INT72252

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Context Info
Confidence 0.64
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 63
Total Number 69
Disease Relevance 20.47
Pain Relevance 29.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
Anatomy Link Frequency
neurons 7
sensory neurons 6
neuronal 6
oocytes 3
microglia 3
Kcnma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 110 100.00 Very High Very High Very High
potassium channel 52 100.00 Very High Very High Very High
TRP channel 49 100.00 Very High Very High Very High
Nav1.2 40 100.00 Very High Very High Very High
addiction 28 100.00 Very High Very High Very High
Glutamate receptor 18 100.00 Very High Very High Very High
Lamotrigine 6 100.00 Very High Very High Very High
carbamazepine 4 100.00 Very High Very High Very High
nociceptor 150 99.98 Very High Very High Very High
Nav1.1 16 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 106 99.48 Very High Very High Very High
Ganglion Cysts 792 99.40 Very High Very High Very High
Pain 234 99.28 Very High Very High Very High
Nociception 113 99.28 Very High Very High Very High
INFLAMMATION 314 99.00 Very High Very High Very High
Hyperalgesia 293 98.56 Very High Very High Very High
Hypersensitivity 20 98.48 Very High Very High Very High
Depression 52 98.20 Very High Very High Very High
Heart Rate Under Development 7 98.20 Very High Very High Very High
Reprotox - General 1 4 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At last, immunohistochemistry stainings were performed to observe expression of TRPV4/CGRP/MaxiK in mesenteric resistance arteries and sensory neurons/nerve fibers.
Gene_expression (expression) of MaxiK in nerve
1) Confidence 0.64 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry staining showed that TRPV4 colocalized with MaxiK channels in endothelium of mesenteric resistance arteries and with CGRP in sensory neurons/nerve fibers.
Gene_expression (channels) of MaxiK in endothelium
2) Confidence 0.55 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0 Pain Relevance 0
A conditionally immortalised cell line, HiB5, derived from embryonic hippocampal precursor cells expressed a voltage-gated Na+ channel with electrophysiological characteristics shifted to more negative voltages and a lower sensitivity to tetrodotoxin [concentration required for half-maximal inhibition (IC50) 0.9 microM] compared with endogenous neuronal Na+ channels.
Gene_expression (expressed) of channel in neuronal associated with tetrodotoxin
3) Confidence 0.52 Published 2001 Journal Pflugers Arch. Section Abstract Doc Link 11692262 Disease Relevance 0 Pain Relevance 0.13
Bilateral microinjection of the ionotropic glutamate receptor antagonist kynurenic acid (1 nmol) and the Na(+) channel blocker tetrodotoxin (10 pmol) into the region of the vlNTS consistently produced a similar prolongation of inspiratory duration and an apneustic pattern of breathing.
Gene_expression (microinjection) of channel associated with tetrodotoxin, antagonist and glutamate receptor
4) Confidence 0.30 Published 2000 Journal Brain Res. Section Abstract Doc Link 11032996 Disease Relevance 0.19 Pain Relevance 0.27
At last, immunohistochemistry stainings were performed to observe expression of TRPV4/CGRP/MaxiK in mesenteric resistance arteries and sensory neurons/nerve fibers.
Gene_expression (expression) of MaxiK in sensory neurons
5) Confidence 0.22 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0 Pain Relevance 0
(i) Transcripts for all three cloned SK channels (KCNN1, KCNN2, KCNN3) are expressed in microglia, but KCNN3 predominates and is the only channel up-regulated in LPS-activated microglia.
Gene_expression (expressed) of channel in microglia
6) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.27 Pain Relevance 0.13
(i) Transcripts for all three cloned SK channels (KCNN1, KCNN2, KCNN3) are expressed in microglia, but KCNN3 predominates and is the only channel up-regulated in LPS-activated microglia.
Gene_expression (predominates) of channel in microglia
7) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.27 Pain Relevance 0.10
The SK3 channel is under increasing scrutiny because of its expression patterns in neurons in the caudate putamen, hippocampus and dorsal motor nucleus, its role in action potential firing in dopaminergic neurons, and the possible links between several CNS disorders and SK3 mutations or changes in expression (see Discussion).
Gene_expression (is) of channel in hippocampus associated with action potential and hippocampus
8) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.11 Pain Relevance 0.29
The resulting impetus to develop SK3 inhibitors, activators and modulators as therapeutic tools makes it essential to understand the roles of this channel in other cells, both within the CNS and in peripheral tissues.
Gene_expression (roles) of channel
9) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0 Pain Relevance 0.19
The SK3 channel is under increasing scrutiny because of its expression patterns in neurons in the caudate putamen, hippocampus and dorsal motor nucleus, its role in action potential firing in dopaminergic neurons, and the possible links between several CNS disorders and SK3 mutations or changes in expression (see Discussion).
Gene_expression (The) of channel in hippocampus associated with action potential and hippocampus
10) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.11 Pain Relevance 0.29
The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro

Background

Gene_expression (expressed) of channel in microglia associated with drug induced neurotoxicity
11) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Title Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0
Moreover, the neuronal K(+) channel and heterologously expressed TASK-1 were similarly modulated by extracellular pH.
Gene_expression (expressed) of channel in neuronal
12) Confidence 0.07 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964940 Disease Relevance 0 Pain Relevance 0.24
Na(+) channel blockers, such as carbamazepine (CBZ) and lamotrigine (LTG), are efficacious in treating neuropathic pain; however, their therapeutic utility is compromised by central nervous system side effects.
Gene_expression (efficacious) of channel in central nervous system associated with neuropathic pain, lamotrigine, central nervous system and carbamazepine
13) Confidence 0.06 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16728593 Disease Relevance 0.36 Pain Relevance 0.77
The enhancement of GABAergic but not glycinergic transmission was largely depressed by Na(+) channel blocker tetrodotoxin or glutamate-receptor antagonists (6-cyano-7-nitroquinoxaline-2,3-dione and/or dl-2-amino-5-phosphonovaleric acid) and also in a Ca(2+)-free Krebs solution.
Gene_expression (depressed) of channel associated with tetrodotoxin, glutamate, antagonist and gabaergic
14) Confidence 0.05 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18216222 Disease Relevance 0.08 Pain Relevance 0.55
CONCLUSIONS: Our data suggest that I(Ca(TTX))-like current in PMI myocytes does not arise from classical Na(+) channels modified by oxidative stress or PKA phosphorylation and most probably represents a different Na(+) channel type re-expressed in some cells after remodelling.


Gene_expression (expressed) of channel in myocytes
15) Confidence 0.05 Published 2004 Journal Cardiovasc. Res. Section Body Doc Link 15306221 Disease Relevance 0 Pain Relevance 0
Inward current characteristics were also analysed in Xenopus laevis oocytes that heterologously expressed the human sodium channel alpha-subunit Nav1.5.
Gene_expression (expressed) of channel in oocytes
16) Confidence 0.05 Published 2004 Journal Cardiovasc. Res. Section Body Doc Link 15306221 Disease Relevance 0.09 Pain Relevance 0
We found that TRPV1 sensitization mediated by nerve growth factor, ATP, and IGF-I was accompanied by a higher channel expression in the neuronal plasma membrane, which was prevented by blockade of regulated exocytosis.
Gene_expression (expression) of channel in plasma associated with nerve growth factor
17) Confidence 0.04 Published 2009 Journal FASEB J. Section Abstract Doc Link 19584302 Disease Relevance 0.44 Pain Relevance 0.65
We have previously reported expression of a voltage-gated Na+ channel specifically in the highly metastatic Mat-LyLu rat prostate cancer cell line; blockage of the current with tetrodotoxin (TTX) significantly reduced the invasiveness of the cells in vitro, suggesting that the channel may have a functional role in metastasis.
Gene_expression (expression) of channel associated with tetrodotoxin, metastasis and reprotox - general 1
18) Confidence 0.04 Published 1998 Journal J. Cell. Physiol. Section Abstract Doc Link 9491780 Disease Relevance 0.26 Pain Relevance 0.19
In conclusion, the Na+ channel expressed in the highly metastatic Mat-LyLu cell line appeared to have electrophysiological and pharmacological properties of TTX-sensitive channels.
Gene_expression (expressed) of channel associated with tetrodotoxin
19) Confidence 0.04 Published 1998 Journal J. Cell. Physiol. Section Abstract Doc Link 9491780 Disease Relevance 0.13 Pain Relevance 0.33
Vanilloid receptor subtype 1 (VR1) is a non-selective cation channel detected on sensory neurons that is sensitive to capsaicin, the main pungent ingredient of hot chili pepper.
Gene_expression (detected) of channel in sensory neurons associated with vanilloid receptor subtype 1 and qutenza
20) Confidence 0.04 Published 2001 Journal Histochem. Cell Biol. Section Abstract Doc Link 11685550 Disease Relevance 0 Pain Relevance 0.68

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