INT72316

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Context Info
Confidence 0.07
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.19
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
striatum 1
Amp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Delta opioid receptors 1 99.80 Very High Very High Very High
Enkephalin 1 94.28 High High
alcohol 24 92.04 High High
opioid receptor 4 88.72 High High
agonist 31 68.04 Quite High
Opioid 1 46.00 Quite Low
Eae 1 41.96 Quite Low
tolerance 13 23.08 Low Low
Kinase C 1 10.56 Low Low
ischemia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 21 96.76 Very High Very High Very High
Impaired Glucose Tolerance 21 92.56 High High
Hyperinsulinism 5 91.60 High High
Alcoholic Cardiomyopathy 8 90.36 High High
Body Weight 3 88.36 High High
Diabetes Mellitus 12 84.52 Quite High
Stress 19 79.92 Quite High
Disease 8 73.84 Quite High
Insulin Resistance 15 64.48 Quite High
Toxicity 14 58.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of in vivo ethanol consumption on cyclic AMP and delta-opioid receptors in mouse striatum.
Regulation (effect) of AMP in striatum associated with delta opioid receptors
1) Confidence 0.07 Published 1997 Journal Brain Res. Section Title Doc Link 9372204 Disease Relevance 0 Pain Relevance 0.23
While neither acute ethanol exposure nor ADH overtly affected cardiac ATP levels, acute ethanol treatment significantly elevated the AMP levels and AMP/ATP ratio in both mouse groups with a more pronounced increase in AMP/ATP ratio in the ADH mice.
Regulation (ratio) of AMP
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.09 Pain Relevance 0.09
Furthermore, data from our present study revealed change in the AMP-to-ATP ratio and hyperactivated AMPK signaling cascade following acute ethanol challenge, which is associated with ethanol-elicited cardiac dysfunction, intracellular Ca2+ mishandling, glucose intolerance and hyperinsulinemia.
Regulation (change) of AMP associated with hyperinsulinism and impaired glucose tolerance
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.45 Pain Relevance 0
AMPK is a serine/threonine protein kinase which physiologically responds to the change in the cellular AMP to ATP ratio.
Regulation (change) of AMP
4) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.35 Pain Relevance 0.07
Due to its strong association to energy status, deregulation of the PPARs-circadian clock system is believed to contribute, at least in part, to the development of metabolic syndrome.
Regulation (deregulation) of PPARs-circadian associated with metabolic syndrome
5) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.30 Pain Relevance 0

General Comments

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