INT72253

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Context Info
Confidence 0.63
First Reported 1997
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 2.64
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn1)
Anatomy Link Frequency
nerves 1
dorsal horn 1
granule cells 1
Accn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 20 100.00 Very High Very High Very High
b2 receptor 1 99.82 Very High Very High Very High
Dorsal horn 2 99.68 Very High Very High Very High
Inflammation 17 99.64 Very High Very High Very High
bradykinin 1 99.28 Very High Very High Very High
qutenza 7 97.92 Very High Very High Very High
Pain 20 95.20 Very High Very High Very High
antagonist 3 86.68 High High
Spinal cord 1 80.16 Quite High
Neuropathic pain 6 79.36 Quite High
Disease Link Frequency Relevance Heat
Acidosis 4 99.84 Very High Very High Very High
INFLAMMATION 14 99.64 Very High Very High Very High
Demyelinating Disease 129 99.00 Very High Very High Very High
Death 3 98.24 Very High Very High Very High
Neurodegenerative Disease 3 95.76 Very High Very High Very High
Nociception 1 95.28 Very High Very High Very High
Pain 12 95.20 Very High Very High Very High
Cv Unclassified Under Development 1 81.84 Quite High
Neuropathic Pain 6 79.36 Quite High
Ganglion Cysts 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDEG1, expressed in the postsynaptic membrane of granule cells and in the Purkinje cells of the cerebellum, can form an active ionic channel either as a standalone, or by binding other proteins of its family, and is activated by a low pH.
Positive_regulation (activated) of MDEG1 in granule cells
1) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.21 Pain Relevance 0.07
UTR segment of ACCN1 with p?
Positive_regulation (segment) of ACCN1
2) Confidence 0.46 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1868958 Disease Relevance 0.07 Pain Relevance 0
We would add that secondary inflammation in MS, as long as it is accompanied by acidosis, might activate the MDEG1 ion channel, and consequently lead to cell death in the context of a progressive, inflammation-mediated, neurodegenerative process.
Spec (might) Positive_regulation (activate) of MDEG1 associated with acidosis, inflammation, neurodegenerative disease, demyelinating disease and death
3) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 1.39 Pain Relevance 0.51
MDEG2 is activated neither by mutations that bring neurodegeneration once introduced in C. elegans degenerins nor by low pH.
Neg (neither) Positive_regulation (activated) of MDEG2
4) Confidence 0.41 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9368048 Disease Relevance 0.13 Pain Relevance 0.15
We conclude that H+ stimulates ASIC, evoking the reflex response, and that ASIC are likely to be frequently found on afferents containing VR1.
Positive_regulation (stimulates) of ASIC associated with asic
5) Confidence 0.30 Published 2004 Journal J. Appl. Physiol. Section Abstract Doc Link 15220301 Disease Relevance 0.08 Pain Relevance 0.54
Our laboratory's previous study has shown that H+ stimulates ASIC (but not VR1) on thin-fiber afferent nerves in evoking the reflex response.
Positive_regulation (stimulates) of ASIC in nerves associated with asic
6) Confidence 0.19 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16210435 Disease Relevance 0 Pain Relevance 0.34
The development of diffuse noxious inhibitory controls (DNIC) was studied in postnatal rats aged 12, 21 and 42-days-old, using immunoreactive localization of the c-fos protein products induced in the dorsal horn by noxious stimulation.
Positive_regulation (induced) of products in dorsal horn associated with dorsal horn
7) Confidence 0.10 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9857953 Disease Relevance 0 Pain Relevance 0.05
Acid-sensing ion channels (ASICs) are activated by a decrease in extracellular pH.
Positive_regulation (activated) of Acid-sensing associated with asic
8) Confidence 0.08 Published 2007 Journal Neuroscience Section Abstract Doc Link 17258862 Disease Relevance 0.33 Pain Relevance 0.30
Homomeric acid-sensing ion channel 1 (ASIC1) can be activated by extracellular H(+) in the physiological pH range and may, therefore, contribute to neurotransmission and peripheral pain perception.
Positive_regulation (activated) of Homomeric acid-sensing ion channel 1 associated with pain
9) Confidence 0.07 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12198124 Disease Relevance 0.10 Pain Relevance 0.10
The progresses of molecular biology have once again enriched this peripheral inflammatory mix, which composition becomes more and more complicated: ATP and P2X3 purinergic receptor, bradykinin and B2 bradykinin receptor, H+ and ASIC proton receptor, vanilloïd receptor activated by heat, inflammation and increase in synthesis of sodic channels resistant to the tetradotoxine (TTXr)....
Positive_regulation (ctivated ) of ASIC proton receptor associated with inflammation, b2 receptor, bradykinin and asic
10) Confidence 0.01 Published 2003 Journal Nephrologie Section Abstract Doc Link 14650754 Disease Relevance 0.34 Pain Relevance 0.69

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