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Context Info
Confidence 0.32
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA3) cytoplasm (CA3)
Anatomy Link Frequency
neurons 1
cortex 1
A-D 1
CA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 1 98.94 Very High Very High Very High
tetrodotoxin 2 98.68 Very High Very High Very High
sodium channel 1 98.10 Very High Very High Very High
Action potential 12 96.88 Very High Very High Very High
Sciatic nerve 4 96.72 Very High Very High Very High
Hippocampus 10 73.40 Quite High
repetitive firing 2 69.00 Quite High
Pyramidal cell 4 52.08 Quite High
potassium channel 83 50.00 Quite Low
hyperexcitability 6 43.32 Quite Low
Disease Link Frequency Relevance Heat
Death 4 97.30 Very High Very High Very High
Convulsion 7 93.68 High High
Syndrome 44 62.68 Quite High
Limbic Encephalitis 27 61.96 Quite High
Glioma 6 50.00 Quite Low
Amnesia 4 31.44 Quite Low
Confusion 4 30.72 Quite Low
Targeted Disruption 2 30.40 Quite Low
Hyponatremia 3 17.92 Low Low
Epilepsy 33 15.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although respective blockade of inhibitory and excitatory neurotransmission by picrotoxin and CNQX did not significantly induce cell death in all hippocampal area, sodium channel blocking drugs (tetrodotoxin or lidocaine) caused specific and severe damage and affected the formation of functional synapse in CA1 and the entorhinal cortex but not in CA3.
CA3 Binding (formation) of in cortex associated with tetrodotoxin, sodium channel, lidocaine and death
1) Confidence 0.32 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9370066 Disease Relevance 0.10 Pain Relevance 0.37
Control sera show no specific binding in CA3 or cerebellum (A–D).
CA3 Neg (no) Binding (binding) of in A-D
2) Confidence 0.06 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.35 Pain Relevance 0.11
In this study, we present a single-compartment computational framework where the goal is to reveal the contribution of important ionic components and their interaction to bursting in CA3 neurons.
CA3 Binding (interaction) of in neurons
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2323611 Disease Relevance 0.09 Pain Relevance 0.06

General Comments

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