INT72319

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Context Info
Confidence 0.10
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0.10
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Adarb1, Fos) nucleus (Adarb1, Fos) nucleoplasm (Adarb1)
aging (Fos) mRNA processing (Adarb1) RNA binding (Adarb1)
Anatomy Link Frequency
brain 2
forebrain 2
locus coeruleus 2
Adarb1 (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 9 100.00 Very High Very High Very High
qutenza 8 100.00 Very High Very High Very High
parabrachial 4 100.00 Very High Very High Very High
mu opioid receptor 2 100.00 Very High Very High Very High
Cholecystokinin 1 99.98 Very High Very High Very High
agonist 1 88.04 High High
Enkephalin 1 86.60 High High
antagonist 5 82.12 Quite High
Nucleus accumbens 1 60.76 Quite High
Intracerebroventricular 1 57.68 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 2 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gastric distension-induced release of 5-HT stimulates c-fos expression in specific brain nuclei via 5-HT3 receptors in conscious rats.
receptors Positive_regulation (stimulates) of Gene_expression (expression) of c-fos in brain associated with qutenza
1) Confidence 0.10 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 14684379 Disease Relevance 0 Pain Relevance 0.22
Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicin-sensitive vagal afferents and CCK-A receptors in the rat.
receptors Positive_regulation (activates) of Gene_expression (expression) of c-fos in locus coeruleus associated with qutenza, locus ceruleus and cholecystokinin
2) Confidence 0.05 Published 1997 Journal Brain Res. Section Title Doc Link 9372230 Disease Relevance 0 Pain Relevance 0.72
Activating mu-opioid receptors in the lateral parabrachial nucleus increases c-Fos expression in forebrain areas associated with caloric regulation, reward and cognition.
receptors Positive_regulation (increases) of Gene_expression (expression) of c-Fos in forebrain associated with cognitive disorder, mu opioid receptor and parabrachial
3) Confidence 0.03 Published 2009 Journal Neuroscience Section Title Doc Link 19422884 Disease Relevance 0.10 Pain Relevance 0.50

General Comments

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