INT72330

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.35
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
ARC 1
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 210 98.08 Very High Very High Very High
Nucleus accumbens 70 97.92 Very High Very High Very High
Neuropeptide 6 90.16 High High
Opioid 3 89.44 High High
Enkephalin 1 78.56 Quite High
Dynorphin 1 76.28 Quite High
antagonist 5 52.96 Quite High
Nicotine 2 41.36 Quite Low
alcohol 2 40.80 Quite Low
Morphine 4 40.44 Quite Low
Disease Link Frequency Relevance Heat
Aids-related Complex 208 100.00 Very High Very High Very High
Hyperphagia 3 98.06 Very High Very High Very High
Body Weight 30 95.84 Very High Very High Very High
Osteogenic Sarcomas 4 89.00 High High
Obesity 27 78.84 Quite High
Weight Gain 4 74.28 Quite High
Body Weight Changes 1 65.40 Quite High
Cognitive Disorder 14 51.52 Quite High
Appetite Loss 7 16.64 Low Low
Apoptosis 3 12.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
exploration of the environment induced a rapid and sustained decrease in Arc
Negative_regulation (decrease) of Arc associated with aids-related complex
1) Confidence 0.40 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.70 Pain Relevance 0
In both saline and NTX-treated lactating subjects, ARC mRNA levels of proDYN, POMC and proENK were significantly decreased compared with the saline or NTX-treated post-lactating subjects (P < 0.01).
Negative_regulation (decreased) of ARC in ARC associated with aids-related complex
2) Confidence 0.34 Published 1997 Journal Brain Res. Section Abstract Doc Link 9374199 Disease Relevance 0.46 Pain Relevance 0.35
Persistent decreases (Category 2 or 3) in Arc, Fos, and Nr4a1 were observed in both the mPFC and NAc.
Negative_regulation (decreases) of Arc associated with nucleus accumbens and aids-related complex
3) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.27 Pain Relevance 0.22
Persistent reductions in levels of CD47 and Arc, and inductions in levels of Drd5 and NPY suggest altered synaptic plasticity process involved in memory formation and removal of old memory traces, respectively [50,57,58].
Negative_regulation (reductions) of Arc associated with aids-related complex
4) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.17 Pain Relevance 0.13
Our findings demonstrate that reduction in Fto expression selectively in the ARC results in increased food intake, a finding consistent with the hyperphagia seen in mice lacking Fto and congruent with the fact that fasting (a strong stimulus to eating) reduces Fto mRNA levels in the ARC [16].
Negative_regulation (reduces) of ARC associated with hyperphagia and aids-related complex
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.81 Pain Relevance 0
To modulate Fto expression levels in the ARC and PVN, we generated four AAV 2/7vectors: i.)
Negative_regulation (levels) of ARC associated with aids-related complex
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.43 Pain Relevance 0
Rats with diminished ARC Sirt1 protein consumed less food (Figure 1B, left), and gained less weight compared to the control group (Figure 1B, right).


Negative_regulation (diminished) of ARC associated with aids-related complex
7) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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