INT72329

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 12.52
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
ARC 4
dentate gyrus 1
granule cells 1
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 7 98.96 Very High Very High Very High
long-term potentiation 127 98.24 Very High Very High Very High
Dynorphin 4 92.96 High High
Opioid 6 88.64 High High
depression 84 88.00 High High
Neuropeptide 6 86.56 High High
Glutamate receptor 16 84.96 Quite High
antagonist 35 84.56 Quite High
Enkephalin 12 78.56 Quite High
agonist 13 74.04 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 1001 100.00 Very High Very High Very High
Diabetes Mellitus 10 99.90 Very High Very High Very High
Cognitive Disorder 161 99.28 Very High Very High Very High
Obesity 30 98.68 Very High Very High Very High
Body Weight 24 95.84 Very High Very High Very High
Targeted Disruption 51 91.68 High High
Weight Gain 1 89.36 High High
Hyperphagia 5 88.40 High High
Depression 91 88.00 High High
Apoptosis 2 52.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
minutes to reach maximum arc/zif-268 mRNA levels with reference to the moment when criterion was reached.
Transcription (levels) of arc associated with aids-related complex
1) Confidence 0.67 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.19 Pain Relevance 0
Surprisingly, no significant change in Arc mRNA levels could be observed
Transcription (levels) of Arc associated with aids-related complex
2) Confidence 0.66 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.69 Pain Relevance 0
learning about objects and their configuration on Arc mRNA expression using in situ hybridization (Figure 3).
Transcription (expression) of Arc associated with aids-related complex
3) Confidence 0.66 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.88 Pain Relevance 0
Arc mRNA expression in granule cells of
Transcription (expression) of Arc in granule cells associated with aids-related complex
4) Confidence 0.66 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.48 Pain Relevance 0
Western blot was used to assess the expression levels of Arc protein in
Transcription (levels) of Arc protein associated with aids-related complex
5) Confidence 0.63 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.63 Pain Relevance 0
Western blot was used to assess the expression levels of Arc protein in
Transcription (assess) of Arc protein associated with aids-related complex
6) Confidence 0.63 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.68 Pain Relevance 0
Upon induction, Arc mRNA is rapidly
Transcription (mRNA) of Arc associated with aids-related complex
7) Confidence 0.63 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.54 Pain Relevance 0.19
Arc mRNA was only
Transcription (was) of Arc associated with aids-related complex
8) Confidence 0.63 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.86 Pain Relevance 0
This

issue was first addressed by semiquantitative RT-PCR analysis of Arc mRNA

Transcription (analysis) of Arc associated with aids-related complex
9) Confidence 0.63 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.68 Pain Relevance 0
minutes after reaching state criterion was the induction kinetics of arc and zif-268 mRNA, characterized by a bell-shaped profile that peaks 30?
Transcription (kinetics) of arc associated with aids-related complex
10) Confidence 0.58 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.19 Pain Relevance 0
It is always possible that changes in mRNA levels do not cause equivalent changes in protein levels, although the previous studies show a tight correlation between mRNA and protein levels for zif-268 (Wisden et al., 1990) and arc (Lyford et al., 1995; Ramirez-Amaya et al., 2005).
Transcription (levels) of arc associated with aids-related complex
11) Confidence 0.58 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.24 Pain Relevance 0
Similarly, the increase in Arc mRNA expression could be linked to cAMP, glutamate and BDNF [70].
Transcription (expression) of Arc associated with glutamate and aids-related complex
12) Confidence 0.53 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.42 Pain Relevance 0.50
and sparse increase in Arc mRNA expression in both blades of the DG.
Transcription (expression) of Arc associated with aids-related complex
13) Confidence 0.49 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.59 Pain Relevance 0
exhibited a sustained increase in Arc mRNA expression up to one-hour
Transcription (expression) of Arc associated with aids-related complex
14) Confidence 0.49 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.58 Pain Relevance 0
RT-PCR analysis from dentate gyrus tissue collected shortly after training did not reveal learning-specific changes in Arc mRNA expression.
Transcription (expression) of Arc in dentate gyrus associated with aids-related complex
15) Confidence 0.49 Published 2008 Journal Neural Plasticity Section Abstract Doc Link PMC2631155 Disease Relevance 0.28 Pain Relevance 0
This motivational state was associated with increased transcription of the activity-regulated genes homer1a, arc, zif268, ngfi-b and c-fos in corticolimbic, thalamic and hypothalamic areas and of proenkephalin within striatal regions.
Transcription (transcription) of arc associated with aids-related complex
16) Confidence 0.42 Published 2007 Journal BMC Biol Section Abstract Doc Link PMC1868707 Disease Relevance 0.10 Pain Relevance 0.06
Prodynorphin (proDyn) mRNA increased in diabetes and normalized in the pituitary after insulin but not in the Arc.
Transcription (normalized) of Arc in Arc associated with aids-related complex and diabetes mellitus
17) Confidence 0.37 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10233022 Disease Relevance 1.37 Pain Relevance 0.16
In both saline and NTX-treated lactating subjects, ARC mRNA levels of proDYN, POMC and proENK were significantly decreased compared with the saline or NTX-treated post-lactating subjects (P < 0.01).
Transcription (levels) of ARC in ARC associated with aids-related complex
18) Confidence 0.31 Published 1997 Journal Brain Res. Section Abstract Doc Link 9374199 Disease Relevance 0.45 Pain Relevance 0.34
mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Transcription (levels) of ARC associated with aids-related complex
19) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.79 Pain Relevance 0
In contrast, knocking down Arc Fto expression by 40% increases food intake by 16%. mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Transcription (levels) of ARC in ARC associated with aids-related complex
20) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.65 Pain Relevance 0

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