib. Section Abstract Doc Link 9825309 Disease Relevance 0 Pain Relevance 0.24
After declamping

(T5), a significant increase in CO and SV and a significant decrease in ABP and

Negative_regulation (decrease) of ABP
7) Confidence 0.05 Published 2008 Journal Anesthesiology Research and Practice Section Body Doc Link PMC3003954 Disease Relevance 0.23 Pain Relevance 0.14

General Comments

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