INT72255

Context Info Confidence 0.02 First Reported 1997 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.20 Pain Relevance 0.99

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)

Kcnma1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat qutenza 3 97.80 tetrodotoxin 4 94.88 local anesthetic 2 93.28 ASIC 2 79.24 dorsal root ganglion 3 75.00 sodium channel 1 75.00 Pain 1 61.28

Disease Link Frequency Relevance Heat Ganglion Cysts 3 75.00 Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Site-directed mutagenesis has identified clusters of common residues at D1-S6, D3-S6, and D4-S6 segments within the alpha-subunit Na(+) channel that are critical for binding of these two types of ligands.

channel Binding (binding) of

1) Confidence 0.02 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11306693 Disease Relevance 0 Pain Relevance 0.17

The PbTx-3 molecule is proposed to have multiple active centers (A-ring lactone, C-42 of R side chain) interacting with the Na+ channel binding site.

channel Binding (interacting) of

2) Confidence 0.01 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454792 Disease Relevance 0 Pain Relevance 0.39

However, it can associate both with MDEG1 and another recently cloned H+-activated channel DRASIC to form heteropolymers which display different kinetics, pH dependences, and ion selectivities.

channel Binding (associate) of

3) Confidence 0.00 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9368048 Disease Relevance 0.14 Pain Relevance 0.21

Although its channel activity is reportedly modulated through protein-protein interactions, to date very few VR1 interacting proteins have been identified.

channel Binding (interactions) of

4) Confidence 0.00 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883036 Disease Relevance 0.06 Pain Relevance 0.23

General Comments

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