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Context Info
Confidence 0.02
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.20
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
Kcnma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 3 97.80 Very High Very High Very High
tetrodotoxin 4 94.88 High High
local anesthetic 2 93.28 High High
ASIC 2 79.24 Quite High
dorsal root ganglion 3 75.00 Quite High
sodium channel 1 75.00 Quite High
Pain 1 61.28 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 75.00 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Site-directed mutagenesis has identified clusters of common residues at D1-S6, D3-S6, and D4-S6 segments within the alpha-subunit Na(+) channel that are critical for binding of these two types of ligands.
channel Binding (binding) of
1) Confidence 0.02 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11306693 Disease Relevance 0 Pain Relevance 0.17
The PbTx-3 molecule is proposed to have multiple active centers (A-ring lactone, C-42 of R side chain) interacting with the Na+ channel binding site.
channel Binding (interacting) of
2) Confidence 0.01 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454792 Disease Relevance 0 Pain Relevance 0.39
However, it can associate both with MDEG1 and another recently cloned H+-activated channel DRASIC to form heteropolymers which display different kinetics, pH dependences, and ion selectivities.
channel Binding (associate) of
3) Confidence 0.00 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9368048 Disease Relevance 0.14 Pain Relevance 0.21
Although its channel activity is reportedly modulated through protein-protein interactions, to date very few VR1 interacting proteins have been identified.
channel Binding (interactions) of
4) Confidence 0.00 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883036 Disease Relevance 0.06 Pain Relevance 0.23

General Comments

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