INT72256

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.01
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
muscle 1
Accn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 39 100.00 Very High Very High Very High
Hyperalgesia 1 99.76 Very High Very High Very High
Angina 4 99.36 Very High Very High Very High
Pain 24 98.32 Very High Very High Very High
Spinal nerve ligature 11 97.44 Very High Very High Very High
trigeminal ganglion 7 96.64 Very High Very High Very High
dorsal root ganglion 24 88.16 High High
ischemia 4 75.00 Quite High
Spontaneous pain 1 67.40 Quite High
withdrawal 1 60.24 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 99.76 Very High Very High Very High
Cv General 3 Under Development 4 99.36 Very High Very High Very High
Pain 18 98.32 Very High Very High Very High
Ganglion Cysts 34 96.64 Very High Very High Very High
Nociception 16 75.00 Quite High
Coronary Artery Disease 2 75.00 Quite High
Cv Unclassified Under Development 2 61.08 Quite High
Neuropathic Pain 2 53.64 Quite High
Lactic Acidosis 2 46.32 Quite Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that ASIC3 is associated with hyperalgesia in response to a chemical stimulus in the L5 SNL rat model.
ASIC3 Binding (associated) of associated with hyperalgesia and spinal nerve ligature
1) Confidence 0.47 Published 2008 Journal Brain Res. Section Abstract Doc Link 18534561 Disease Relevance 0.73 Pain Relevance 1.24
The arrows point to three ASIC3-positive muscle afferents that did not stain for CGRP.
ASIC3-positive Binding (point) of in muscle
2) Confidence 0.33 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.05 Pain Relevance 0
We suggest that this sustained mode is the most relevant form of ASIC3 gating for triggering angina and other ischemic pain.
ASIC3 Binding (gating) of associated with pain and angina
3) Confidence 0.33 Published 2006 Journal Circ. Res. Section Abstract Doc Link 16873722 Disease Relevance 0.39 Pain Relevance 0.46
However, it associated with ASIC-beta to form heteromers, which display lower affinity for protons than ASIC-beta alone.
ASIC-beta Binding (associated) of associated with asic
4) Confidence 0.06 Published 2001 Journal Neuroreport Section Abstract Doc Link 11588592 Disease Relevance 0.35 Pain Relevance 0.65
However, it associated with ASIC-beta to form heteromers, which display lower affinity for protons than ASIC-beta alone.
ASIC-beta Binding (affinity) of associated with asic
5) Confidence 0.04 Published 2001 Journal Neuroreport Section Abstract Doc Link 11588592 Disease Relevance 0.34 Pain Relevance 0.64
However, it can associate both with MDEG1 and another recently cloned H+-activated channel DRASIC to form heteropolymers which display different kinetics, pH dependences, and ion selectivities.
DRASIC Binding (associate) of
6) Confidence 0.03 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9368048 Disease Relevance 0.14 Pain Relevance 0.21

General Comments

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