INT7232

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Context Info
Confidence 0.45
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.63
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
CPA 2
ovary 2
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 6 100.00 Very High Very High Very High
Opioid 4 99.80 Very High Very High Very High
narcan 27 99.72 Very High Very High Very High
Dismenorea 5 94.24 High High
Migraine 9 93.60 High High
opioid receptor 1 88.36 High High
nud 1 84.64 Quite High
Pain 2 81.52 Quite High
analgesia 1 75.88 Quite High
Central nervous system 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Hirsutism 31 98.04 Very High Very High Very High
Uterine Hemorrhage 1 95.76 Very High Very High Very High
Reprotox - General 1 8 94.24 High High
Hyperkalemia 2 94.08 High High
Headache 8 93.60 High High
Anuria 1 92.48 High High
Renal Insufficiency 2 92.16 High High
Gastritis 2 89.32 High High
Migraine Without Aura 4 88.96 High High
Rheumatoid Arthritis 6 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest that ovarian secretions and the suckling stimulus contribute to endogenous opioid inhibition of LH during the postpartum interval.
Regulation (contribute) of Negative_regulation (inhibition) of LH associated with endogenous opioid
1) Confidence 0.45 Published 1989 Journal J. Anim. Sci. Section Abstract Doc Link 2670869 Disease Relevance 0 Pain Relevance 0.29
With all methods of administration there was an initial rise in LH, usually followed by a rise in testosterone, after which the SC infusion and the depot were both effective in reducing serum LH to basal levels and testosterone into the castrate range within 1 month.
Regulation (effective) of Negative_regulation (reducing) of LH
2) Confidence 0.39 Published 1986 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 2944668 Disease Relevance 0.22 Pain Relevance 0.08
LH responsiveness to LHRH was similar in the mid and late luteal phases and did not change between groups.
Neg (not) Regulation (change) of Negative_regulation (responsiveness) of LH
3) Confidence 0.30 Published 1988 Journal J Reprod Med Section Abstract Doc Link 3050071 Disease Relevance 1.16 Pain Relevance 1.39
The opioid-mediated suppression of LH and FSH release does not seem to be affected by suckling.
Regulation (affected) of Negative_regulation (suppression) of LH associated with opioid
4) Confidence 0.20 Published 1993 Journal J. Reprod. Fertil. Section Abstract Doc Link 8410818 Disease Relevance 0 Pain Relevance 0.50
The role of norepinephrine (NE) in the progesterone (P)-dependent endogenous opioid peptide (EOP) suppression of LH and prolactin (PRL) secretion in the pig was studied.
Regulation (role) of Negative_regulation (suppression) of LH associated with endogenous opioid
5) Confidence 0.14 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8353185 Disease Relevance 0 Pain Relevance 0.17
In both phase I and II studies arzoxifene showed similar endocrine effects of decreasing FSH and LH levels with increasing SHBG levels as had been reported with tamoxifen (L√łnning et al. 1995; Kostoglou-Athanassiou et al. 1997).
Regulation (effects) of Negative_regulation (decreasing) of LH
6) Confidence 0.08 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.55 Pain Relevance 0.08
It was concluded that the increases in blood-borne beta-endorphin did not cause the decrease in LH release.
Neg (not) Regulation (cause) of Negative_regulation (decrease) of LH in blood
7) Confidence 0.07 Published 1987 Journal J. Reprod. Fertil. Suppl. Section Abstract Doc Link 2957499 Disease Relevance 0 Pain Relevance 0.25
Endogenous opioid peptide (EOP) inhibition of pulsatile LH and prolactin (PRL) secretion is dependent on reproductive status and development of this EOP system is a brain maturational process independent of the ovary.
Regulation (dependent) of Negative_regulation (inhibition) of LH in ovary associated with endogenous opioid
8) Confidence 0.05 Published 1992 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 1343978 Disease Relevance 0 Pain Relevance 0.40
It produces a decrease in circulating Tst and androstenedione levels through a reduction in circulating LH and has been used as an effective treatment for hirsutism.[21] CPA is available in combination with ethinyl estradiol (EE) (2 mg CPA and 35 ?
Regulation (circulating) of Negative_regulation (reduction) of LH in CPA associated with hirsutism
9) Confidence 0.02 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2856356 Disease Relevance 1.71 Pain Relevance 0.11

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