INT72254

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Context Info
Confidence 0.71
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 3.24
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn1)
Anatomy Link Frequency
sensory neurons 4
brain 2
granule cells 1
Accn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 40 97.24 Very High Very High Very High
ASIC 28 91.56 High High
dorsal root ganglion 24 86.72 High High
Mechanosensation 9 86.12 High High
Kinase C 15 83.12 Quite High
ischemia 6 77.68 Quite High
Inflammation 16 76.12 Quite High
Root ganglion neuron 2 75.00 Quite High
Action potential 2 74.96 Quite High
Serotonin 1 73.60 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 215 99.70 Very High Very High Very High
Pain 35 97.24 Very High Very High Very High
Myocardial Infarction 1 91.12 High High
Ganglion Cysts 29 85.76 High High
Cancer 1 78.12 Quite High
Cv Unclassified Under Development 5 77.68 Quite High
Hematoma 1 76.56 Quite High
INFLAMMATION 16 76.12 Quite High
Nociception 15 63.64 Quite High
Inflammatory Pain 1 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDEG2, expressed in the brain and in sensory neurons, cannot form an active ionic channel as a standalone, but participates in an heterodimeric active ionic channel by interacting with another protein of its family.
Gene_expression (expressed) of MDEG2 in sensory neurons
1) Confidence 0.71 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.14 Pain Relevance 0.07
MDEG1, expressed in the postsynaptic membrane of granule cells and in the Purkinje cells of the cerebellum, can form an active ionic channel either as a standalone, or by binding other proteins of its family, and is activated by a low pH.
Gene_expression (expressed) of MDEG1 in granule cells
2) Confidence 0.71 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.21 Pain Relevance 0.03
MDEG1 is a cation channel expressed in brain that belongs to the degenerin/epithelial Na+ channel superfamily.
Gene_expression (expressed) of MDEG1 in brain
3) Confidence 0.68 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9368048 Disease Relevance 0.07 Pain Relevance 0.10
untranslated (UTR) region of ACCN1, and investigated the MS association of Single Nucleotide Polymorphisms (SNPs) identified in that region.
Gene_expression (region) of ACCN1
4) Confidence 0.61 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1868958 Disease Relevance 0.13 Pain Relevance 0
While it cannot be excluded that MYO1D, TMEM98 or SPACA3 are involved in MS pathogenesis, ACCN1 immediately appeared to be the only strong MS susceptibility candidate gene in the region explored (see the Discussion section for further bio-epidemiological evidence pointing at ACCN1).
Gene_expression (appeared) of ACCN1 associated with demyelinating disease
5) Confidence 0.61 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.20 Pain Relevance 0
UTR segment of ACCN1, where SNPs were identified and tested for MS association.
Gene_expression (segment) of ACCN1 associated with demyelinating disease
6) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.45 Pain Relevance 0
This new membrane protein, which has been called MDEG2, is expressed in both brain and sensory neurons.
Gene_expression (expressed) of MDEG2 in sensory neurons
7) Confidence 0.52 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9368048 Disease Relevance 0.07 Pain Relevance 0.12
Here, we show that ASIC3 (acid-sensing ion channel #3) has the appropriate expression pattern and physical properties to be the detector of this lactic acid.
Gene_expression (expression) of acid-sensing ion channel
8) Confidence 0.43 Published 2005 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 16258623 Disease Relevance 0.58 Pain Relevance 0.42
The ASIC2-like responses and the TRPV1 responses tended to decrease in amplitude with repetitive application of pH 5.5 even at 22 degrees C.
Gene_expression (responses) of ASIC2-like
9) Confidence 0.19 Published 2010 Journal Brain Res. Section Abstract Doc Link 20206612 Disease Relevance 0.13 Pain Relevance 0.43
This new membrane protein, which has been called MDEG2, is expressed in both brain and sensory neurons.
Gene_expression (expressed) of MDEG2 in brain
10) Confidence 0.18 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9368048 Disease Relevance 0.07 Pain Relevance 0.12
MDEG2 is selectively expressed in DRGs, where it assembles with DRASIC to radically change its biophysical properties, making it similar to the native H(+)-gated channel, which is presently the best candidate for pain perception.
Gene_expression (expressed) of MDEG2 associated with pain
11) Confidence 0.13 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10414282 Disease Relevance 0.68 Pain Relevance 0.57
ASIC3, an acid-sensing ion channel subunit expressed essentially in sensory neurons, has been proposed to be involved in pain.
Gene_expression (expressed) of acid-sensing ion channel in sensory neurons associated with pain
12) Confidence 0.12 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14976185 Disease Relevance 0.26 Pain Relevance 0.40
ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons

Background

Gene_expression (expressed) of acid-sensing in sensory neurons
13) Confidence 0.01 Published 2005 Journal Mol Pain Section Title Doc Link PMC1308857 Disease Relevance 0.23 Pain Relevance 0.20

General Comments

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