INT72250

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 2.87
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn1)
Anatomy Link Frequency
sensory neurons 1
dorsal 1
granule cells 1
Accn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 4 99.96 Very High Very High Very High
Spinal cord 47 98.96 Very High Very High Very High
Inflammation 18 97.12 Very High Very High Very High
Kinase C 12 95.00 High High
Pain 15 76.04 Quite High
dorsal root ganglion 2 75.00 Quite High
Mechanosensation 6 74.40 Quite High
Neuropathic pain 12 69.60 Quite High
qutenza 79 50.00 Quite Low
medulla 17 25.60 Quite Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 258 99.84 Very High Very High Very High
INFLAMMATION 18 97.12 Very High Very High Very High
Urological Neuroanatomy 2 93.56 High High
Acidosis 6 92.96 High High
Death 6 86.72 High High
Neurodegenerative Disease 6 81.76 Quite High
Targeted Disruption 6 79.40 Quite High
Pain 15 76.04 Quite High
Ganglion Cysts 6 75.00 Quite High
Neuropathic Pain 12 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDEG2, expressed in the brain and in sensory neurons, cannot form an active ionic channel as a standalone, but participates in an heterodimeric active ionic channel by interacting with another protein of its family.
MDEG2 Binding (interacting) of in sensory neurons
1) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.20 Pain Relevance 0.17
Association between the ACCN1 Gene and Multiple Sclerosis in Central East Sardinia

Multiple genome screens have been performed to identify regions in linkage or association with Multiple Sclerosis (MS, OMIM 126200), but little overlap has been found among them.

ACCN1 Binding (Association) of associated with demyelinating disease
2) Confidence 0.44 Published 2007 Journal PLoS ONE Section Title Doc Link PMC1868958 Disease Relevance 0.19 Pain Relevance 0
However, it can associate both with MDEG1 and another recently cloned H+-activated channel DRASIC to form heteropolymers which display different kinetics, pH dependences, and ion selectivities.
MDEG1 Binding (associate) of
3) Confidence 0.42 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9368048 Disease Relevance 0.14 Pain Relevance 0.20
The following points also indicate, albeit rather indirectly, plausibility of an involvement of ACCN1 in MS:
ACCN1 Binding (involvement) of associated with demyelinating disease
4) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 1.26 Pain Relevance 0.50
For example, MDEG2 interacts with the Amiloride-sensitive Cation Channel 3 (ACCN3) to form a channel where the ionic current is modulated by the Protein Kinase C, presumably the alpha isoform, [15] via shared interaction with the Protein Kinase C Alpha Binding Protein (PRKCABP), an adaptor protein encoded by the Protein Interacting with C Kinase 1 (PICK1, ENSG00000100151) gene.
MDEG2 Binding (interacts) of associated with kinase c
5) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.24 Pain Relevance 0.24
UTR region of ACCN1 gave significant marginal associations after adjusting for five-fold SNP testing.
ACCN1 Binding (associations) of
6) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.48 Pain Relevance 0
MDEG1, expressed in the postsynaptic membrane of granule cells and in the Purkinje cells of the cerebellum, can form an active ionic channel either as a standalone, or by binding other proteins of its family, and is activated by a low pH.
MDEG1 Binding (binding) of in granule cells
7) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.21 Pain Relevance 0.06
ASIC, acid-sensing ion channel; ANOVA, analysis of variance; AX, area X around the central canal of the spinal cord; HCl, hydrochloric acid; IG, intragastric; IGP, intragastric pressure; LI-LV, laminae I-V of the dorsal spinal horn; IMLN, intermediolateral nucleus; mRNA, messenger ribonucleic acid; NTS, nucleus tractus solitarii; Pa, Pascal; TRPV1, transient receptor potential ion channel of vanilloid type 1

Authors' contributions

acid-sensing ion channel Binding (around) of in dorsal associated with urological neuroanatomy, spinal cord and asic
8) Confidence 0.15 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0.15 Pain Relevance 0.10

General Comments

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